47 research outputs found
Relaxation channels of two-vibron bound states in \alpha-helix proteins
Relaxation channels for two-vibron bound states in an anharmonic alpha-helix
protein are studied. It is pointed out that the relaxation originates in the
interaction between the dressed anharmonic vibrons and the remaining phonons.
This interaction is responsible for the occurrence of transitions between
two-vibron eigenstates mediated by both phonon absorption and phonon emission.
At biological temperature, it is shown that the relaxation rate does not
significantly depends on the nature of the two-vibron state involved in the
process. Therefore, the lifetime for both bound and free states is of the same
order of magnitude and ranges between 0.1 and 1.0 ps for realistic parameters.
By contrast, the relaxation channels strongly depend on the nature of the
two-vibron states which is a consequence of the breather-like behavior of the
two-vibron bound states.Comment: octobre 2003 - soumis Phys. Rev.
The longitudinal cross section of vector meson electroproduction
We analyze electroproduction of light vector mesons (V=rho, phi and omega) at
small Bjorken-x in the handbag approach in which the process factorizes into
general parton distributions and partonic subprocesses. The latter are
calculated in the modified perturbative approach where the transverse momenta
of the quark and antiquark forming the vector meson are retained and Sudakov
suppressions are taken into account. Modeling the generalized parton
distributions through double distributions and using simple Gaussian
wavefunctions for the vector mesons, we compute the longitudinal cross sections
at large photon virtualities. The results are in fair agreement with the
findings of recent experiments performed at HERA and HERMES.Comment: 27 pages, 20 figures, using LATEX with graphic
Evidence for SU(3) symmetry breaking from hyperon production
We examine the SU(3) symmetry breaking in hyperon semileptonic decays (HSD)
by considering two typical sets of quark contributions to the spin content of
the octet baryons: Set-1 with SU(3) flavor symmetry and Set-2 with SU(3) flavor
symmetry breaking in HSD. The quark distributions of the octet baryons are
calculated with a successful statistical model. Using an approximate relation
between the quark fragmentation functions and the quark distributions, we
predict polarizations of the octet baryons produced in annihilation
and semi-inclusive deeply lepton-nucleon scattering in order to reveal the
SU(3) symmetry breaking effect on the spin structure of the octet baryons. We
find that the SU(3) symmetry breaking significantly affects the hyperon
polarization. The available experimental data on the polarization
seem to favor the theoretical predictions with SU(3) symmetry breaking. We
conclude that there is a possibility to get a collateral evidence for SU(3)
symmetry breaking from hyperon production. The theoretical errors for our
predictions are discussed.Comment: 3 tables, 14 figure
Does the proteasome inhibitor bortezomib sensitize to DNA-damaging therapy in gastroenteropancreatic neuroendocrine neoplasms? – A preclinical assessment in vitro and in vivo
Background: Well-differentiated gastroenteropancreatic neuroendocrine neoplasms are rare tumors with a slow proliferation. They are virtually resistant to many DNA-damaging therapeutic approaches, such as chemo- and external beam therapy, which might be overcome by DNA damage inhibition induced by proteasome inhibitors suc
Review of K.H. Pridie (1959) on "A method of resurfacing osteoarthritic knee joints".
This classic discusses the original publication "A method of resurfacing osteoarthritic knee joints" by Dr K.H. Pridie (1959), where this pioneer surgeon described a newly developed method for the treatment of osteoarthritic joint surfaces of the knee, which he named subchondral drilling. This short and concise 11-line publication appeared in the Proceedings of the Congress of the British Orthopaedic Association. It has generated 464 citations since 1959, becoming part of the hundred most-cited publications in knee research. Pridie introduced in clinical experimentation the entity of Marrow Stimulation Techniques to liberate mesenchymal stem cells from cancellous bone. He was aware that the results induced, in terms of quality of the regrown tissue, was limited and "only" fibrocartilage. His idea might have been raised from the work of numerous animal researchers who confirmed repeatedly since 1905 that cartilage needed an osseous perforation to heal. Although the past 60 years brought modifications from the technique described in the original article, the concept of marrow stimulation introduced by Pridie remains the most frequently used in cartilage repair surgery today