381 research outputs found

    Supporting security-oriented, collaborative nanoCMOS electronics research

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    Grid technologies support collaborative e-Research typified by multiple institutions and resources seamlessly shared to tackle common research problems. The rules for collaboration and resource sharing are commonly achieved through establishment and management of virtual organizations (VOs) where policies on access and usage of resources by collaborators are defined and enforced by sites involved in the collaboration. The expression and enforcement of these rules is made through access control systems where roles/privileges are defined and associated with individuals as digitally signed attribute certificates which collaborating sites then use to authorize access to resources. Key to this approach is that the roles are assigned to the right individuals in the VO; the attribute certificates are only presented to the appropriate resources in the VO; it is transparent to the end user researchers, and finally that it is manageable for resource providers and administrators in the collaboration. In this paper, we present a security model and implementation improving the overall usability and security of resources used in Grid-based e-Research collaborations through exploitation of the Internet2 Shibboleth technology. This is explored in the context of a major new security focused project at the National e-Science Centre (NeSC) at the University of Glasgow in the nanoCMOS electronics domain

    Federated authentication and authorisation for e-science

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    The Grid and Web service community are defining a range of standards for a complete solution for security. The National e-Science Centre (NeSC) at the University of Glasgow is investigating how the various pre-integration components work together in a variety of e-Science projects. The EPSRC-funded nanoCMOS project aims to allow electronics designers and manufacturers to use e-Science technologies and expertise to solve problems of device variability and its impact on system design. To support the security requirements of nanoCMOS, two NeSC projects (VPMan and OMII-SP) are providing tools to allow easy configuration of security infrastructures, exploiting previous successful projects using Shibboleth and PERMIS. This paper presents the model in which these tools interoperate to provide secure and simple access to Grid resources for non-technical users

    Caspase-mediated cleavage of raptor participates in the inactivation of mTORC1 during cell death.

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    The mammalian target of rapamycin complex 1 (mTORC1) is a highly conserved protein complex regulating key pathways in cell growth. Hyperactivation of mTORC1 is implicated in numerous cancers, thus making it a potential broad-spectrum chemotherapeutic target. Here, we characterized how mTORC1 responds to cell death induced by various anticancer drugs such rapamycin, etoposide, cisplatin, curcumin, staurosporine and Fas ligand. All treatments induced cleavage in the mTORC1 component, raptor, resulting in decreased raptor-mTOR interaction and subsequent inhibition of the mTORC1-mediated phosphorylation of downstream substrates (S6K and 4E-BP1). The cleavage was primarily mediated by caspase-6 and occurred at two sites. Mutagenesis at one of these sites, conferred resistance to cell death, indicating that raptor cleavage is important in chemotherapeutic apoptosis

    Integrating security solutions to support nanoCMOS electronics research

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    The UK Engineering and Physical Sciences Research Council (EPSRC) funded Meeting the Design Challenges of nanoCMOS Electronics (nanoCMOS) is developing a research infrastructure for collaborative electronics research across multiple institutions in the UK with especially strong industrial and commercial involvement. Unlike other domains, the electronics industry is driven by the necessity of protecting the intellectual property of the data, designs and software associated with next generation electronics devices and therefore requires fine-grained security. Similarly, the project also demands seamless access to large scale high performance compute resources for atomic scale device simulations and the capability to manage the hundreds of thousands of files and the metadata associated with these simulations. Within this context, the project has explored a wide range of authentication and authorization infrastructures facilitating compute resource access and providing fine-grained security over numerous distributed file stores and files. We conclude that no single security solution meets the needs of the project. This paper describes the experiences of applying X.509-based certificates and public key infrastructures, VOMS, PERMIS, Kerberos and the Internet2 Shibboleth technologies for nanoCMOS security. We outline how we are integrating these solutions to provide a complete end-end security framework meeting the demands of the nanoCMOS electronics domain

    Supercurrent flow through an effective double barrier structure

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    Supercurrent flow is studied in a structure that in the Ginzburg-Landau regime can be described in terms of an effective double barrier potential. In the limit of strongly reflecting barriers, the passage of Cooper pairs through such a structure may be viewed as a realization of resonant tunneling with a rigid wave function. For interbarrier distances smaller than d0=πξ(T)d_0=\pi\xi(T) no current-carrying solutions exist. For distances between d0d_0 and 2d02d_0, four solutions exist. The two symmetric solutions obey a current-phase relation of sin(Δφ/2)\sin(\Delta\varphi/2), while the two asymmetric solutions satisfy Δφ=π\Delta\varphi=\pi for all allowed values of the current. As the distance exceeds nd0nd_0, a new group of four solutions appears, each contaning (n1)(n-1) soliton-type oscillations between the barriers. We prove the inexistence of a continuous crossover between the physical solutions of the nonlinear Ginzburg-Landau equation and those of the corresponding linearized Schr\"odinger equation. We also show that under certain conditions a repulsive delta function barrier may quantitatively describe a SNS structure. We are thus able to predict that the critical current of a SNSNS structure vanishes as TcT\sqrt{T'_c-T}, where TcT'_c is lower than the bulk critical temperature.Comment: 20 pages, RevTex, to appear in Phys. Rev. B, 6 figures on request at [email protected]

    Toeplitz Quantization of K\"ahler Manifolds and gl(N)gl(N) NN\to\infty

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    For general compact K\"ahler manifolds it is shown that both Toeplitz quantization and geometric quantization lead to a well-defined (by operator norm estimates) classical limit. This generalizes earlier results of the authors and Klimek and Lesniewski obtained for the torus and higher genus Riemann surfaces, respectively. We thereby arrive at an approximation of the Poisson algebra by a sequence of finite-dimensional matrix algebras gl(N)gl(N), NN\to\infty.Comment: 17 pages, AmsTeX 2.1, Sept. 93 (rev: only typos are corrected
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