Quantifying the onset of the concentric phase of the force–time record during jumping

Thirteen college students performed a drop jump from height equal to their peak vertical jump, single leg jumps from the left and right legs, and a counter movement jump. Vertical ground reaction force (GRF) obtained via an AMTI force plate and video analysis of markers placed on the hip, knee, lateral malleolus, and fifth metatarsal were used to estimate reaction forces on the knee joint. One-way Repeated Measures ANOVA indicated no differences for knee joint reaction forces relative to body weight or peak GRF for any of the jumps (p \u3e 0.05). Average measures Intraclass Correlation Coefficients ranged from r = 0.90 to 0.97. Results indicate that peak GRF and knee joint reaction forces during the drop jump, counter movement jump, and single leg left and right leg jumps are reliable measures

The relationship between cupric ion activity and the toxicity of copper to phytoplankton

Culture experiments with the estuarine diatom Thalassiosira pseudonana (clone 3H) in highly chelated seawater media demonstrate that growth rate inhibition and copper content of cells are related to cupric ion activity, and not to total copper concentration. Cupric ion activity was altered independently of total copper concentration by varying the chelator concentration, and the pH...

Hierarchical Concurrent Engineering in a Multiagent Framework

Our experience indicates coordination in concurrent engineering (CE) requires support for two types of relationships among decision makers supervisor/subordinate and peer-to-peer Supervisor/subordinate relationships are created by the standard hierarchical decomposition process that is required to solve any large design problem Peer-to-peer relationships arise when teams of decision makers must interact, without direct guidance, to achieve individual and common goals In this paper, we describe a general decision-making methodology, which we call hierarchical CE The emphasis of hierarchical CE is to provide support for both supervisor/subordinate and peer-to-peer relationships In addition to the concept of hierarchical CE, we present a supporting agent-based framework in which the preferences and constraints of a design supervi sor are distributed to design subordinates, who are expected to exploit their local expertise within the context provided by this global information A distinct separation between feasibility and value facilitates optimal decision-making by design agents, since the bounds on feasibility do not include arbitrary statements about value This distinction may prove useful for other problem domains as wellPeer Reviewedhttp://deepblue.lib.umich.edu/bitstream/2027.42/68258/2/10.1177_1063293X9600400105.pd

Optimization and Dose Estimation of Aerosol Delivery to Non-Human Primates

Background: In pre-clinical animal studies, the uniformity of dosing across subjects and routes of administration is a crucial requirement. In preparation for a study in which aerosolized live-attenuated measles virus vaccine was administered to cynomolgus monkeys (Macaca fascicularis) by inhalation, we assessed the percentage of a nebulized dose inhaled under varying conditions. Methods: Drug delivery varies with breathing parameters. Therefore we determined macaque breathing patterns (tidal volume, breathing frequency, and inspiratory to expiratory (I:E) ratio) across a range of 3.3-6.5 kg body weight, using a pediatric pneumotachometer interfaced either with an endotracheal tube or a facemask. Subsequently, these breathing patterns were reproduced using a breathing simulator attached to a filter to collect the inhaled dose. Albuterol was nebulized using a vibrating mesh nebulizer and the percentage inhaled dose was determined by extraction of drug from the filter and subsequent quantification. Results: Tidal volumes ranged from 24 to 46 mL, breathing frequencies from 19 to 31 breaths per minute and I:E ratios from 0.7 to 1.6. A small pediatric resuscitation mask was identified as the best fitting interface between animal and pneumotachometer. The average efficiency of inhaled dose delivery was 32.1% (standard deviation 7.5, range 24%-48%), with variation in tidal volumes as the most important determinant. Conclusions: Studies in non-human primates aimed at comparing aerosol delivery with other routes of administration should take both the inter-subject variation and relatively low efficiency of delivery to these low body weight mammals into account

Room-Scale CO2 Injections in a Physical Reservoir Model with Faults

We perform a series of repeated CO2 injections in a room-scale physical model of a faulted geological cross-section. Relevant parameters for subsurface carbon storage, including multiphase flows, capillary CO2 trapping, dissolution and convective mixing, are studied and quantified. As part of a validation benchmark study, we address and quantify six predefined metrics for storage capacity and security in typical CO2 storage operations. Using the same geometry, we investigate the degree of reproducibility of five repeated experimental runs. Our analysis focuses on physical variations of the spatial distribution of mobile and dissolved CO2, multiphase flow patterns, development in mass of the aqueous and gaseous phases, gravitational fingers and leakage dynamics. We observe very good reproducibility in homogenous regions with up to 97% overlap between repeated runs, and that fault-related heterogeneity tends to decrease reproducibility. Notably, we observe an oscillating CO2 leakage behavior from the spill point of an anticline and discuss the observed phenomenon within the constraints of the studied system.publishedVersio

Mode-Locking in Driven Disordered Systems as a Boundary-Value Problem

We study mode-locking in disordered media as a boundary-value problem. Focusing on the simplest class of mode-locking models which consists of a single driven overdamped degree-of-freedom, we develop an analytical method to obtain the shape of the Arnol'd tongues in the regime of low ac-driving amplitude or high ac-driving frequency. The method is exact for a scalloped pinning potential and easily adapted to other pinning potentials. It is complementary to the analysis based on the well-known Shapiro's argument that holds in the perturbative regime of large driving amplitudes or low driving frequency, where the effect of pinning is weak.Comment: 6 pages, 7 figures, RevTeX, Submitte