Real time thermal propagtors for massive gauge bosons

We derive Feynman rules for gauge theories exhibiting spontaneous symmetry breaking using the real-time formalism of finite temperature field theory. We also derive the thermal propagators where only the physical degrees of freedom are given thermal boundary conditions. We analyse the abelian Higgs model and find that these new propagators simplify the calculation of the thermal contribution to the self energy.Comment: 7 pages, late

Black Thunder Coal Mine and Los Alamos National Laboratory experimental study of seismic energy generated by large scale mine blasting

In an attempt to better understand the impact that large mining shots will have on verifying compliance with the international, worldwide, Comprehensive Test Ban Treaty (CTBT, no nuclear explosion tests), a series of seismic and videographic experiments has been conducted during the past two years at the Black Thunder Coal Mine. Personnel from the mine and Los Alamos National Laboratory have cooperated closely to design and perform experiments to produce results with mutual benefit to both organizations. This paper summarizes the activities, highlighting the unique results of each. Topics which were covered in these experiments include: (1) synthesis of seismic, videographic, acoustic, and computer modeling data to improve understanding of shot performance and phenomenology; (2) development of computer generated visualizations of observed blasting techniques; (3) documentation of azimuthal variations in radiation of seismic energy from overburden casting shots; (4) identification of, as yet unexplained, out of sequence, simultaneous detonation in some shots using seismic and videographic techniques; (5) comparison of local (0.1 to 15 kilometer range) and regional (100 to 2,000 kilometer range) seismic measurements leading to determine of the relationship between local and regional seismic amplitude to explosive yield for overburden cast, coal bulking and single fired explosions; and (6) determination of the types of mining shots triggering the prototype International Monitoring System for the CTBT

First Measurement of A_N at sqrt(s)=200 GeV in Polarized Proton-Proton Elastic Scattering at RHIC

We report on the first measurement of the single spin analyzing power (A_N) at sqrt(s)=200GeV, obtained by the pp2pp experiment using polarized proton beams at the Relativistic Heavy Ion Collider (RHIC). Data points were measured in the four momentum transfer t range 0.01 < |t| < 0.03 (GeV/c)^2. Our result, averaged over the whole t-interval is about one standard deviation above the calculation, which uses interference between electromagnetic spin-flip amplitude and hadronic non-flip amplitude, the source of A_N. The difference could be explained by an additional contribution of a hadronic spin-flip amplitude to A_N.Comment: 13 pages, 5 figures. New values of polarization errors. Final version submitted to Phys. Lett.

First Measurement of Proton-Proton Elastic Scattering at RHIC

The first result of the pp2pp experiment at RHIC on elastic scattering of polarized protons at sqrt{s} = 200 GeV is reported here. The exponential slope parameter b of the diffractive peak of the elastic cross section in the t range 0.010 <= |t| <= 0.019 (GeV/c)^2 was measured to be b = 16.3 +- 1.6 (stat.) +- 0.9 (syst.) (GeV/c)^{-2} .Comment: 9 pages 5 figure

Active Galactic Nuclei at the Crossroads of Astrophysics

Over the last five decades, AGN studies have produced a number of spectacular examples of synergies and multifaceted approaches in astrophysics. The field of AGN research now spans the entire spectral range and covers more than twelve orders of magnitude in the spatial and temporal domains. The next generation of astrophysical facilities will open up new possibilities for AGN studies, especially in the areas of high-resolution and high-fidelity imaging and spectroscopy of nuclear regions in the X-ray, optical, and radio bands. These studies will address in detail a number of critical issues in AGN research such as processes in the immediate vicinity of supermassive black holes, physical conditions of broad-line and narrow-line regions, formation and evolution of accretion disks and relativistic outflows, and the connection between nuclear activity and galaxy evolution.Comment: 16 pages, 5 figures; review contribution; "Exploring the Cosmic Frontier: Astrophysical Instruments for the 21st Century", ESO Astrophysical Symposia Serie

The treatment of polycythaemia vera: an update in the JAK2 era

The clinical course of polycythaemia vera is marked by a high incidence of thrombotic complications, which represent the main cause of morbidity and mortality. Major predictors of vascular events are increasing age and previous thrombosis. Myelosuppressive drugs can reduce the rate of thrombosis, but there is concern that their use raises the risk of transformation into acute leukaemia. To tackle this dilemma, a risk-oriented management strategy is recommended. Low-risk patients should be treated with phlebotomy and low-dose aspirin. Cytotoxic therapy is indicated in high-risk patients, with the drug of choice being hydroxyurea because its leukaemogenicity is low. The recent discovery of JAK2 V617F mutation in the vast majority of polycythaemia vera patients opens new avenues for the treatment of this disease. Novel therapeutic options theoretically devoid of leukaemic risk, such as alpha-interferon and imatinib, affect JAK2 expression in some patients. Nevertheless, these drugs require further clinical experience and, for the time being, should be reserved for selected cases

A Model for the Development of the Rhizobial and Arbuscular Mycorrhizal Symbioses in Legumes and Its Use to Understand the Roles of Ethylene in the Establishment of these two Symbioses

We propose a model depicting the development of nodulation and arbuscular mycorrhizae. Both processes are dissected into many steps, using Pisum sativum L. nodulation mutants as a guideline. For nodulation, we distinguish two main developmental programs, one epidermal and one cortical. Whereas Nod factors alone affect the cortical program, bacteria are required to trigger the epidermal events. We propose that the two programs of the rhizobial symbiosis evolved separately and that, over time, they came to function together. The distinction between these two programs does not exist for arbuscular mycorrhizae development despite events occurring in both root tissues. Mutations that affect both symbioses are restricted to the epidermal program. We propose here sites of action and potential roles for ethylene during the formation of the two symbioses with a specific hypothesis for nodule organogenesis. Assuming the epidermis does not make ethylene, the microsymbionts probably first encounter a regulatory level of ethylene at the epidermis–outermost cortical cell layer interface. Depending on the hormone concentrations there, infection will either progress or be blocked. In the former case, ethylene affects the cortex cytoskeleton, allowing reorganization that facilitates infection; in the latter case, ethylene acts on several enzymes that interfere with infection thread growth, causing it to abort. Throughout this review, the difficulty of generalizing the roles of ethylene is emphasized and numerous examples are given to demonstrate the diversity that exists in plants

Psychology and aggression

Peer Reviewedhttp://deepblue.lib.umich.edu/bitstream/2027.42/68264/2/10.1177_002200275900300301.pd

The genetic architecture of the human cerebral cortex

INTRODUCTION The cerebral cortex underlies our complex cognitive capabilities. Variations in human cortical surface area and thickness are associated with neurological, psychological, and behavioral traits and can be measured in vivo by magnetic resonance imaging (MRI). Studies in model organisms have identified genes that influence cortical structure, but little is known about common genetic variants that affect human cortical structure. RATIONALE To identify genetic variants associated with human cortical structure at both global and regional levels, we conducted a genome-wide association meta-analysis of brain MRI data from 51,665 individuals across 60 cohorts. We analyzed the surface area and average thickness of the whole cortex and 34 cortical regions with known functional specializations. RESULTS We identified 306 nominally genome-wide significant loci (P < 5 × 10−8) associated with cortical structure in a discovery sample of 33,992 participants of European ancestry. Of the 299 loci for which replication data were available, 241 loci influencing surface area and 14 influencing thickness remained significant after replication, with 199 loci passing multiple testing correction (P < 8.3 × 10−10; 187 influencing surface area and 12 influencing thickness). Common genetic variants explained 34% (SE = 3%) of the variation in total surface area and 26% (SE = 2%) in average thickness; surface area and thickness showed a negative genetic correlation (rG = −0.32, SE = 0.05, P = 6.5 × 10−12), which suggests that genetic influences have opposing effects on surface area and thickness. Bioinformatic analyses showed that total surface area is influenced by genetic variants that alter gene regulatory activity in neural progenitor cells during fetal development. By contrast, average thickness is influenced by active regulatory elements in adult brain samples, which may reflect processes that occur after mid-fetal development, such as myelination, branching, or pruning. When considered together, these results support the radial unit hypothesis that different developmental mechanisms promote surface area expansion and increases in thickness. To identify specific genetic influences on individual cortical regions, we controlled for global measures (total surface area or average thickness) in the regional analyses. After multiple testing correction, we identified 175 loci that influence regional surface area and 10 that influence regional thickness. Loci that affect regional surface area cluster near genes involved in the Wnt signaling pathway, which is known to influence areal identity. We observed significant positive genetic correlations and evidence of bidirectional causation of total surface area with both general cognitive functioning and educational attainment. We found additional positive genetic correlations between total surface area and Parkinson’s disease but did not find evidence of causation. Negative genetic correlations were evident between total surface area and insomnia, attention deficit hyperactivity disorder, depressive symptoms, major depressive disorder, and neuroticism. CONCLUSION This large-scale collaborative work enhances our understanding of the genetic architecture of the human cerebral cortex and its regional patterning. The highly polygenic architecture of the cortex suggests that distinct genes are involved in the development of specific cortical areas. Moreover, we find evidence that brain structure is a key phenotype along the causal pathway that leads from genetic variation to differences in general cognitive function