Magnetic relaxation in the "Bragg-glass" phase in BSCCO

Magnetic relaxation in the Bragg-glass phase of overdoped Bi_2Sr_2CaCu_2O_8 crystals was investigated using time-resolved magneto-optical visualisation of the flux distribution. This has permitted us to extract the current-voltage characteristic, which can be well described by a power-law, although fits to a stretched exponential E \sim \exp(- j_{c} / j)^{\mu} with 0.3 < \mu < 0.8 are possible at long times in excess of 100 s.Comment: 2 pages, 3 figures submitted to conference proceedings of M2S-2000 Houston T

LncRNA-OIS1 regulates DPP4 activation to modulate senescence induced by RAS

Oncogene-induced senescence (OIS), provoked in response to oncogenic activation, is considered an important tumor suppressor mechanism. Long noncoding RNAs (lncRNAs) are transcripts longer than 200 nt without a protein-coding capacity. Functional studies showed that deregulated lncRNA expression promote tumorigenesis and metastasis and that lncRNAs may exhibit tumor-suppressive and oncogenic function. Here, we first identified lncRNAs that were differentially expressed between senescent and non-senescent human fibroblast cells. Using RNA interference, we performed a loss-function screen targeting the differentially expressed lncRNAs, and identified lncRNA-OIS1 (lncRNA#32, AC008063.3 or ENSG00000233397) as a lncRNA required for OIS. Knockdown of lncRNA-OIS1 triggered bypass of senescence, higher proliferation rate, lower abundance of the cell-cycle inhibitor CDKN1A and high expression of cell-cycle-associated genes. Subcellular inspection of lncRNA-OIS1 indicated nuclear and cytosolic localization in both normal culture conditions as well as following oncogene induction. Interestingly, silencing lncRNA-OIS1 diminished the senescent-associated induction of a nearby gene (Dipeptidyl Peptidase 4, DPP4) with established role

Interplay of pancake vortices and columnar defects in heavy-ion irradiated Bi-2212

International audienceAn analysis of equilibrium magnetization curves of Bi2Sr2CaCu2O8+d with different doses of columnar tracks reveals the distribution of pancake vortices on columnar pinning sites. In addition, core pinning is found to be the prevailing interaction mechanism between pancake vortices and columnar defects. © 2000 Elsevier Science B.V. All rights reserved