Electron correlation effects in a wide channel from the ν=1\nu =1 quantum Hall edge states

The spatial behavior of Landau levels (LLs) for the $nu=1$ quantum Hall regime at the edge of a wide channel is studied in a self-consistent way by using a generalized local density approximation proposed here. Both exchange interaction and strong electron correlations, due to edge states, are taken into account. They essentially modify the spatial behavior of the occupied lowest spin-up LL in comparison with that of the lowest spin-down LL, which is totally empty. The contrast in the spatial behavior can be attributed to a different effective one-electron lateral confining potentials for the spin-split LLs. Many-body effects on the spatially inhomogeneous spin-splitting are calculated within the screened Hartree-Fock approximation. It is shown that, far from the edges, the maximum activation energy is dominated by the gap between the Fermi level and the bottom of the spin-down LL, because the gap between the Fermi level and the spin-up LL is much larger. In other words, the maximum activation energy in the bulk of the channel corresponds to a highly asymmetric position of the Fermi level within the gap between spin-down and spin-up LLs in the bulk. We have also studied the renormalization of the edge-state group velocity due to electron correlations. The results of the present theory are in line with those suggested and reported by experiments on high quality samples.Comment: 9 pages, 4 figure

Growth and Post-Deposition Treatments of SrTiO3 Films for Dye-Sensitized Photoelectrosynthesis Cell Applications

Sensitized SrTiO3 films were evaluated as potential photoanodes for dye-sensitized photoelectrosynthesis cells (DSPECs). The SrTiO3 films were grown via pulsed laser deposition (PLD) on a transparent conducting oxide (fluorine-doped tin oxide, FTO) substrate, annealed, and then loaded with zinc(II) 5,10,15-tris(mesityl)-20-[(dihydroxyphosphoryl)phenyl] porphyrin (MPZnP). When paired with a platinum wire counter electrode and an Ag/AgCl reference electrode these sensitized films exhibited photocurrent densities on the order of 350 nA/cm2 under 0 V applied bias conditions versus a normal hydrogen electrode (NHE) and 75 mW/cm2 illumination at a wavelength of 445 nm. The conditions of the post-deposition annealing step - namely, a high-temperature reducing atmosphere - proved to be the most important growth parameters for increasing photocurrent in these electrodes

The Effects of Disorder on the ν=1\nu=1 Quantum Hall State

A disorder-averaged Hartree-Fock treatment is used to compute the density of single particle states for quantum Hall systems at filling factor $\nu=1$. It is found that transport and spin polarization experiments can be simultaneously explained by a model of mostly short-range effective disorder. The slope of the transport gap (due to quasiparticles) in parallel field emerges as a result of the interplay between disorder-induced broadening and exchange, and has implications for skyrmion localization.Comment: 4 pages, 3 eps figure

Zanamivir susceptibility monitoring and characterization of influenza virus clinical isolates obtained during phase II clinical efficacy studies

Zanamivir is a highly selective neuraminidase (NA) inhibitor with demonstrated clinical efficacy against influenza A and B virus infections. In phase II clinical efficacy trials (NAIB2005 and NAIB2008), virological substudies showed mean reductions in virus shedding after 24 h of treatment of 1.5 to 2.0 log(10) 50% tissue culture infective doses compared to a placebo, with no reemergence of virus after the completion of therapy. Paired isolates (n = 41) obtained before and during therapy with zanamivir demonstrated no shifts in susceptibility to zanamivir when measured by NA assays, although for a few isolates NA activity was too low to evaluate. In plaque reduction assays in MDCK cells, the susceptibility of isolates to zanamivir was extremely variable even at baseline and did not correlate with the speed of resolution of virus shedding. Isolates with apparent limited susceptibility to zanamivir by plaque reduction proved highly susceptible in vivo in the ferret model. Further sequence analysis of paired isolates revealed no changes in the hemagglutinin and NA genes in the majority of isolates. The few changes observed were all natural variants. No amino acid changes that had previously been identified in vitro as being involved with reduced susceptibility to zanamivir were observed. These studies highlighted problems associated with monitoring susceptibility to NA inhibitors in the clinic, in that no reliable cell-based assay is available. At present the NA assay is the best available predictor of susceptibility to NA inhibitors in vivo, as measured in the validated ferret model of infection

The HI/OH/Recombination line survey of the inner Milky Way (THOR): data release 2 and Hi overview

Context. The Galactic plane has been observed extensively by a large number of Galactic plane surveys from infrared to radio wavelengths at an angular resolution below 40". However, a 21 cm line and continuum survey with comparable spatial resolution is still missing. Aims. The first half of THOR data (l = 14.0 37.9, and l = 47.1 51.2, |b| < 1.25) has been published in our data release 1 paper (Beuther et al. 2016). With this data release 2 paper, we publish all the remaining spectral line data and Stokes I continuum data with high angular resolution (1000–4000) including a new H i dataset for the whole THOR survey region (l = 14.0 67.4 and |b| < 1.25). As we have published the results of OH lines and continuum emission elsewhere, we concentrate on the H i analysis in this paper. Methods. With the Karl G. Jansky Very Large Array (VLA) in C-configuration, we observed a large portion of the first Galactic quadrant achieving an angular resolution of < 40. At L Band, the WIDAR correlator at the VLA was set to cover the 21 cm H i line, four OH transitions, a series of Hn↵ radio recombination lines (RRLs; n = 151 to 186), and eight 128 MHz wide continuum spectral windows (SPWs) simultaneously. Results. We publish all OH and RRL data from the C-configuration observations, and a new H i dataset combining VLA C+D+GBT (VLA D-configuration and GBT data are from the VLA Galactic Plane Survey, Stil et al. 2006) for the whole survey. The H i emission shows clear filamentary substructures at negative velocities with low velocity crowding. The emission at positive velocities is more smeared-out likely due to higher spatial and velocity crowding of structures at the positive velocities. Comparing to the spiral arm model of the Milky Way, the atomic gas follows the Sagittarius and Perseus Arm well but with significant material in the inter-arm regions. With the C-configuration-only H i+continuum data, we produced a H i optical depth map of the THOR areal coverage from 228 absorption spectra with the nearest-neighbor method. With this ⌧ map, we corrected the H i emission for optical depth and the derived column density is 38% higher than the column density with optically thin assumption. The total H i mass with optical depth correction in the survey region is 4.7⇥108 M, 31% more than the mass derived assuming the emission is optically thin. If we apply this 31% correction to the whole Milky Way, the total atomic gas mass would be 9.4–10.5⇥109 M. Comparing the H i with existing CO data, we find a significant increase in the atomic-to-molecular gas ration from the spiral arms to the inter-arm regions. Conclusions. The high sensitivity and resolution THOR H i dataset provides an important new window on the physical and kinematic properties of gas in the inner Galaxy. Although the optical depth we derive is a lower limit, our study shows that the optical depth correction is significant for H i column density and mass estimation. Together with the OH, RRL and continuum emission from the THOR survey, these new H i data provide the basis for high angular-resolution studies of the interstellar medium (ISM) in different phases

Leukocyte gene expression signatures in antineutrophil cytoplasmic autoantibody and lupus glomerulonephritis

Leukocytes play a major role in the development and progression of autoimmune diseases. We measured gene expression differences in leukocytes from patients that were antineutrophil cytoplasmic autoantibody (ANCA) positive, patients with systemic lupus erythematosus (SLE) or rheumatoid arthritis (RA), and healthy donors to explore potential pathways for clinical intervention. Leukocyte gene expression profiles were determined on Affymetrix U133A/B chips in 88 autoimmune patients, 28 healthy donors, and healthy donor leukocyte cell subtypes that were activated . Comparison of gene expression in leukocytes identified differentially expressed signature genes that distinguish each donor source. The microarray expression levels for many signature genes correlated with the clinical activity of small vessel vasculitis in the ANCA patients; a result confirmed by quantitative real time-polymerase chain reaction for 16 relevant genes. Comparison with -activated leukocyte subtypes from healthy donors revealed that the ANCA signature genes were expressed by neutrophils while the SLE signature genes were expressed in activated monocytes and T cells. We have found that leukocyte gene expression data can differentiate patients with RA, SLE, and ANCA-related small vessel vasculitis. Monitoring changes in the expression of specific genes may be a tool to help quantify disease activity during treatment

Effects of eight neuropsychiatric copy number variants on human brain structure

peer reviewedMany copy number variants (CNVs) confer risk for the same range of neurodevelopmental symptoms and psychiatric conditions including autism and schizophrenia. Yet, to date neuroimaging studies have typically been carried out one mutation at a time, showing that CNVs have large effects on brain anatomy. Here, we aimed to characterize and quantify the distinct brain morphometry effects and latent dimensions across 8 neuropsychiatric CNVs. We analyzed T1-weighted MRI data from clinically and non-clinically ascertained CNV carriers (deletion/duplication) at the 1q21.1 (n = 39/28), 16p11.2 (n = 87/78), 22q11.2 (n = 75/30), and 15q11.2 (n = 72/76) loci as well as 1296 non-carriers (controls). Case-control contrasts of all examined genomic loci demonstrated effects on brain anatomy, with deletions and duplications showing mirror effects at the global and regional levels. Although CNVs mainly showed distinct brain patterns, principal component analysis (PCA) loaded subsets of CNVs on two latent brain dimensions, which explained 32 and 29% of the variance of the 8 Cohen’s d maps. The cingulate gyrus, insula, supplementary motor cortex, and cerebellum were identified by PCA and multi-view pattern learning as top regions contributing to latent dimension shared across subsets of CNVs. The large proportion of distinct CNV effects on brain morphology may explain the small neuroimaging effect sizes reported in polygenic psychiatric conditions. Nevertheless, latent gene brain morphology dimensions will help subgroup the rapidly expanding landscape of neuropsychiatric variants and dissect the heterogeneity of idiopathic conditions. © 2021, The Author(s)