Sterile neutrinos with eV masses in cosmology -- how disfavoured exactly?

We study cosmological models that contain sterile neutrinos with eV-range masses as suggested by reactor and short-baseline oscillation data. We confront these models with both precision cosmological data (probing the CMB decoupling epoch) and light-element abundances (probing the BBN epoch). In the minimal LambdaCDM model, such sterile neutrinos are strongly disfavoured by current data because they contribute too much hot dark matter. However, if the cosmological framework is extended to include also additional relativistic degrees of freedom -- beyond the three standard neutrinos and the putative sterile neutrinos, then the hot dark matter constraint on the sterile states is considerably relaxed. A further improvement is achieved by allowing a dark energy equation of state parameter w<-1. While BBN strongly disfavours extra radiation beyond the assumed eV-mass sterile neutrino, this constraint can be circumvented by a small nu_e degeneracy. Any model containing eV-mass sterile neutrinos implies also strong modifications of other cosmological parameters. Notably, the inferred cold dark matter density can shift up by 20 to 75% relative to the standard LambdaCDM value.Comment: 14 pages, 6 figures, v2: minor changes, matches version accepted for publication in JCA

An analytic model for a cooperative ballistic deposition in one dimension

We formulate a model for a cooperative ballistic deposition (CBD) process whereby the incoming particles are correlated with the ones already adsorbed via attractive force. The strength of the correlation is controlled by a tunable parameter $a$ that interpolates the classical car parking problem at $a=0$, the ballistic deposition at $a=1$ and the CBD model at $a>1$. The effects of the correlation in the CBD model are as follows. The jamming coverage $q(a)$ increases with the strength of attraction $a$ due to an ever increasing tendency of cluster formation. The system almost reaches the closest packing structure as $a\to\infty$ but never forms a percolating cluster which is typical to 1D system. In the large $a$ regime, the mean cluster size $k$ increases as $a^{1/2}$. Furthermore, the asymptotic approach towards the closest packing is purely algebraic both with $a$ as $q(\infty)-q(a) \sim a^{-1/2}$ and with $k$ as $q(\infty)-q(k) \sim k^{-1}$ where $q(\infty)\simeq 1$.Comment: 9 pages (in Revtex4), 9 eps figures; Submitted to publicatio

UNITSIM-Galaxies: Data release and clustering of emission-line galaxies

This is a pre-copyedited, author-produced PDF of an article accepted for publication in Monthly Notices of the Royal Astronomical Society following peer review. The version of record Monthly Notices of the Royal Astronomical Society 510.4 (2022): 5392-5407 is available online at: https://academic.oup.com/mnras/article-abstract/510/4/5392/6505155?redirectedFrom=fulltextNew surv e ys such as European Space Agenc ys (ESA's) Euclid mission are planned to map with unprecedented precision the large-scale structure of the Universe by measuring the 3D positions of tens of millions of galaxies. It is necessary to develop theoretically modelled galaxy catalogues to estimate the expected performance and to optimize the analysis strategy of these surv e ys. We populate two pairs of (1 h -1 Gpc) 3 volume dark matter-only simulations from the UNIT project with galaxies using the Semi-Analytic Galaxy Evolution semi-analytic model of galaxy formation, coupled to the photoionization model GET EMLINES to estimate their H αemission. These catalogues represent a unique suite that includes galaxy formation physics and -thanks to the fixed-pair technique used -an ef fecti ve volume of ∼(5 h -1 Gpc ) 3 , which is several times larger than the Euclid surv e y. We present the performance of these data and create five additional emission-line galaxy (ELG) catalogues by applying a dust-attenuation model as well as adjusting the flux threshold as a function of redshift in order to reproduce Euclid-forecast d N /d z values. As a first application, we study the abundance and clustering of those model H αELGs: For scales greater than ∼5 h -1 Mpc, we find a scale- independent bias with a value of b ∼1 at redshift z ∼0.5, that can increase nearly linearly to b ∼4 at z ∼2, depending on the ELG catalogue. Model galaxy properties, including their emission-line fluxes (with and without dust extinction) are publicly availabl

Kinetics and Jamming Coverage in a Random Sequential Adsorption of Polymer Chains

Using a highly efficient Monte Carlo algorithm, we are able to study the growth of coverage in a random sequential adsorption (RSA) of self-avoiding walk (SAW) chains for up to 10^{12} time steps on a square lattice. For the first time, the true jamming coverage (theta_J) is found to decay with the chain length (N) with a power-law theta_J propto N^{-0.1}. The growth of the coverage to its jamming limit can be described by a power-law, theta(t) approx theta_J -c/t^y with an effective exponent y which depends on the chain length, i.e., y = 0.50 for N=4 to y = 0.07 for N=30 with y -> 0 in the asymptotic limit N -> infinity.Comment: RevTeX, 5 pages inclduing figure

Automated Coronal Hole Detection using Local Intensity Thresholding Techniques

We identify coronal holes using a histogram-based intensity thresholding technique and compare their properties to fast solar wind streams at three different points in the heliosphere. The thresholding technique was tested on EUV and X-ray images obtained using instruments onboard STEREO, SOHO and Hinode. The full-disk images were transformed into Lambert equal-area projection maps and partitioned into a series of overlapping sub-images from which local histograms were extracted. The histograms were used to determine the threshold for the low intensity regions, which were then classified as coronal holes or filaments using magnetograms from the SOHO/MDI. For all three instruments, the local thresholding algorithm was found to successfully determine coronal hole boundaries in a consistent manner. Coronal hole properties extracted using the segmentation algorithm were then compared with in situ measurements of the solar wind at 1 AU from ACE and STEREO. Our results indicate that flux tubes rooted in coronal holes expand super-radially within 1 AU and that larger (smaller) coronal holes result in longer (shorter) duration high-speed solar wind streams

Gravitational Coupling and Dynamical Reduction of The Cosmological Constant

We introduce a dynamical model to reduce a large cosmological constant to a sufficiently small value. The basic ingredient in this model is a distinction which has been made between the two unit systems used in cosmology and particle physics. We have used a conformal invariant gravitational model to define a particular conformal frame in terms of large scale properties of the universe. It is then argued that the contributions of mass scales in particle physics to the vacuum energy density should be considered in a different conformal frame. In this manner, a decaying mechanism is presented in which the conformal factor appears as a dynamical field and plays a key role to relax a large effective cosmological constant. Moreover, we argue that this model also provides a possible explanation for the coincidence problem.Comment: To appear in GR

Protein sequence and structure: Is one more fundamental than the other?

We argue that protein native state structures reside in a novel "phase" of matter which confers on proteins their many amazing characteristics. This phase arises from the common features of all globular proteins and is characterized by a sequence-independent free energy landscape with relatively few low energy minima with funnel-like character. The choice of a sequence that fits well into one of these predetermined structures facilitates rapid and cooperative folding. Our model calculations show that this novel phase facilitates the formation of an efficient route for sequence design starting from random peptides.Comment: 7 pages, 4 figures, to appear in J. Stat. Phy

Prevalence of left ventricular diastolic dysfunction in a general population

BACKGROUND: Because the process of myocardial remodelling starts before the onset of symptoms, recent heart failure (HF) guidelines place special emphasis on the detection of subclinical left ventricular (LV) systolic and diastolic dysfunction and the timely identification of risk factors for HF. Our goal was to describe the prevalence and determinants (risk factors) of LV diastolic dysfunction in a general population and to compare the amino terminal probrain natriuretic peptide level across groups with and without diastolic dysfunction. METHODS AND RESULTS: In a randomly recruited population sample (n=539; 50.5% women; mean age, 52.5 years), we measured early and late diastolic peak velocities of mitral inflow (E and A), pulmonary vein flow by pulsed-wave Doppler, and the mitral annular velocities (Ea and Aa) at 4 sites by tissue Doppler imaging. A healthy subsample of 239 subjects (mean age, 43.7 years) provided age-specific cutoff limits for normal E/A and E/Ea ratios and the differences in duration between the mitral A and the reverse pulmonary vein flows during atrial systole (DeltaAd-ARd). The number of subjects in diastolic dysfunction groups 1 (impaired relaxation), 2 (elevated LV end-diastolic filling pressure), and 3 (elevated E/Ea and abnormally low E/A) were 53 (9.8%), 76 (14.1%), and 18 (3.4%), respectively. We used Delta(Ad<ARd+10) to confirm possible elevation of LV filling pressures in group 2. Compared with subjects with normal diastolic function (n=392, 72.7%), group 1 (209 versus 251 pmol/L; P=0.015) and group 2 (209 versus 275 pmol/L; P=0.0003) but not group 3 (209 versus 224 pmol/L; P=0.65) had a significantly higher adjusted NT-probrain natriuretic peptide. Higher age, body mass index, heart rate, systolic blood pressure, serum insulin, and creatinine were significantly associated with a higher risk of LV diastolic dysfunction. CONCLUSIONS: The overall prevalence of LV diastolic dysfunction in a random sample of a general population, as estimated from echocardiographic measurements, was as high as 27.3%

Exact diagonalization of the generalized supersymmetric t-J model with boundaries

We study the generalized supersymmetric $t-J$ model with boundaries in three different gradings: FFB, BFF and FBF. Starting from the trigonometric R-matrix, and in the framework of the graded quantum inverse scattering method (QISM), we solve the eigenvalue problems for the supersymmetric $t-J$ model. A detailed calculations are presented to obtain the eigenvalues and Bethe ansatz equations of the supersymmetric $t-J$ model with boundaries in three different backgrounds.Comment: Latex file, 32 page

Association between Nephrotoxic Drug Combinations and Acute Kidney Injury in the Neonatal Intensive Care Unit

Objective: To determine the incidence of acute kidney injury (AKI) in infants exposed to nephrotoxic drug combinations admitted to 268 neonatal intensive care units managed by the Pediatrix Medical Group. Study design: We included infants born at 22-36 weeks gestational age, ≤120 days postnatal age, exposed to nephrotoxic drug combinations, with serum creatinine measurements available, and discharged between 2007 and 2016. To identify risk factors associated with a serum creatinine definition of AKI based on the Kidney Disease: Improving Global Outcomes criteria, we performed multivariable logistic and Cox regression adjusting for gestational age, sex, birth weight, postnatal age, race/ethnicity, sepsis, respiratory distress syndrome, baseline serum creatinine, and duration of combination drug exposure. The adjusted odds of AKI were determined relative to gentamicin + indomethacin for the following nephrotoxic drug combinations: chlorothiazide + ibuprofen; chlorothiazide + indomethacin; furosemide + gentamicin; furosemide + ibuprofen; furosemide + tobramycin; ibuprofen + spironolactone; and vancomycin + piperacillin-tazobactam. Results: Among 8286 included infants, 1384 (17%) experienced AKI. On multivariable analysis, sepsis, lower baseline creatinine, and duration of combination therapy were associated with increased odds of AKI. Furosemide + tobramycin and vancomycin + piperacillin-tazobactam were associated with a decreased risk of AKI relative to gentamicin + indomethacin in both the multivariable and Cox regression models. Conclusions: In this cohort, infants receiving longer durations of nephrotoxic combination therapy had an increased odds of developing AKI