Expression Of Class I Major Histocompatibility Complex (mhc I) In The Central Nervous System: Role In Synaptic Plasticity And Regeneration [expressão Do Complexo De Histocompatilidade Principal De Classe I (mhc I) No Sistema Nervoso Central: Plasticidade Sináptica E Regeneração]

It has been recently demonstrated that the major histocompatibility complex of class I (MHC I) expressed in the central nervous system (CNS) does not only function as a molecule of the immune system, but also plays a role in the synaptic plasticity. The expression of MHC I influences the intensity and selectivity of elimination of synapses apposed to neurons that were subjected to lesion, besides influencing the reactivity of neighboring glial cells. MHC I expression and the degree of synaptic rearrangement and glial response after injury correlate with differences in the regenerative potential and functional recovery of isogenic mice strains. In this way, the new aspects regarding MHC I functions in the CNS may guide further studies aiming at searching the involvement of MCH I in neurologic disorders, as well as the development of new therapeutic strategies.92193198Babbitt, B.P., Allen, P.M., Matsueda, G., Binding of immunogenic peptides to Ia histocompatibility molecules (1985) Nature, 317 (6035), pp. 359-361. , DOI 10.1038/317359a0Parnes, J.R., Molecular biology and function of cd4 and cd8 (1989) Adv Immunol, 44, pp. 265-311Gromme, M., Neefjes, J., Antigen degradation or presentation by MHC class i molecules via classical and non-classical pathways (2002) Molecular Immunology, 39 (3-4), pp. 181-202. , DOI 10.1016/S0161-5890(02)00101-3, PII S0161589002001013Neumann, H., Control of glial immune function by neurons (2001) Glia, 36 (2), pp. 191-199. , DOI 10.1002/glia.1108Williams, K.A., Hart, D.N.J., Fabre, J.W., Morris, P.J., Distribution and quantitation of HLA-ABC and DR (Ia) antigens on human kidney and other tissues (1980) Transplantation, 29 (4), pp. 274-279Wong, G.H.W., Bartlett, P.F., Clark-Lewis, I., Inducible expression of H-2 and Ia antigens on brain cells (1984) Nature, 310 (5979), pp. 688-691Linda, H., Hammarberg, H., Cullheim, S., Levinovitz, A., Khademi, M., Olsson, T., Expression of MHC class i and β 2-microglobulin in rat spinal motoneurons: Regulatory influences by IFN-gamma and axotomy (1998) Experimental Neurology, 150 (2), pp. 282-295. , DOI 10.1006/exnr.1997.6768Tran, C.T., Wolz, P., Egensperger, R., Kosel, S., Imai, Y., Bise, K., Kohsaka, S., Graeber, M.B., Differential expression of MHC class II molecules by microglia and neoplastic astroglia: Relevance for the escape of astrocytoma cells from immune surveillance (1998) Neuropathology and Applied Neurobiology, 24 (4), pp. 293-301. , DOI 10.1046/j.1365-2990.1998.00120.xZanon, R.G., Oliveira, A.L., MHC i upregulation influences astroglial reaction and synaptic plasticity in the spinal cord after sciatic nerve transection (2006) Exp Neurol, 200 (2), pp. 521-531Lindsley, M.D., Thiemann, F.L., Rodriguez, M., Expression of class i antigen in C57/BL10 and SJ1 mice following theiler's virus infection (1988) J Neuropathol Exp Neurol, 47, p. 324Gogate, N., Bakhiet, M., Kristensson, K., Norrby, E., Olsson, T., Gamma interferon expression and major histocompatibility complex induction during measles and vesicular stomatitis virus infections of the brain (1991) J Neuroimmunol, 31 (1), pp. 19-26Oliveira, A.L.R., Thams, S., Lidman, O., Piehl, F., Hokfelt, T., Karre, K., Linda, H., Cullheim, S., A role for MHC class i molecules in synaptic plasticity and regeneration of neurons after axotomy (2004) Proceedings of the National Academy of Sciences of the United States of America, 101 (51), pp. 17843-17848. , DOI 10.1073/pnas.0408154101Simões, G.F., Oliveira, A.L.R., Alpha motoneurone input changes in dystrophic MDX mice after sciatic nerve transaction Neuropathol Appl Neurobiol, 2010 (36), pp. 55-70Aldskogius, H., Liu, L., Svensson, M., Glial responses to synaptic damage and plasticity (1999) Journal of Neuroscience Research, 58 (1), pp. 33-41. , DOI 10.1002/(SICI)1097-4547(19991001)58:1<33::AID-JNR5>3.0.CO;2-MDerouiche, A., Frotscher, M., Peripheral astrocyte processes: Monitoring by selective immunostaining for the actin-binding ERM proteins (2001) GLIA, 36 (3), pp. 330-341. , DOI 10.1002/glia.1120Brannstrom, T., Kellerth, J.-O., Changes in synaptology of adult cat spinal α-motoneurons after axotomy (1998) Experimental Brain Research, 118 (1), pp. 1-13. , DOI 10.1007/s002210050249Cullheim, S., Thams, S., The microglial networks of the brain and their role in neuronal network plasticity after lesion (2007) Brain Research Reviews, 55 (1), pp. 89-96. , DOI 10.1016/j.brainresrev.2007.03.012, PII S0165017307000550Jarosinski, K.W., Massa, P.T., Interferon regulatory factor-1 is required for interferon-g-induced MHC class i genes in astrocytes (2002) J Neuroimmunol, 122 (1-2), pp. 74-84Keilhoff, G., Fansa, H., Wolf, G., Neuronal NOS deficiency promotes apoptotic cell death of spinal cord neurons after peripheral nerve transection (2004) Nitric Oxide - Biology and Chemistry, 10 (2), pp. 101-111. , DOI 10.1016/j.niox.2004.03.008, PII S1089860304000564He, J., Xiao, Y., Zhang, L., Cocaine-mediated apoptosis in bovine coronary artery endothelial cells: Role of nitric oxide (2001) Journal of Pharmacology and Experimental Therapeutics, 298 (1), pp. 180-187Emirandetti, A., Influência do MHC clásssico (Ia) e não-clássico (1b) e da óxido nítrico sintase indizível (iNOS) na reação glial e na plasticidade das sinapses após axotomia periférica [tese] (2009) Campinas (SP), , Universidade Estadual de CampinasEmirandetti, A., Graciele, Z.R., Sabha Jr., M., De Oliveira, A.L., Astrocyte reactivity influences the number of presynaptic terminals apposed to spinal motoneurons after axotomy (2006) Brain Research, 1095 (1), pp. 35-42. , DOI 10.1016/j.brainres.2006.04.021, PII S0006899306010444Thams, S., Oliveira, A., Cullheim, S., MHC class i expression and synaptic plasticity after nerve lesion (2008) Brain Research Reviews, 57 (1), pp. 265-269. , DOI 10.1016/j.brainresrev.2007.06.016, PII S0165017307001166, Networks in MotionMoran, L.B., Graeber, M.B., The facial nerve axotomy model (2004) Brain Res Rev., 44 (2-3), pp. 154-178Barron, K.D., (1983) Comparative Observations on the Cytologic Reactions of Central and Peripheral Nerve Cells to Axotomy., pp. 7-39. , Kao CC, Bunge RP, Reier PJ, editors. Spinal cord reconstruction. New York: Rave PressLindå, H., Piehl, F., Dagerlind, A., Verge, V.M., Arvidsson, U., Cullheim, S., Expression of GAP-43 mRNA in the adult mammalian spinal cord under normal conditions and after different types of lesions, with special reference to motoneurons (1992) Exp Brain Res., 91 (2), pp. 284-295Piehl, F., Arvidsson, U., Johnson, H., Cullheim, S., Dagerlind, A., Ulfhake, B., Cao, Y., Hokfelt, T., GAP-43, aFGF, CCK and α- And β-CGRP in rat spinal motoneurons subjected to axotomy and/or dorsal root severance (1993) European Journal of Neuroscience, 5 (10), pp. 1321-1333. , DOI 10.1111/j.1460-9568.1993.tb00918.xPiehl, F., Hammarberg, H., Hokfelt, T., Cullheim, S., Regulatory effects of trophic factors on expression and distribution of CGRP and GAP-43 in rat motoneurons (1998) Journal of Neuroscience Research, 51 (1), pp. 1-14. , DOI 10.1002/(SICI)1097-4547(19980101)51:1<1::AID-JNR1>3.0.CO;2-LZanon, R.G., Influência da modulação da expressão do MHC i sobre a astrogliose reativa e plasticidade sináptica [tese] (2009) Campinas (SP), , Universidade Estadual de CampinasMoreira, M.A., Felipe, E., Endes, M.F., Tilbery, C.P., Esclerose múltipla (2000) Arq Neuropsiquiat, 58 (2 B), pp. 460-466Co, B., Hh, R., As, F., Cytokines and intrathecal Igg synthesis in multiple sclerosis patiens during clinical remission (2005) Arq Neuropsiquiatr, 63 (4), pp. 914-919Newmann, H., Cavalie, A., Jenne De Wekerle, H., Induction of Mhc class i genes in neurons (1995) Science, 269 (5223), pp. 549-552Marques, K.B., Santos, L.M., Oliveira, A.L., Spinal motoneuron synaptic plasticity during the course of an animal model of multiple sclerosis (2006) Eur J Neurosci, 24 (11), pp. 3053-3062Freria, C.M., Zanon, R.G., Santos, L.M.B., Oliveira, A.L.R., MHC i expression and glial reaction influence spinal motoneuron synaptic plasticity during the course of experimental autoimmune encephalomyelitis J Comp Neurol, 2010. , acceptedSyken, J., Shatz, C.J., Expression of T cell receptor β locus in central nervous system neurons (2003) Proceedings of the National Academy of Sciences of the United States of America, 100 (22), pp. 13048-13053. , DOI 10.1073/pnas.1735415100Syken, J., GrandPre, T., Kanold, P.O., Shatz, C.J., PirB restricts ocular-dominance plasticity in visual cortex (2006) Science, 313 (5794), pp. 1795-1800. , DOI 10.1126/science.112823