Formaldehyde and cancer risk : a quantitative review of cohort studies through 2006

Background: Occupational exposure to formaldehyde has been associated with excess risk of nasopharyngeal and selected other cancers. Patientsand methods: We reviewed and pooled the results of cohort studies published through February 2007. Results: There were 5651 deaths from all cancers observed in six cohorts of industry workers and six of professionals, with a pooled relative risk (RR) of 0.95 for industry workers and of 0.87 for professionals. Nine deaths from nasopharyngeal cancer in three cohorts of industry workers yielded a pooled RR of 1.33, which declined to 0.49 after excluding six cases from one US plant. The pooled RR for lung cancer was 1.06 in industry workers and 0.63 in professionals. Corresponding values were 1.09 and 0.96 for oral and pharyngeal, 0.92 and 1.56 for brain, 0.85 and 1.31 for all lymphatic and hematopoietic cancers, and 0.90 and 1.39 for leukemia. Conclusions: Comprehensive review of cancer in industry workers and professionals exposed to formaldehyde shows no appreciable excess risk for oral and pharyngeal, sinonasal or lung cancers. A non-significantly increased RR for nasopharyngeal cancer among industry workers is attributable to a cluster of deaths in a single plant. For brain cancer and lymphohematopoietic neoplasms there were modestly elevated risks in professionals, but not industry workers

Authors' response: A further plea for adherence to the principles underlying science in general and the epidemiologic enterprise in particular

assent

Response: Re: False-positive results in cancer epidemiology : a plea for epistemological modesty

Référence FRBNF38491094 VDP8467 Intitulé Bibliothèque de France, anticipation Dates extrêmes 1992 Niveau de description Pièce Importance matérielle 19min Nom du producteur Bibliothèque nationale de France Réalisateur Madeleine Caillard Historique de la conservation Le fonds est conservé à la Bibliothèque nationale de France et au Forum des Images. Présentation du contenu A l'intérieur d'un gigantesque décor en images de synthèse représentant la future Bibliothèque de France (1..

A further plea for adherence to the principles underlying science in general and the epidemiologic enterprise in particular [Authors' response to comments]

Authors’ Response From JOSEPH K MCLAUGHLIN,1,2 LOREN LIPWORTH,1,2 ROBERT E TARONE,1,2 CARLO LA VECCHIA,3,4 WILLIAM J BLOT1,2 and PAOLO BOFFETTA

Monte Carlo theoretical trials of methods for assessing statistical significance for differences between adjusted odds ratios

Odds ratios, Logistic regression, Adjusted odds ratios, Differences in adjusted odds ratios, Monte Carlo trials,