The Coupling of Alternative Splicing and Nonsense-Mediated mRNA Decay

Most human genes exhibit alternative splicing, but not all alternatively spliced transcripts produce functional proteins. Computational and experimental results indicate that a substantial fraction of alternative splicing events in humans result in mRNA isoforms that harbor a premature termination codon (PTC). These transcripts are predicted to be degraded by the nonsense-mediated mRNA decay (NMD) pathway. One explanation for the abundance of PTC-containing isoforms is that they represent splicing errors that are identified and degraded by the NMD pathway. Another potential explanation for this startling observation is that cells may link alternative splicing and NMD to regulate the abundance of mRNA transcripts. This mechanism, which we call "Regulated Unproductive Splicing and Translation" (RUST), has been experimentally shown to regulate expression of a wide variety of genes in many organisms from yeast to human. It is frequently employed for autoregulation of proteins that affect the splicing process itself. Thus, alternative splicing and NMD act together to play an important role in regulating gene expression

The impact of union-sponsored boycotts on the stock prices of target firms

An empirical analysis of the impact of union-sponsored boycotts on the stock prices of target firms strongly suggests that union boycott announcements initially lead to economically and statistically significant losses in the stock prices of the target firms. However, this short-term price decline is almost completely erased by rebounds in stock prices over the ensuing 15 trading days. © 1988 Journal of Labor Research

Interpersonal relationship and lay third parties' side-taking preference: a cross-cultural study among Chinese and Dutch

In two comparative studies, both conducted in China and in the Netherlands, we investigated the effect of an asymmetric relationship on lay third parties’ side-taking preference in an interpersonal dispute. The first study shows that a perceived close relationship with one of the disputants motivates both Chinese and Dutch lay third parties to side with that disputant. The second study complicates the interpersonal relationship and side-taking link by taking account of contrasting information (either legitimacy or negative sanctions) about the other disputant and cultural dimensions (horizontal and vertical individualism-collectivism). The results suggest that contrasting legitimacy information has a decisive effect on lay third parties’ side-taking preference, especially among Dutch lay third parties who highly value vertical individualism. In addition to legitimacy criteria, Chinese lay third parties, whether individualistic or collectivistic oriented, seem to also consider interpersonal relationship and sanction information when making their side-taking decision