27 research outputs found

    Bio-analytical Assay Methods used in Therapeutic Drug Monitoring of Antiretroviral Drugs-A Review

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    New insights into the genetic etiology of Alzheimer's disease and related dementias

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    Characterization of the genetic landscape of Alzheimer's disease (AD) and related dementias (ADD) provides a unique opportunity for a better understanding of the associated pathophysiological processes. We performed a two-stage genome-wide association study totaling 111,326 clinically diagnosed/'proxy' AD cases and 677,663 controls. We found 75 risk loci, of which 42 were new at the time of analysis. Pathway enrichment analyses confirmed the involvement of amyloid/tau pathways and highlighted microglia implication. Gene prioritization in the new loci identified 31 genes that were suggestive of new genetically associated processes, including the tumor necrosis factor alpha pathway through the linear ubiquitin chain assembly complex. We also built a new genetic risk score associated with the risk of future AD/dementia or progression from mild cognitive impairment to AD/dementia. The improvement in prediction led to a 1.6- to 1.9-fold increase in AD risk from the lowest to the highest decile, in addition to effects of age and the APOE ε4 allele

    Boys and road rage: Driving related violence and aggression in Western Australia.

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    This article reports on the results of a population survey of 1208 West Australian drivers designed to measure the prevalence of drivingrelated violence and aggression as well as perceptions of these behaviours. A clear distinction is made between driving-related violence (restricted to criminal acts of violence, threats of violence and vehicle damage) and other aggressive driving behaviours. Although the majority of survey respondents had experienced some form of aggressive driving behaviour, only 13% reported ever being a victim of driving-related violence. However, 17% of respondents believed they were likely, or very likely, to be a victim of driving-related violence within the coming year. More than two thirds of respondents thought their likelihood of being a victim of driving-related violence had increased over the past 10 years. Both aggressive driving behaviours and driving-related violence were typically perpetrated by young males against other males. The article concludes with a discussion of the masculinist characteristics of road rage and what this implies for the prevention of this crime
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