Resolving the Outer Disks and Halos of Nearby Galaxies

In a hierarchical merging scenario, the outer parts of a galaxy are a fossil record of the galaxy's early history. Observations of the outer disks and halos of galaxies thus provide a tool to study individual galaxy histories and test formation theories. Locally, an impressive effort has been made to understand the halo of the Milky Way, Andromeda, and M33. However, due to the stochastic nature of halo formation, a better understanding of this process requires a large sample of galaxies with known halo properties. The GHOSTS project (PI: R. de Jong) aims to characterize the halos and outer portions of 14 nearby (D=4-14 Mpc) spiral galaxies using the Hubble Space Telescope. Detection of individual stars in the outer parts of these galaxies enables us to study both the morphological properties of the galaxies, and determine the stars' metallicity and age.Comment: Contributed talk; to appear in the proceedings of "Galaxies in the Local Volume" Sydney 8-13 July 200

Loop operators and S-duality from curves on Riemann surfaces

We study Wilson-'t Hooft loop operators in a class of N=2 superconformal field theories recently introduced by Gaiotto. In the case that the gauge group is a product of SU(2) groups, we classify all possible loop operators in terms of their electric and magnetic charges subject to the Dirac quantization condition. We then show that this precisely matches Dehn's classification of homotopy classes of non-self-intersecting curves on an associated Riemann surface--the same surface which characterizes the gauge theory. Our analysis provides an explicit prediction for the action of S-duality on loop operators in these theories which we check against the known duality transformation in several examples.Comment: 41 page

"Holey Sheets" - Pfaffians and Subdeterminants as D-brane Operators in Large N Gauge Theories

In the AdS/CFT correspondence, wrapped D3-branes (such as "giant gravitons") on the string theory side of the correspondence have been identified with Pfaffian, determinant and subdeterminant operators on the field theory side. We substantiate this identification by showing that the presence of pairs of such operators in a correlation function of a large N gauge theory naturally leads to a modified 't Hooft expansion including also worldsheets with boundaries. This happens independently of supersymmetry or conformal invariance.Comment: 39 pages, 10 figures, harvma

Exact-exchange density-functional calculations for noble-gas solids

The electronic structure of noble-gas solids is calculated within density functional theory's exact-exchange method (EXX) and compared with the results from the local-density approximation (LDA). It is shown that the EXX method does not reproduce the fundamental energy gaps as well as has been reported for semiconductors. However, the EXX-Kohn-Sham energy gaps for these materials reproduce about 80 % of the experimental optical gaps. The structural properties of noble-gas solids are described by the EXX method as poorly as by the LDA one. This is due to missing Van der Waals interactions in both, LDA and EXX functionals.Comment: 4 Fig

N=1* in 5 dimensions: Dijkgraaf-Vafa meets Polchinski-Strassler

One of the powerful techniques to analyze the 5 dimensional Super Yang Mills theory with a massive hypermultiplet (N=1*) is provided by the AdS/CFT correspondence. It predicts that, for certain special values of the hypermultiplet mass, this theory develops nonperturbative branches of the moduli space as well as new light degrees of freedom. We use the higher dimensional generalization of the matrix model/gauge theory correspondence and recover all the prediction of the supergravity analysis. We construct the map between the four dimensional holomorphic superpotential and the five dimensional action and explicitly show that the superpotential is flat along the nonperturbative branches. This is the first instance in which the Dijkgraaf-Vafa method is used to analyze intrinsically higher dimensional phenomena.Comment: 28 pages, Late

Endemic fungal infections in solid organ and hematopoietic cell transplant recipients enrolled in the Transplant‐Associated Infection Surveillance Network ( TRANSNET )

Background Invasive fungal infections are a major cause of morbidity and mortality among solid organ transplant ( SOT ) and hematopoietic cell transplant ( HCT ) recipients, but few data have been reported on the epidemiology of endemic fungal infections in these populations. Methods Fifteen institutions belonging to the Transplant‐Associated Infection Surveillance Network prospectively enrolled SOT and HCT recipients with histoplasmosis, blastomycosis, or coccidioidomycosis occurring between March 2001 and March 2006. Results A total of 70 patients (64 SOT recipients and 6 HCT recipients) had infection with an endemic mycosis, including 52 with histoplasmosis, 9 with blastomycosis, and 9 with coccidioidomycosis. The 12‐month cumulative incidence rate among SOT recipients for histoplasmosis was 0.102%. Occurrence of infection was bimodal; 28 (40%) infections occurred in the first 6 months post transplantation, and 24 (34%) occurred between 2 and 11 years post transplantation. Three patients were documented to have acquired infection from the donor organ. Seven SOT recipients with histoplasmosis and 3 with coccidioidomycosis died (16%); no HCT recipient died. Conclusions This 5‐year multicenter prospective surveillance study found that endemic mycoses occur uncommonly in SOT and HCT recipients, and that the period at risk extends for years after transplantation.Peer Reviewedhttp://deepblue.lib.umich.edu/bitstream/2027.42/106980/1/tid12186.pd

Reuse of cell culture inserts for in vitro human primary airway epithelial cell studies

To the Editor: Humanprimary bronchial epithelial (HBE) cells have a long history in respiratory research. With the establishment of protocols for expansion of primary airway epithelial cells with conditionally reprogrammed cell methods (1, 2), cellular redifferentiation using air–liquid interface (ALI) conditions on porous membranes, and lentiviral infection and CRISPR/Cas9-mediated transduction and gene knockdown technologies (3, 4), the use of HBE cell cultures for respiratory research has greatly expanded

A Genome-wide Association Study Discovers 46 Loci of the Human Metabolome in the Hispanic Community Health Study/Study of Latinos

Variation in levels of the human metabolome reflect changes in homeostasis, providing a window into health and disease. The genetic impact on circulating metabolites in Hispanics, a population with high cardiometabolic disease burden, is largely unknown. We conducted genome-wide association analyses on 640 circulating metabolites in 3,926 Hispanic Community Health Study/Study of Latinos participants. The estimated heritability for 640 metabolites ranged between 0%–54% with a median at 2.5%. We discovered 46 variant-metabolite pairs (p value < 1.2 × 10−10, minor allele frequency ≥ 1%, proportion of variance explained [PEV] mean = 3.4%, PEVrange = 1%–22%) with generalized effects in two population-based studies and confirmed 301 known locus-metabolite associations. Half of the identified variants with generalized effect were located in genes, including five nonsynonymous variants. We identified co-localization with the expression quantitative trait loci at 105 discovered and 151 known loci-metabolites sets. rs5855544, upstream of SLC51A, was associated with higher levels of three steroid sulfates and co-localized with expression levels of SLC51A in several tissues. Mendelian randomization (MR) analysis identified several metabolites associated with coronary heart disease (CHD) and type 2 diabetes. For example, two variants located in or near CYP4F2 (rs2108622 and rs79400241, respectively), involved in vitamin E metabolism, were associated with the levels of octadecanedioate and vitamin E metabolites (gamma-CEHC and gamma-CEHC glucuronide); MR analysis showed that genetically high levels of these metabolites were associated with lower odds of CHD. Our findings document the genetic architecture of circulating metabolites in an underrepresented Hispanic/Latino community, shedding light on disease etiology

Typicality, Black Hole Microstates and Superconformal Field Theories

We analyze the structure of heavy multitrace BPS operators in N = 1 superconformal quiver gauge theories that arise on the worldvolume of D3-branes on an affine toric cone. We exhibit a geometric procedure for counting heavy mesonic operators with given U(1) charges. We show that for any fixed linear combination of the U(1) charges, the entropy is maximized when the charges are in certain ratios. This selects preferred directions in the charge space that can be determined with the help of a piece of string. We show that almost all heavy mesonic operators of fixed U(1) charges share a universal structure. This universality reflects the properties of the dual extremal black holes whose microstates they create. We also interpret our results in terms of typical configurations of dual giant gravitons in AdS space.Comment: 40 pages + 3 appendices, 11 figure