Fermion Chern Simons Theory of Hierarchical Fractional Quantum Hall States

We present an effective Chern-Simons theory for the bulk fully polarized fractional quantum Hall (FQH) hierarchical states constructed as daughters of general states of the Jain series, {\it i. e.} as FQH states of the quasi-particles or quasi-holes of Jain states. We discuss the stability of these new states and present two reasonable stability criteria. We discuss the theory of their edge states which follows naturally from this bulk theory. We construct the operators that create elementary excitations, and discuss the scaling behavior of the tunneling conductance in different situations. Under the assumption that the edge states of these fully polarized hierarchical states are unreconstructed and unresolved, we find that the differential conductance $G$ for tunneling of electrons from a Fermi liquid into {\em any} hierarchical Jain FQH states has the scaling behavior $G\sim V^\alpha$ with the universal exponent $\alpha=1/\nu$, where $\nu$ is the filling fraction of the hierarchical state. Finally, we explore alternative ways of constructing FQH states with the same filling fractions as partially polarized states, and conclude that this is not possible within our approach.Comment: 10 pages, 50 references, no figures; formerly known as "Composite Fermions: The Next Generation(s)" (title changed by the PRB thought police). This version has more references and a discussion of the stability of the new states. Published version. One erroneous reference is correcte

Fractional Quantum Hall States of Clustered Composite Fermions

The energy spectra and wavefunctions of up to 14 interacting quasielectrons (QE's) in the Laughlin nu=1/3 fractional quantum Hall (FQH) state are investigated using exact numerical diagonalization. It is shown that at sufficiently high density the QE's form pairs or larger clusters. This behavior, opposite to Laughlin correlations, invalidates the (sometimes invoked) reapplication of the composite fermion picture to the individual QE's. The series of finite-size incompressible ground states are identified at the QE filling factors nu_QE=1/2, 1/3, 2/3, corresponding to the electron fillings nu=3/8, 4/11, 5/13. The equivalent quasihole (QH) states occur at nu_QH=1/4, 1/5, 2/7, corresponding to nu=3/10, 4/13, 5/17. All these six novel FQH states were recently discovered experimentally. Detailed analysis indicates that QE or QH correlations in these states are different from those of well-known FQH electron states (e.g., Laughlin or Moore-Read states), leaving the origin of their incompressibility uncertain. Halperin's idea of Laughlin states of QP pairs is also explored, but is does not seem adequate.Comment: 14 pages, 9 figures; revision: 1 new figure, some new references, some new data, title chang

Editor's Choice - Infective Native Aortic Aneurysms: A Delphi Consensus Document on Terminology, Definition, Classification, Diagnosis, and Reporting Standards.

There is no consensus regarding the terminology, definition, classification, diagnostic criteria, and algorithm, or reporting standards for the disease of infective native aortic aneurysm (INAA), previously known as mycotic aneurysm. The aim of this study was to establish this by performing a consensus study. The Delphi methodology was used. Thirty-seven international experts were invited via mail to participate. Four two week Delphi rounds were performed, using an online questionnaire, initially with 22 statements and nine reporting items. The panellists rated the statements on a five point Likert scale. Comments on statements were analysed, statements revised, and results presented in iterative rounds. Consensus was defined as ≥ 75% of the panel selecting "strongly agree" or "agree" on the Likert scale, and consensus on the final assessment was defined as Cronbach's alpha coefficient > .80. All 38 panellists completed all four rounds, resulting in 100% participation and agreement that this study was necessary, and the term INAA was agreed to be optimal. Three more statements were added based on the results and comments of the panel, resulting in a final 25 statements and nine reporting items. All 25 statements reached an agreement of ≥ 87%, and all nine reporting items reached an agreement of 100%. The Cronbach's alpha increased for each consecutive round (round 1 = .84, round 2 = .87, round 3 = .90, and round 4 = .92). Thus, consensus was reached for all statements and reporting items. This Delphi study established the first consensus document on INAA regarding terminology, definition, classification, diagnostic criteria, and algorithm, as well as reporting standards. The results of this study create essential conditions for scientific research on this disease. The presented consensus will need future amendments in accordance with newly acquired knowledge

CHIRAL BACKGROUND FOR THE TWO PION EXCHANGE NUCLEAR POTENTIAL: A PARAMETRIZED VERSION

We argue that the minimal chiral background for the two-pion exchange nucleon-nucleon interaction has nowadays a rather firm conceptual basis, which entitles it to become a standard ingredient of any modern potential. In order to facilitate applications, we present a parametrized version of a configuration space potential derived previously. We then use it to assess the phenomenological contents of some existing NN potentials.Comment: REVTEX style, 16 pages, 5 PostScript figures compressed, tarred and uuencode

Proteogenomic landscape of breast cancer tumorigenesis and targeted therapy

The integration of mass spectrometry-based proteomics with next-generation DNA and RNA sequencing profiles tumors more comprehensively. Here this "proteogenomics" approach was applied to 122 treatment-naive primary breast cancers accrued to preserve post-translational modifications, including protein phosphorylation and acetylation. Proteogenomics challenged standard breast cancer diagnoses, provided detailed analysis of the ERBB2 amplicon, defined tumor subsets that could benefit from immune checkpoint therapy, and allowed more accurate assessment of Rb status for prediction of CDK4/6 inhibitor responsiveness. Phosphoproteomics profiles uncovered novel associations between tumor suppressor loss and targetable kinases. Acetylproteome analysis highlighted acetylation on key nuclear proteins involved in the DNA damage response and revealed cross-talk between cytoplasmic and mitochondrial acetylation and metabolism. Our results underscore the potential of proteogenomics for clinical investigation of breast cancer through more accurate annotation of targetable pathways and biological features of this remarkably heterogeneous malignancy

The Water Quality of Several Oxbow Lakes in Sabah, Malaysia and its Relation to Fish Fauna Distribution

A record of the water quality and fish fauna composition of the Luagan Rompong oxbow lake of the Padas River near Beaufort, the Kalandaun and Kalananap oxbow lakes of the Kinabatangan River at Sukau is presented in this study. The water quality of all three oxbow lakes exhibited wide daily variation in dissolved oxygen content (3.9-12.4 mg L-1) and also large changes in daily water, especially for the Kinabatangan oxbow lakes. All three lakes demonstrated different composition of fish fauna with the Cyprinidae famili (45-80%) dominating in the lakes. The Shannon-Weiner diversity indices for fish from all the lakes were between 2.15 and 3.13 with the Kalandaun Lake at the Kinabatangan River showed highest fish fauna diversit

Preserving new anthelmintics: a simple method for estimating faecal egg count reduction test (FECRT) confidence limits when efficacy and/or nematode aggregation is high.

As it has been 30 years since a new anthelmintic class was released, it is appropriate to review management practices aimed at slowing the development of anthelmintic resistance to all drug classes. Recommendations to delay anthelmintic resistance and provide “refugia” are reviewed and a simulation model used to find optimum treatment strategies that maintain nematode control. Simulated Australian conditions indicated that a common successful low-risk treatment program was a rapid rotation between a “triple-combination” product (benzimidazole + levamisole + abamectin) and a new high-efficacy drug (monepantel). Where Haemonchus contortus was a threat, moxidectin was required at critical times because of its persistent activity against this parasite. Leaving up to 4% of adult sheep untreated provided sufficient “refugia” for non-selected worms to reduce the risk of selecting for anthelmintic resistance without compromising nematode control. For a new anthelmintic, efficacy estimated by faecal egg count reduction (FECR) is likely to be at or close to 100%, however using current methods the 95% confidence limits (CL) for 100% are incorrectly determined as 100%. The fewer eggs counted pre-treatment, the more likely an estimate of 100% will occur, particularly if the true efficacy is >90%. A novel way to determine the lower-CL (LCL) for 100% efficacy is to reframe FECR as a binomial proportion, i.e. define: n and x as the total number of eggs counted (rather than eggs per gram of faeces) for all pre-treatment and post-treatment animals, respectively; p the proportion of resistant eggs is p = x/n and percent efficacy is 100*(1-p) (assuming equal treatment group sizes and detection levels, pre- and post-treatment). The LCL is approximated from the cumulative inverse beta distribution by: 95%LCL = 100*(1-(BETAINV(0.975,x + 1,n-x + 1))). This method is simpler than the current method, independent of the number of animals tested, and demonstrates that for 100% efficacy at least 37 eggs (not eggs per gram) need to be counted pre-treatment before the LCL can exceed 90%. When nematode aggregation is high, this method can be usefully applied to efficacy estimates lower than 100%, and in this case the 95% upper-CL (UCL) can be estimated by: 95%UCL = 100*(1-(BETAINV(0.025,x + 1,n-x + 1))), with the LCL approximated as described above. A simulation study to estimate the precision and accuracy of this method found that the more conservative 99%CL was optimum; in this case 0.975 and 0.025 are replaced by 0.995 and 0.005 to estimate the LCL and UCL, respectively