Thomson Scattering of Coherent Diffraction Radiation by an Electron Bunch

The paper considers the process of Thomson scattering of coherent diffraction radiation (CDR) produced by the preceding bunch of the accelerator on one of the following bunches. It is shown that the yield of scattered hard photons is proportional to N$_e^3$, where N$_e$ is the number of electrons per bunch. A geometry is chosen for the CDR generation and an expression is obtained for the scattered photon spectrum with regard to the geometry used, that depends in an explicit form on the bunch size. A technique is proposed for measuring the bunch length using scattered radiation characteristics.Comment: 14 pages, LATEX, 6 ps.gz figures, submitted to Phys.Rev.

Combined FDG-PET/CT for the detection of unknown primary tumors: systematic review and meta-analysis

The aim of this study was to systematically review and meta-analyze published data on the diagnostic performance of combined 18F-fluoro-2-deoxyglucose positron emission tomography/computed tomography (FDG-PET/CT) in the detection of primary tumors in patients with cancer of unknown primary (CUP). A systematic search for relevant studies was performed of the PubMed/MEDLINE and Embase databases. Methodological quality of the included studies was assessed. Reported detection rates, sensitivities and specificities were meta-analyzed. Subgroup analyses were performed if results of individual studies were heterogeneous. The 11 included studies, comprising a total sample size of 433 patients with CUP, had moderate methodological quality. Overall primary tumor detection rate, pooled sensitivity and specificity of FDG-PET/CT were 37%, 84% (95% CI 78–88%) and 84% (95% CI 78–89%), respectively. Sensitivity was heterogeneous across studies (P = 0.0001), whereas specificity was homogeneous across studies (P = 0.2114). Completeness of diagnostic workup before FDG-PET/CT, location of metastases of unknown primary, administration of CT contrast agents, type of FDG-PET/CT images evaluated and way of FDG-PET/CT review did not significantly influence diagnostic performance. In conclusion, FDG-PET/CT can be a useful method for unknown primary tumor detection. Future studies are required to prove the assumed advantage of FDG-PET/CT over FDG-PET alone and to further explore causes of heterogeneity

FDG PET/CT in carcinoma of unknown primary

Carcinoma of unknown primary (CUP) is a heterogeneous group of metastatic malignancies in which a primary tumor could not be detected despite thorough diagnostic evaluation. Because of its high sensitivity for the detection of lesions, combined 18F-fluoro-2-deoxyglucose positron emission tomography (FDG PET)/computed tomography (CT) may be an excellent alternative to CT alone and conventional magnetic resonance imaging in detecting the unknown primary tumor. This article will review the use, diagnostic performance, and utility of FDG PET/CT in CUP and will discuss challenges and future considerations in the diagnostic management of CUP

Diagnosis and localization of renal cyst infection by 18F-fluorodeoxyglucose PET/CT in polycystic kidney disease

Renal cyst infection in polycystic kidney disease is a serious complication. Early diagnosis and localization of infected cyst are crucial and usually require conventional imaging modalities, including ultrasound and computed tomography (CT). However, their contribution is limited because of nonspecific results. We report on a patient with suspected renal cyst infection for which 18F-fluorodeoxyglucose positron emission tomography (FDG-PET)/CT scan allowed the exact localization of the infected cyst and guided a drainage procedure. FDG-PET/CT imaging could be a valuable tool for early identification of infected renal cyst infection, and may contribute to better patient management

Experimental investigations on geometrical resolution of optical transition radiation (otr)

Optical Transition Radiation (OTR) provides an attractive method for diagnostics on electron/positron beams of small dimensions at high energies (GeV). However, some limits on the geometrical resolution at very high energies have been often discussed in the literature and a minimum value given by 'cj' has been invoked. In order to bring an experimental contribution to the problem, systematic measurements of electron beam profiles, in the energy range of 1—2 GeV and at optical wavelength between 400 and 700 nm, have been carried out at the Orsay 2 GeV Linear Accelerator. OTR emitted from an aluminium foil at a 30i incidence angle was collected by a two-lens telescope and recorded by an intensified CCD camera. The OTR beam profiles were compared to the profiles obtained by a SEM Grid having a resolution better than 0.5 mm. After a theoretical introduction presenting the di⁄erent resolution limits, which can be invoked with di⁄raction phenomenon, and a presentation of our calibration procedure, the experimental results are presented and compared to these limits. They show that the resolution in OTR measurements is definitely better than the already invoked cj-limit. For a small size electron beam an r.m.s. beam width about 170 lm has been determined. This value can be compared to cj"2.5 mm (E"2 GeV and j"650 nm). Our theoretical analysis also provides a more precise evaluation of the resolution power of OTR, which depends on the sensitivity of the detector; this could be of interest for much higher energies. ( 1998 Elsevier Science B.V. All rights reserved