23 research outputs found
Mesothelin versus Ca125 in Screening the Ovarian Malignancy
Objective: To determine the sensitivity and specificity of mesothelin
compared with Ca-125 as a tumor marker in predicting ovarian malignancy.
Method: The cross sectional study design with diagnostic tests was
conducted in 30 samples of patients undergoing elective laparotomy
due to ovarian tumor. We compared the sensitivity and specificity
between mesothelin and Ca-125, then the data were analyzed using
SPSS software version 22.0.
Result: According to the ROC curve analysis, optimal sensitivity and
specificity value of mesothelin was 63.2% and 54.5% at a cut-off
point of 0.45 pg/ml; or 42.1% and 72.7% at a cut-off point of 0.55
pg/ml. While the value of both optimal sensitivity and specificity of
Ca-125 was 73.7% and 63.6% at a cut-off point of 46.63 U/ml.
Conclusion: Mesothelin and Ca-125 are not different significantly
for the AUC value of 50%. Due to higher sensitivity and specificity of
Ca-125 than mesothelin, Ca-125 is still used as tumor marker for
screening the ovarian malignancy.
[Indones J Obstet Gynecol 2016; 4-2: 107-110]
Keywords: Ca-125, mesothelin, ovarian malignanc
Stem cell culture conditions and stability: a joint workshop of the PluriMes Consortium and Pluripotent Stem Cell Platform
Human stem cells have the potential to transform medicine. However, hurdles remain to ensure that manufacturing processes produce safe and effective products. A thorough understanding of the biological processes occurring during manufacture of what can be very complex products, is fundamental to assuring these qualities and thus, their acceptability to regulators and clinicians. Leaders in both human pluripotent and somatic stem cells, were brought together with experts in clinical translation, bio-manufacturing and regulation, to discuss key issues in assuring appropriate manufacturing conditions for delivery of effective and safe products from these cell types. This report summarizes the key issues discussed and records consensus reached by delegates and emphasizes the need for accurate language and nomenclature in the scientific discourse around stem cells