Incidence of urinary retention during treatment with single tablet combinations of solifenacin+tamsulosin OCAS™ for up to 1 year in adult men with both storage and voiding LUTS: a subanalysis of the NEPTUNE/NEPTUNE II randomized controlled studies

Introduction: The emergence of urinary retention (UR), specifically acute urinary retention (AUR), has been a concern when treating men with lower urinary tract symptoms (LUTS) with antimuscarinic drugs. Materials and methods: In NEPTUNE (12-week, double-blind), men (≥45 years) with LUTS were randomized to receive tamsulosin oral-controlled absorption system (TOCAS) 0.4 mg, fixed-dose combination (FDC) of solifenacin (Soli) 6 mg + TOCAS 0.4 mg, FDC Soli 9 mg + TOCAS 0.4 mg, or placebo. In NEPTUNE II (40-week, open-label extension of NEPTUNE), continuing patients received 4-week FDC Soli 6 mg + TOCAS, then FDC Soli 6 mg or 9 mg + TOCAS for the remainder of the study, switchable every 3 months. Results: Across both studies, 1208 men received ≥1 dose of FDC Soli 6 mg or 9 mg + TOCAS for up to 52 weeks; 1199 men completed NEPTUNE and 1066 received ≥1 dose in NEPTUNE II. In total, 13 men (1.1%; 95% CI, 0.6%-1.8%) reported a UR event while receiving FDC, eight of which were AUR (0.7%; 95% CI, 0.3%-1.3%, incidence 7/1000 man-years). Six men reported UR events while taking Soli 6 mg + TOCAS (three AUR), and seven men reported a UR event while taking Soli 9 mg + TOCAS (five AUR). One man developed AUR while taking TOCAS alone and four reported UR (three AUR) during placebo run-in. Most AUR/ UR events occurred within 4 months of treatment initiation. Conclusions: FDC Soli and TOCAS was associated with a low rate of UR and AUR in men with LUTS

Writing : A Versatile Resource in the Treatment of the Clients’ Proposals

This chapter investigates how writing serves as a resource in decision-making at the Clubhouse and how writing activities relate to professionals’ responses to clients. The ideology of the Clubhouse is one of interaction, and in accordance with this perspective, support workers and clients should be treated equally in decision-making processes related to the activity of the Clubhouse. However, as demonstrated in previous research, encouraging clients in mental health rehabilitation to participate actively in interaction and decision-making can be difficult. Therefore, support workers carry a substantial responsibility for promoting clients’ participation in interactions; this responsibility is supported by how they respond to clients. The focus in this chapter is on a certain type of participation-encouraging response—that is, a response that promotes the documentation of vaguely expressed ideas in written documents and encourages a dialogue between support workers and Clubhouse clients around the formulations in a text-in-production.This chapter investigates how writing serves as a resource in decision-making at the Clubhouse and how writing activities relate to professionals’ responses to clients. The ideology of the Clubhouse is one of interaction, and in accordance with this perspective, support workers and clients should be treated equally in decision-making processes related to the activity of the Clubhouse. However, as demonstrated in previous research, encouraging clients in mental health rehabilitation to participate actively in interaction and decision-making can be difficult. Therefore, support workers carry a substantial responsibility for promoting clients’ participation in interactions; this responsibility is supported by how they respond to clients. The focus in this chapter is on a certain type of participation-encouraging response—that is, a response that promotes the documentation of vaguely expressed ideas in written documents and encourages a dialogue between support workers and Clubhouse clients around the formulations in a text-in-production.Peer reviewe

Schrijven, hyven, facebooken, rappen en tweeten over criminaliteit. Een talige verkenning van de leefwereld, normen en warden van Nederlandse jongeren.

In December 2007, Goldman Sachs launched a product called QxX index swap, which is designed to allow market participants to hedge or gain exposure to longevity and mortality risks. In this paper, we offer a quantitative analysis of this brand new financial innovation. First of all, we set up a risk-neutral framework to price QxX index swaps. This framework, which is based on the dynamics of death rates under a two-factor stochastic mortality model in a risk-adjusted probability measure, yields prices (spreads) that are fairly close to the spreads that Goldman Sachs currently offers. We then explore the uncertainty involved in this model-based pricing framework. Specifically, we study parameter risk by using Bayesian methods and model risk by examining structural changes in mortality dynamics. Our results indicate that both model risk and parameter risk are significant. Actuaries should therefore be aware of these issues when placing a value on a longevity index swap. © 2013 Copyright Taylor and Francis Group, LLC

Sequence and secondary structure of the colicin fragment of Bacillus stearothermophilus 16S ribosomal RNA.

The sequence and the position of post-transcriptionally modified residues of the 3' -terminal end of Bacillus stearothermophilus 16S ribosomal RNA have been determined from the fragment that is cleaved off by bacteriocin treatment. The fragment contains 52 nucleotides, as compared to the 49 nucleotides of the corresponding fragment from E. coli ribosomes, The additional nucleotides are present in the sequence UCU very next to the 3' -terminus as was published earlier (1). The remainder of the sequence is identical to the one of E. coli except at six positions, due to the UV melting properties of the colicin fragment from B. stearothermophilus in comparison to the same fragment of E. coli show that the RNA from the thermophile has a more stable secondary structure

Adenosine dimethylation of 16S ribosomal RNA: effect of the methylgroups on local conformational stability as deduced from electrophoretic mobility of RNA fragments in denaturing polyacrylamide gels.

The electrophoretic mobility of RNA fragments derived from the 3'-end of 16S rRNA on slabs of polyacrylamide gel in the presence of urea is strongly influenced by dimethylation of the N6-aminogroup of two adjacent adenosines. This is not due to the presence of the methylgroups per se, but must be ascribed to an effect of methylation on long range intramolecular interactions at these denaturing conditions. When it is assumed that the electrophoretic mobilities of the RNA fragments in the polyacrylamide matrix are determined by the conformational state(s) of the fragments, dimethylation of the adenosines leads in the smaller fragments to a less compact average conformation and in the larger fragments to a more compact average conformation. An effort is made to comprehend the effects of adenosine dimethylation in terms of secondary structure based on nucleotide sequence