Genetic sensitivity to the bitter taste of 6-n-propylthiouracil (PROP) and its association with Physiological mechanisms controlling Body Mass Index (BMI)

Taste sensitivity to the bitter compound 6-n-propylthiouracil (PROP) is considered a marker for individual differences in taste perception that may influence food preferences and eating behavior, and thereby energy metabolism. This review describes genetic factors that may contribute to PROP sensitivity including: (1) the variants of the TAS2R38 bitter receptor with their different affinities for the stimulus; (2) the gene that controls the gustin protein that acts as a salivary trophic factor for fungiform taste papillae; and (3) other specific salivary proteins that could be involved in facilitating the binding of the PROP molecule with its receptor. In addition, we speculate on the influence of taste sensitivity on energy metabolism, possibly via modulation of the endocannabinoid system, and its possible role in regulating body composition homeostasis

The role of moisture in summertime low-level jet formation and associated rainfall over the East Asian monsoon region

The southwesterly low-level jet (LLJ) located to the east of the Tibetan Plateau in southern China plays an important role in summertime convective initiation over north China. This study adopts a novel perspective and uses hindcast experiments in order to investigate the role of moisture in LLJ and associated heavy rainfall formation, employing a global atmospheric general circulation model (AGCM). In the sensitivity experiments, an increase of humidity in the inflow region leads to a weaker LLJ but stronger diurnal wind oscillations. The weaker LLJ is due to a decreased lower-tropospheric east–west pressure gradient resulting from a low pressure anomaly over southeastern China induced by deep convection and related condensational heating. On the other hand, the stronger diurnal variation of the LLJ originates from stronger day-and-night thermal differences over the sloping terrain, which is related to drier conditions over the mountain range. Moreover, the increased humidity and decreased LLJ counteract one another to impact precipitation in the outflow region. The change of precipitation is mainly determined by the altered moisture flux divergence. If the increase in humidity dominates, then the moisture flux convergence is enhanced and favors more precipitation over north China. Otherwise, if the decreased LLJ dominates, then the moisture flux convergence is reduced, which constrains precipitation. It is highlighted that the moist diabatic and dynamic processes are intimately coupled, and that a correct simulation of moisture flux convergence is vital for AGCMs to reproduce the LLJ-related precipitation, particularly the nocturnal precipitation peak, which is a deficiency in many current models

Bott–Chern Laplacian on almost Hermitian manifolds

Let (M, J, g, ω) be a 2n-dimensional almost Hermitian manifold. We extend the definition of the Bott–Chern Laplacian on (M, J, g, ω) , proving that it is still elliptic. On a compact Kähler manifold, the kernels of the Dolbeault Laplacian and of the Bott–Chern Laplacian coincide. We show that such a property does not hold when (M, J, g, ω) is a compact almost Kähler manifold, providing an explicit almost Kähler structure on the Kodaira–Thurston manifold. Furthermore, if (M, J, g, ω) is a connected compact almost Hermitian 4-manifold, denoting by hBC1,1 the dimension of the space of Bott–Chern harmonic (1, 1)-forms, we prove that either hBC1,1=b- or hBC1,1=b-+1. In particular, if g is almost Kähler, then hBC1,1=b-+1, extending the result by Holt and Zhang (Harmonic forms on the Kodaira–Thurston manifold. arXiv:2001.10962, 2020) for the kernel of Dolbeault Laplacian. We also show that the dimensions of the spaces of Bott–Chern and Dolbeault harmonic (1, 1)-forms behave differently on almost complex 4-manifolds endowed with strictly locally conformally almost Kähler metrics. Finally, we relate some spaces of Bott-Chern harmonic forms to the Bott–Chern cohomology groups for almost complex manifolds, recently introduced in Coelho et al. (Maximally non-integrable almost complex structures: an h-principle and cohomological properties, arXiv:2105.12113, 2021)

On the Anti-invariant Cohomology of Almost Complex Manifolds

We study the space of closed anti-invariant forms on an almost complex manifold, possibly non-compact. We construct families of (non-integrable) almost complex structures on R4, such that the space of closed J-anti-invariant forms is infinite dimensional, and also 0- or 1-dimensional. In the compact case, we construct 6-dimensional almost complex manifolds with arbitrary large anti-invariant cohomology and a 2-parameter family of almost complex structures on the Kodaira–Thurston manifold whose anti-invariant cohomology group has maximum dimension

Mammalian models of extended healthy lifespan

Over the last two centuries, there has been a significant increase in average lifespan expectancy in the developed world. One unambiguous clinical implication of getting older is the risk of experiencing age-related diseases including various cancers, dementia, type-2 diabetes, cataracts and osteoporosis. Historically, the ageing process and its consequences were thought to be intractable. However, over the last two decades or so, a wealth of empirical data has been generated which demonstrates that longevity in model organisms can be extended through the manipulation of individual genes. In particular, many pathological conditions associated with the ageing process in model organisms, and importantly conserved from nematodes to humans, are attenuated in long-lived genetic mutants. For example, several long-lived genetic mouse models show attenuation in age-related cognitive decline, adiposity, cancer and glucose intolerance. Therefore, these long-lived mice enjoy a longer period without suffering the various sequelae of ageing. The greatest challenge in the biology of ageing is to now identify the mechanisms underlying increased healthy lifespan in these model organisms. Given that the elderly are making up an increasingly greater proportion of society, this focused approach in model organisms should help identify tractable interventions that can ultimately be translated to humans

Application of novel techniques for interferogram analysis to laser-plasma femtosecond probing

Recently, two novel techniques for the extraction of the phase-shift map (Tomassini {\it et.~al.}, Applied Optics {\bf 40} 35 (2001)) and the electronic density map estimation (Tomassini P. and Giulietti A., Optics Communication {\bf 199}, pp 143-148 (2001)) have been proposed. In this paper we apply both methods to a sample laser-plasma interferogram obtained with femtoseconds probe pulse, in an experimental setup devoted to laser particle acceleration studies.Comment: Submitted to Laser and Particle Beam

Social Dilemmas and Cooperation in Complex Networks

In this paper we extend the investigation of cooperation in some classical evolutionary games on populations were the network of interactions among individuals is of the scale-free type. We show that the update rule, the payoff computation and, to some extent the timing of the operations, have a marked influence on the transient dynamics and on the amount of cooperation that can be established at equilibrium. We also study the dynamical behavior of the populations and their evolutionary stability.Comment: 12 pages, 7 figures. to appea

Evolution of Cooperation and Coordination in a Dynamically Networked Society

Situations of conflict giving rise to social dilemmas are widespread in society and game theory is one major way in which they can be investigated. Starting from the observation that individuals in society interact through networks of acquaintances, we model the co-evolution of the agents' strategies and of the social network itself using two prototypical games, the Prisoner's Dilemma and the Stag Hunt. Allowing agents to dismiss ties and establish new ones, we find that cooperation and coordination can be achieved through the self-organization of the social network, a result that is non-trivial, especially in the Prisoner's Dilemma case. The evolution and stability of cooperation implies the condensation of agents exploiting particular game strategies into strong and stable clusters which are more densely connected, even in the more difficult case of the Prisoner's Dilemma.Comment: 18 pages, 14 figures. to appea

Optimization of 2-d lattice cellular automata for pseudorandom number generation

This paper proposes a generalized approach to 2-d CA PRNGs – the 2-d lattice CA PRNG – by introducing vertical connections to arrays of 1-d CA. The structure of a 2-d lattice CA PRNG lies in between that of 1-d CA and 2-d CA grid PRNGs. With the generalized approach, 2-d lattice CA PRNG offers more 2-d CA PRNG variations. It is found that they can do better than the conventional 2-d CA grid PRNGs. In this paper, the structure and properties of 2-d lattice CA are explored by varying the number and location of vertical connections, and by searching for different 2-d array settings that can give good randomness based on Diehard test. To get the most out of 2-d lattice CA PRNGs, genetic algorithm is employed in searching for good neighborhood characteristics. By adopting an evolutionary approach, the randomness quality of 2-d lattice CA PRNGs is optimized. In this paper, a new metric, #rn is introduced as a way of finding a 2-d lattice CA PRNG with the least number of cells required to pass Diehard test. Following the introduction of the new metric #rn, a cropping technique is presented to further boost the CA PRNG performance. The cost and efficiency of 2-d lattice CA PRNG is compared with past works on CA PRNGs

Primer registro de Scelidotheriinae Ameghino (Xenartha, Mylodontidae) del Piso/Edad Chasiquense (Mioceno tardío) de la Argentina

he subfamily Scelidotheriinae constitutes a group of mylodontids widely represented in the Quaternary of South America; however, the fossil record of the Neogene taxa is still scarce. In the present paper, a new specimen of this subfamily, corresponding to a right partial hemimandible with complete dental series, is reported. The material was recovered from the lower levels of the Arenisca Albardón Member of the Loma de Las Tapias Formation (San Juan Province, Argentina), assigned to the late Miocene. This finding represents the first record of a member of the Scelidotheriinae from the Chasicoan Stage/Age and provides new information about the anatomical characteristics and the geographic distribution of the Neogene representatives of this subfamily.La subfamilia Scelidotheriinae constituye un grupo de milodóntidos ampliamente representados en el Cuaternario de América del Sur. Sin embargo, el registro fósil de los taxa del Neógeno es aun escaso. En este trabajo se presenta un nuevo ejemplar de esta subfamilia, correspondiente a un fragmento de hemimandíbula derecha con la serie dentaria completa. El material fue recuperado de los niveles inferiores del Miembro Arenisca Albardón de la Formación Loma de Las Tapias (Provincia de San Juan, Argentina), asignados al Mioceno tardío. Este hallazgo representa el primer registro de un Scelidotheriinae para el Piso/Edad Chasiquense y aporta nueva información sobre las características anatómicas y la distribución geográfica de los representantes neógenos de esta subfamilia