11 research outputs found

    Locally Optimal Reach Set Over-approximation for Nonlinear Systems

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    Safety verification of embedded systems modeled as hybrid systems can be scaled up by employing simulation-guided reach set over-approximation techniques. Existing methods are applicable only to restricted classes of systems, overly conservative, or computationally expensive. We present new techniques to compute a locally optimal bloating factor based on discrepancy functions, which allow construction of reach set over-approximations from simulation traces for general nonlinear systems. The discrepancy functions are critical for tools like C2E2 to verify bounded time safety properties for complex hybrid systems with nonlinear continuous dynamics. The new discrepancy function is computed using local bounds on a matrix measure under an optimal metric such that the exponential change rate of the discrepancy function is minimized. The new technique is less time consuming and less conservative than existing techniques and does not incur significant computational overhead. We demonstrate the effectiveness of our approach by comparing the performance of a prototype implementation with the state-of-the-art reachability analysis tool Flow*.National Science Foundation/CCF 1422798Ope

    Cholinergic Activation of M2 Receptors Leads to Context-Dependent Modulation of Feedforward Inhibition in the Visual Thalamus

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    The temporal dynamics of inhibition within a neural network is a crucial determinant of information processing. Here, the authors describe in the visual thalamus how neuromodulation governs the magnitude and time course of inhibition in an input-dependent way

    Parameter Synthesis Through Temporal Logic Specifications

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    Parameters are often used to tune mathematical models and capture nondeterminism and uncertainty in physical and engineering systems. This paper is concerned with parametric nonlinear dynamical systems and the problem of determining the parameter values that are consistent with some expected properties. In our previous works, we proposed a parameter synthesis algorithm limited to safety properties and demonstrated its applications for biological systems. Here we consider more general properties specified by a fragment of STL (Signal Temporal Logic), which allows us to deal with complex behavioral patterns that biological processes exhibit. We propose an algorithm for parameter synthesis w.r.t. a property specified using the considered logic. It exploits reachable set computations and forward refinements. We instantiate our algorithm in the case of polynomial dynamical systems exploiting Bernstein coefficients and we illustrate it on an epidemic model

    Figures de l'émigration dans la littérature égyptienne

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    Alors que l’émigration est très présente dans la littérature égyptienne, il n’existe pas de recherche approfondie, consacrée strictement à ce thème. Cette journée a un double objectif : d’une part, développer une approche pluridisciplinaire, en demandant à des chercheurs d’horizons différents (littérature arabe, anthropologie, géographie…) de dresser un panorama des représentations plurielles de l’émigration et des différentes figures de l’émigré, et d’autre part se saisir de cet exemple pour s’interroger sur la richesse des rapports entre littérature et sciences sociales

    Radiofrequency Biology: In vivo

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