The crusades, Catholic piety and chivalry in the novels of Walter Scott

This article explores the themes of crusading, catholic piety and chivalry in two novels of Walter Scott: 'Ivanhoe' and 'The Talisman'

Impaired CD8+ T-Cell Reactivity against Viral Antigens in Cancer Patients with Solid Tumors

Abstract. : Background: : Patients with hematological malignancies are at increased risk for various infections. In patients with solid cancer, a variety of immunosuppressive mechanisms affecting T-cell response are described. We hypothesized that patients with advanced solid tumors may exhibit an impaired recognition of viral antigens. To test this, the capability of CD8+ T cells to recognize recall antigens from influenza and vaccinia virus was compared in patients and healthy individuals. Since all patients and most of the healthy individuals had been vaccinated against vaccinia years ago, comparison of the two groups was expected to be especially informative with respect to distinct effector T-cell reactivity. Materials and Methods: : Our test population included 16 healthy individuals and 12 patients with advanced solid cancers who were currently not receiving chemotherapy. We stimulated peripheral blood mononuclear cells (PBMC) ex vivo with the well-characterized influenza A matrix 58-66 peptide and the immunogenic and HLA-A*0201 restricted peptide epitope SLSAYIIRV derived from the modified vaccinia virus Ankara (MVA). A specific CD8+ T-cell reactivity was determined by quantitative real-time polymerase chain reaction (qRT-PCR) measuring changes in interferon gamma (IFN-γ) mRNA expression levels. Results: : We found that significantly fewer cancer patients than healthy individuals exhibited specific T-cell recognition of the vaccinia epitope (25% and 69%, respectively). In addition, strength of the T-cell responses against both viral peptides was significantly reduced in cancer patients. Conclusion: : Patients with advanced tumors are less likely to mount a T-cell response against viral epitopes. These findings may have implications for the design of immunotherapeutic interventions against virus-induced diseases, including tumor

Satellite geological and geophysical remote sensing of Iceland: Preliminary results from analysis of MSS imagery

A binational, multidisciplinary research effort in Iceland is directed at an analysis of MSS imagery from ERTS-1 to study a variety of geologic, hydrologic, oceanographic, and agricultural phenomena. A preliminary evaluation of available MSS imagery of Iceland has yielded several significant results - some of which may have direct importance to the Icelandic economy. Initial findings can be summarized as follows: (1) recent lava flows can be delineated from older flows at Askja and Hekla; (2) MSS imagery from ERTS-1 and VHRR visible and infrared imagery from NOAA-2 recorded the vocanic eruption on Heimaey, Vestmann Islands; (3) coastline changes, particularly changes in the position of bars and beaches along the south coast are mappable; and (4) areas covered with new and residual snow can be mapped, and the appearance of newly fallen snow on ERTS-1, MSS band 7 appears dark where it is melting. ERTS-1 imagery provides a means of updating various types of maps of Iceland and will permit the compilation of special maps specifically aimed at those dynamic environmental phenomena which impact on the Icelandic economy

Satellite geological and geophysical remote sensing of Iceland: Preliminary results of geologic, hydrologic, oceanographic, and agricultural studies with ERTS-1 imagery

The author has identified the following significant results. The wide variety of geological and geophysical phenomena which can be observed in Iceland, and particularly their very direct relation to the management of the country's natural resources, has provided great impetus to the use of ERTS-1 imagery to measure and map the dynamic natural phenomena in Iceland. MSS imagery is being used to study a large variety of geological and geophysical eruptive products, geologic structure, volcanic geomorphology, hydrologic, oceanographic, and agricultural phenomena of Iceland. Some of the preliminary results from this research projects are: (1) a large number of geological and volcanic features can be studied from ERTS-1 imagery, particularly imagery acquired at low sun angle, which had not previously been recognized; (2) under optimum conditions the ERTS-1 satellite can discern geothermal areas by their snow melt pattern or warm spring discharge into frozen lakes; (3) various maps at scales of 1:1 million and 1:500,000 can be updated and made more accurate with ERTS-1 imagery; (4) the correlation of water reserves with snowcover can improve the basis for planning electrical production in the management of water resources; (5) false-color composites (MSS) permitted the mapping of four types of vegetation: forested; grasslands, reclaimed, and cultivated areas, and the seasonal change of the vegetation, all of high value to rangeland management

The use of traditional ecological knowledge in forest management: an example from India

Many forest communities possess considerable knowledge of the natural resources they use. Such knowledge can potentially inform scientific approaches to management, either as a source of baseline data to fill information gaps that cannot otherwise be addressed or to provide alternative management approaches from which scientists and managers might learn. In general, however, little attention has been given to the relevance of quantitative forms of such knowledge for resource management. Much discussion has focused on the integration of traditional ecological knowledge (TEK) into management, but less attention has been paid to identifying specific areas where it is most useful and where it may be most problematic. We contrasted scientific data with information from TEK in the context of a threat to the sustainable harvesting of a nontimber forest product (NTFP) of livelihood importance in southern India, specifically, a fruit tree infected by mistletoe. The efficiency of deriving information from NTFP harvesters compared to scientific field studies was assessed. We further evaluated the potential of TEK to provide novel solutions to the management problem in question, the degree to which TEK could provide quantitative information, and the biases that might be associated with information derived from TEK. TEK complemented previously gathered ecological data by providing concordant and additional information, but also contradicted some results obtained using a scientific approach. TEK also gave a longer-term perspective with regard to NTFP harvesting patterns. Combining information on historical and current harvesting trends for the NTFP with official data suggests that current assessments of sustainability may be inaccurate and that the use of diverse information sources may provide an effective approach to assessing the status of harvested resources

T cell epitope clustering in the highly immunogenic BZLF1 antigen of Epstein-Barr virus

Polymorphism in the human leukocyte antigen (HLA) loci ensures that the CD8 T cell response to viruses is directed against a diverse range of antigenic epitopes, thereby minimizing the impact of virus escape mutation across the population. The BZLF1 antigen of Epstein-Barr virus is an immunodominant target for CD8 T cells, but the response has been characterized only in the context of a limited number of HLA molecules due to incomplete epitope mapping. We have now greatly expanded the number of defined CD8 T cell epitopes from BZLF1, allowing the response to be evaluated in a much larger proportion of the population. Some regions of the antigen fail to be recognized by CD8 T cells, while others include clusters of overlapping epitopes presented by different HLA molecules. These highly immunogenic regions of BZLF1 include polymorphic sequences, such that up to four overlapping epitopes are impacted by a single amino acid variation common in different regions of the world. This focusing of the immune response to limited regions of the viral protein could be due to sequence similarity to human proteins creating "immune blind spots" through self-tolerance. This study significantly enhances the understanding of the immune response to BZLF1, and the precisely mapped T cell epitopes may be directly exploited in vaccine development and adoptive immunotherapy

REGULATION OF CORONARY BLOOD FLOW DURING ETHER AND HALOTHANE ANAESTHESIA

SUMMARY The effects of ether (6-10%) and halothane (1-2%) were studied on coronary flow regulation in dogs. In one group of experiments the kft coronary artery was perfused mechanically, coronary perfusion pressure being either kept constant or adjusted to aortic pressure, and the heart itself had to pump the blood to all other arteries. The preload on the heart was changed by varying die intravascular volume. In another group, bodi coronary arteries were perfused mechanically under constant pressure; the other arteries were also perfused mechanically by a cardiopulmonary bypass. In this group measurements were carried out on the empty beating heart. Halothane had a direct effect on die heart, myocardial contractility was reduced, cardiac work and myocardial oxygen consumption were diminished and coronary vasoconstriction followed. Edier effects on the heart were principally die same as diose due to halodiane, but to a lesser degree. Coronary vasoconstriction caused by halodiane did not produce myocardial hypoxia. Coronary vasoconstriction occurred as an autorcgulatory mechanism preventing "unnecessary ” hyperperfusion as long as cardiac work and oxygen consumption were diminished. Bodi edier and halodiane reduced systemic vascular resistanc

Accuracy of UAV Photogrammetry in Glacial and Periglacial Alpine Terrain: A Comparison With Airborne and Terrestrial Datasets

Unoccupied Aerial Vehicles (UAVs) equipped with optical instruments are increasingly deployed in high mountain environments to investigate and monitor glacial and periglacial processes. The comparison and fusion of UAV data with airborne and terrestrial data offers the opportunity to analyse spatio-temporal changes in the mountains and to upscale findings from local UAV surveys to larger areas. However, due to the lack of gridded high-resolution data in alpine terrain, the specific challenges and uncertainties associated with the comparison and fusion of multi-temporal data from different platforms in this environment are not well known. Here we make use of UAV, airborne, and terrestrial data from four (peri)glacial alpine study sites with different topographic settings. The aim is to assess the accuracy of UAV photogrammetric products in complex terrain, to point out differences to other products, and to discuss best practices regarding the fusion of multi-temporal data. The surface geometry and characteristic geomorphological features of the four alpine sites are well captured by the UAV data, but the positional accuracies vary greatly. They range from 15 cm (root-mean-square error) for the smallest survey area (0.2 km2) with a high ground control point (GCP) density (40 GCPs km−2) to 135 cm for the largest survey area (>2.5 km2) with a lower GCP density (<10 GCPs km−2). Besides a small number and uneven distribution of GCPs, a low contrast, and insufficient lateral image overlap (<50–70%) seem to be the main causes for the distortions and artefacts found in the UAV data. Deficiencies both in the UAV and airborne data are the reason for horizontal deviations observed between the datasets. In steep terrain, horizontal deviations of a few decimetres may result in surface elevation change errors of several metres. An accurate co-registration and evaluation of multi-temporal UAV, airborne, and terrestrial data using tie points in stable terrain is therefore of utmost importance when it comes to the investigation of surface displacements and elevation changes in the mountains. To enhance the accuracy and quality of UAV photogrammetry, the use of UAVs equipped with multi-spectral cameras and high-precision positioning systems is recommended, especially in rugged terrain and snow-covered areas