Microfluidics: Fluid physics at the nanoliter scale

Microfabricated integrated circuits revolutionized computation by vastly reducing the space, labor, and time required for calculations. Microfluidic systems hold similar promise for the large-scale automation of chemistry and biology, suggesting the possibility of numerous experiments performed rapidly and in parallel, while consuming little reagent. While it is too early to tell whether such a vision will be realized, significant progress has been achieved, and various applications of significant scientific and practical interest have been developed. Here a review of the physics of small volumes (nanoliters) of fluids is presented, as parametrized by a series of dimensionless numbers expressing the relative importance of various physical phenomena. Specifically, this review explores the Reynolds number Re, addressing inertial effects; the Péclet number Pe, which concerns convective and diffusive transport; the capillary number Ca expressing the importance of interfacial tension; the Deborah, Weissenberg, and elasticity numbers De, Wi, and El, describing elastic effects due to deformable microstructural elements like polymers; the Grashof and Rayleigh numbers Gr and Ra, describing density-driven flows; and the Knudsen number, describing the importance of noncontinuum molecular effects. Furthermore, the long-range nature of viscous flows and the small device dimensions inherent in microfluidics mean that the influence of boundaries is typically significant. A variety of strategies have been developed to manipulate fluids by exploiting boundary effects; among these are electrokinetic effects, acoustic streaming, and fluid-structure interactions. The goal is to describe the physics behind the rich variety of fluid phenomena occurring on the nanoliter scale using simple scaling arguments, with the hopes of developing an intuitive sense for this occasionally counterintuitive world

Babylon in the Greek Imaginaire

Babylon held a particularly special place in the Greek imaginaire as a cultural and literary cross-roads: it was space symbolic of the cultural hybridity and suppression of the imperial period, but also a space capable of captivating the historical, scientific, magical and fictional imagination. This study considers different lenses through which the Greeks viewed Babylon, covering a wide range of sources spanning from fifth century BCE up until the third/fourth century CE, which includes historiographies, biographies, magico-medical texts, comic dialogues, and the ancient novel. This thesis explores impressions of Babylon in Greek literature, how on one hand it was presented as a space of esoteric wisdom, and on the other, a dangerous and sensationalised space, and how these two strands of the imagination combined in the form of the ancient novel

The Observations of Redshift Evolution in Large-Scale Environments (ORELSE) Survey. I. The Survey Design and First Results on CL 0023+0423 at z = 0.84 and RX J1821.6+6827 at z = 0.82

We present the Observations of Redshift Evolution in Large-Scale Environments (ORELSE) Survey, a systematic search for structure on scales greater than 10 h^(–1)_70 Mpc around 20 well-known clusters at redshifts of 0.6 < z < 1.3. The goal of the survey is to examine a statistical sample of dynamically active clusters and large-scale structures in order to quantify galaxy properties over the full range of local and global environments. We describe the survey design, the cluster sample, and our extensive observational data covering at least 25' around each target cluster. We use adaptively smoothed red galaxy density maps from our wide-field optical imaging to identify candidate groups/clusters and intermediate-density large-scale filaments/walls in each cluster field. Because photometric techniques (such as photometric redshifts, statistical overdensities, and richness estimates) can be highly uncertain, the crucial component of this survey is the unprecedented amount of spectroscopic coverage. We are using the wide-field, multiobject spectroscopic capabilities of the Deep Multiobject Imaging Spectrograph to obtain 100-200+ confirmed cluster members in each field. Our survey has already discovered the Cl 1604 supercluster at z ≈ 0.9, a structure which contains at least eight groups and clusters and spans 13 Mpc × 100 Mpc. Here, we present the results on the large-scale environments of two additional clusters, Cl 0023+0423 at z = 0.84 and RX J1821.6+6827 at z = 0.82, which highlight the diversity of global properties at these redshifts. The optically selected Cl 0023+0423 is a four-way group-group merger with constituent groups having measured velocity dispersions between 206 and 479 km s^–1. The galaxy population is dominated by blue, star-forming galaxies, with 80% of the confirmed members showing [O II] emission. The strength of the Hδ line in a composite spectrum of 138 members indicates a substantial contribution from recent starbursts to the overall galaxy population. In contrast, the X-ray-selected RX J1821.6+6827 is a largely isolated, massive cluster with a measured velocity dispersion of 926 ± 77 km s^(–1). The cluster exhibits a well-defined red sequence with a large quiescent galaxy population. The results from these two targets, along with preliminary findings on other ORELSE clusters, suggest that optical selection may be more effective than X-ray surveys at detecting less-evolved, dynamically active systems at these redshifts

Property Rights in a Fishery: Regulatory Change and Firm Performance

A new method is introduced and applied to analyse changes in productivity of firms harvesting a natural capital stock. The index-number technique decomposes the contributions of output prices, variable input prices, fixed inputs and productivity to firm profits, adjusted for changes in the natural capital stock. An application of the method is given using micro-level data from a common-pool resource. The indexes provide a ready-made comparison of all firms to the most profitable firm per unit of resource stock. Benchmarking with the decompositions also allows firms and regulators to determine what components are contributing most to economic profits and improve overall industry performance.productivity,profits,natural capital,index numbers

Kinetics and mechanism of the interconversion of inverse bicontinuous cubic mesophases

This paper describes time-resolved x-ray diffraction data monitoring the transformation of one inverse bicontinuous cubic mesophase into another, in a hydrated lipid system. The first section of the paper describes a mechanism for the transformation that conserves the topology of the bilayer, based on the work of Charvolin and Sadoc, Fogden and Hyde, and Benedicto and O'Brien in this area. We show a pictorial representation of this mechanism, in terms of both the water channels and the lipid bilayer. The second section describes the experimental results obtained. The system under investigation was 2:1 lauric acid: dilauroylphosphatidylcholine at a hydration of 50% water by weight. A pressure-jump was used to induce a phase transition from the gyroid (Q(II)(G)) to the diamond (Q(II)(D)) bicontinuous cubic mesophase, which was monitored by time-resolved x-ray diffraction. The lattice parameter of both mesophases was found to decrease slightly throughout the transformation, but at the stage where the Q(II)(D) phase first appeared, the ratio of lattice parameters of the two phases was found to be approximately constant for all pressure-jump experiments. The value is consistent with a topology-preserving mechanism. However, the polydomain nature of our sample prevents us from confirming that the specific pathway is that described in the first section of the paper. Our data also reveal signals from two different intermediate structures, one of which we have identified as the inverse hexagonal (H-II) mesophase. We suggest that it plays a role in the transfer of water during the transformation. The rate of the phase transition was found to increase with both temperature and pressure-jump amplitude, and its time scale varied from the order of seconds to minutes, depending on the conditions employed

Improvement of Renormalization-Scale Uncertainties Within Empirical Determinations of the b-Quark Mass

Accurate determinations of the MS-bar b-quark mass $m_b(m_b)$ from $\sigma(e^+e^-\to{\rm hadrons})$ experimental data currently contain three comparable sources of uncertainty; the experimental uncertainty from moments of this cross-section, the uncertainty associated with $\alpha_s(M_z)$, and the theoretical uncertainty associated with the renormalization scale. Through resummation of all logarithmic terms explicitly determined in the perturbative series by the renormalization-group (RG) equation, it is shown that the renormalization-scale dependence is virtually eliminated as a source of theoretical uncertainty in $m_b(m_b)$. This resummation also reduces the estimated effect of higher-loop perturbative contributions, further reducing the theoretical uncertainties in $m_b(m_b)$. Furthermore, such resummation techniques improve the agreement between the values of the MS-bar b-quark mass extracted from the various moments of $R(s)=\sigma(e^+e^-\to{\rm hadrons})/\sigma_{pt}$ [$\sigma_{pt}=4\pi\alpha^2/(3s)$], obviating the need to choose an optimummoment for determining $m_b(m_b)$. Resummation techniques are also shown to reduce renormalization-scale dependence in the relation between b-quark MS-bar and pole mass and in the relation between the pole and $1S$ mass.Comment: 19 pages, latex2e, 6 eps figures contained in latex file. Errors corrected in equations (20)--(22