Importance of 1n1n-stripping process in the 6^{6}Li+159^{159}Tb reaction

The inclusive cross sections of the $\alpha$-particles produced in the reaction $^{6}$Li+$^{159}$Tb have been measured at energies around the Coulomb barrier. The measured cross sections are found to be orders of magnitude larger than the calculated cross sections of $^{6}$Li breaking into $\alpha$ and $d$ fragments, thus indicating contributions from other processes. The experimental cross sections of $1n$-stripping and $1n$-pickup processes have been determined from an entirely different measurement, reported earlier. Apart from incomplete fusion and/ $d$-transfer processes, the $1n$-stripping process is found to be a significant contributor to the inclusive $\alpha$-particle cross sections in this reaction

Aplikasi Pembelajaran Rangkaian Listrik Sederhana Berbasis Android

Physics is one of the science subjects which learns about natural phenomena in our surroundings. One of the topics learnt in physics is Electric Circuit. Many people nowadays lack the understanding of the theories, calculation formulae, and practices of the electric circuit. Even though the electric circuit is indispensable and one of the physics topics that is used in everyday\u27s life. People are often not interested in learning theories and formulae from the book, while the electric circuit\u27s practices require components and supporting substances. This leads to a new matter because sometimes there are substances that are too hard to find and get.This manuscript discusses the development of an Android-based application for learning simple electric circuits. Android is chosen because it is one of the smartphone\u27s operating systems that is aggresively growing. This application employs a drag and drop method, which consists of dragging the desired object and dropping it at a particular position. The application was developed using Java programming language, Eclipse, and MySQL as its database.Based on the system testing that has been done, the developed application allows a user to login to the system, register him/herself, display simple electric circuit materials, display simulation that will be useful for the user in designing a simple electric circuit with its specified components and the calculation, try quizzes to test his/her knowledge, display user\u27s scores, and update materials and quizzes. This application needs internet connection to register, login, display images, and update data

Mutant p53 establishes targetable tumor dependency by promoting unscheduled replication

Gain-of-function (GOF) p53 mutations are observed frequently in most intractable human cancers and establish dependency for tumor maintenance and progression. While some of the genes induced by GOF p53 have been implicated in more rapid cell proliferation compared with p53-null cancer cells, the mechanism for dependency of tumor growth on mutant p53 is unknown. This report reveals a therapeutically targetable mechanism for GOF p53 dependency. We have shown that GOF p53 increases DNA replication origin firing, stabilizes replication forks, and promotes micronuclei formation, thus facilitating the proliferation of cells with genomic abnormalities. In contrast, absence or depletion of GOF p53 leads to decreased origin firing and a higher frequency of fork collapse in isogenic cells, explaining their poorer proliferation rate. Following genome-wide analyses utilizing ChIP-Seq and RNA-Seq, GOF p53–induced origin firing, micronuclei formation, and fork protection were traced to the ability of GOF p53 to transactivate cyclin A and CHK1. Highlighting the therapeutic potential of CHK1’s role in GOF p53 dependency, experiments in cell culture and mouse xenografts demonstrated that inhibition of CHK1 selectively blocked proliferation of cells and tumors expressing GOF p53. Our data suggest the possibility that checkpoint inhibitors could efficiently and selectively target cancers expressing GOF p53 alleles