191 research outputs found
Strontium optical lattice clocks for practical realization of the metre and secondary representation of the second
We present a system of two independent strontium optical lattice standards
probed with a single shared ultra-narrow laser. The absolute frequency of the
clocks can be verified by the use of Er:fiber optical frequency comb with the
GPS-disciplined Rb frequency standard. We report hertz-level spectroscopy of
the clock line and measurements of frequency stability of the two strontium
optical lattice clocks.Comment: This is an author-created, un-copyedited version of an article
accepted for publication in Meas. Sci. Technol. The publisher is not
responsible for any errors or omissions in this version of the manuscript or
any version derived from it. The Version of Record is available online at
doi:10.1088/0957-0233/26/7/07520
Fibre-optic delivery of time and frequency to VLBI station
The quality of Very Long Baseline Interferometry (VLBI) radio observations
predominantly relies on precise and ultra-stable time and frequency (T&F)
standards, usually hydrogen masers (HM), maintained locally at each VLBI
station. Here, we present an operational solution in which the VLBI
observations are routinely carried out without use of a local HM, but using
remote synchronization via a stabilized, long-distance fibre-optic link. The
T&F reference signals, traceable to international atomic timescale (TAI), are
delivered to the VLBI station from a dedicated timekeeping laboratory.
Moreover, we describe a proof-of-concept experiment where the VLBI station is
synchronized to a remote strontium optical lattice clock during the
observation.Comment: 8 pages, 8 figures, matches the version published in A&A, section
Astronomical instrumentatio
Nonlocal effects in high energy charged particle beams
Within the framework of the thermal wave model, an investigation is made of
the longitudinal dynamics of high energy charged particle beams. The model
includes the self-consistent interaction between the beam and its surroundings
in terms of a nonlinear coupling impedance, and when resistive as well as
reactive parts are included, the evolution equation becomes a generalised
nonlinear Schroedinger equation including a nonlocal nonlinear term. The
consequences of the resistive part on the propagation of particle bunches are
examined using analytical as well as numerical methods.Comment: 6 pages, 6 figures, uses RevTeX
Statistical Theory for Incoherent Light Propagation in Nonlinear Media
A novel statistical approach based on the Wigner transform is proposed for
the description of partially incoherent optical wave dynamics in nonlinear
media. An evolution equation for the Wigner transform is derived from a
nonlinear Schrodinger equation with arbitrary nonlinearity. It is shown that
random phase fluctuations of an incoherent plane wave lead to a Landau-like
damping effect, which can stabilize the modulational instability. In the limit
of the geometrical optics approximation, incoherent, localized, and stationary
wave-fields are shown to exist for a wide class of nonlinear media.Comment: 4 pages, REVTeX4. Submitted to Physical Review E. Revised manuscrip
Use of Magnetic Resonance Imaging as Well as Clinical Disease Activity in the Clinical Classification of Multiple Sclerosis and Assessment of Its Course
An extended association screen in multiple sclerosis using 202 microsatellite markers targeting apoptosis-related genes does not reveal new predisposing factors
Apoptosis, the programmed death of cells, plays a distinct role in the etiopathogenesis of Multiple sclerosis (MS), a common disease of the central nervous system with complex genetic background. Yet, it is not clear whether the impact of apoptosis is due to altered apoptotic behaviour caused by variations of apoptosis-related genes. Instead, apoptosis in MS may also represent a secondary response to cellular stress during acute inflammation in the central nervous system. Here, we screened 202 apoptosis-related genes for association by genotyping 202 microsatellite markers in initially 160 MS patients and 160 controls, both divided in 4 sets of pooled DNA samples, respectively. When applying Bonferroni correction, no significant differences in allele frequencies were detected between MS patients and controls. Nevertheless, we chose 7 markers for retyping in individual DNA samples, thereby eliminating 6 markers from the list of candidates. The remaining candidate, the ERBB3 gene microsatellite, was genotyped in additional 245 MS patients and controls. No association of the ERBB3 marker with the disease was detected in these additional cohorts. In consequence, we did not find further evidence for apoptosis-related genes as predisposition factors in MS
Spatiotemporal solitons in multidimensional optical media with a quadratic nonlinearity
We consider solutions to the second-harmonic generation equations in two-and three-dimensional dispersive media in the form of solitons localized in space and time. As is known, collapse does not take place in these models, which is why the solitons may be stable. The general solution is obtained in an approximate analytical form by means of a variational approach, which also allows the stability of the solutions to be predicted. Then, we directly simulate the two-dimensional case, taking the initial configuration as suggested by the variational approximation. We thus demonstrate that spatiotemporal solitons indeed exist and are stable. Furthermore, they are not, in the general case, equivalent to the previously known cylindrical spatial solitons. Direct simulations generate solitons with some internal oscillations. However, these oscillations neither grow nor do they exhibit any significant radiative damping. Numerical solutions of the stationary version of the equations produce the same solitons in their unperturbed form, i.e., without internal oscillations. Strictly stable solitons exist only if the system has anomalous dispersion at both the fundamental harmonic and second harmonic (SH), including the case of zero dispersion at SH. Quasistationary solitons, decaying extremely slowly into radiation, are found in the presence of weak normal dispersion at the second-harmonic frequency
The prevalence of psychiatric symptoms before the diagnosis of Parkinson's disease in a nationwide cohort: A comparison to patients with cerebral infarction
Objectives Psychiatric symptoms (PS) can be non-motor features in Parkinson's disease (PD) which are common even in the prodromal, untreated phase of the disease. Some PS, especially depression and anxiety recently became known predictive markers for PD. Our objective was to explore retrospectively the prevalence of PS before the diagnosis of PD. Methods In the framework of the Hungarian Brain Research Program we created a database from medical and medication reports submitted for reimbursement purposes to the National Health Insurance Fund in Hungary, a country with 10 million inhabitants and a single payer health insurance system. We used record linkage to evaluate the prevalence of PS before the diagnosis of PD and compared that with patients with ischemic cerebrovascular lesion (ICL) in the period between 2004-2016 using ICD-10 codes of G20 for PD, I63-64 for ICL and F00-F99 for PS. We included only those patients who got their PD, ICL and psychiatric diagnosis at least twice. Results There were 79 795 patients with PD and 676 874 patients with ICL. Of the PD patients 16% whereas of those with ischemic cerebrovascular lesion 9.7% had a psychiatric diagnosis before the first appearance of PD or ICL (p<0.001) established in psychiatric care at least twice. The higher rate of PS in PD compared to ICL remained significant after controlling for age and gender in logistic regression analysis. The difference between PD and ICL was significant for Mood disorders (F30-F39), Organic, including symptomatic, mental disorders (F00-F09), Neurotic, stress-related and somatoform disorders (F40-F48) and Schizophrenia, schizotypal and delusional disorders (F20-F29) diagnosis categories (p<0.001, for all). Discussion The higher rate of psychiatric morbidity in the premotor phase of PD may reflect neurotransmitter changes in the early phase of PD
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