410 research outputs found
Handling Overlapping Asymmetric Data Sets—A Twice Penalized P-Spline Approach
\ua9 2024 by the authors.Aims: Overlapping asymmetric data sets are where a large cohort of observations have a small amount of information recorded, and within this group there exists a smaller cohort which have extensive further information available. Missing imputation is unwise if cohort size differs substantially; therefore, we aim to develop a way of modelling the smaller cohort whilst considering the larger. Methods: Through considering traditionally once penalized P-Spline approximations, we create a second penalty term through observing discrepancies in the marginal value of covariates that exist in both cohorts. Our now twice penalized P-Spline is designed to firstly prevent over/under-fitting of the smaller cohort and secondly to consider the larger cohort. Results: Through a series of data simulations, penalty parameter tunings, and model adaptations, our twice penalized model offers up to a 58% and 46% improvement in model fit upon a continuous and binary response, respectively, against existing B-Spline and once penalized P-Spline methods. Applying our model to an individual’s risk of developing steatohepatitis, we report an over 65% improvement over existing methods. Conclusions: We propose a twice penalized P-Spline method which can vastly improve the model fit of overlapping asymmetric data sets upon a common predictive endpoint, without the need for missing data imputation
Comments on alternative calculations of the broadening of spectral lines of neutral sodium by H-atom collisions
With the exception of the sodium D-lines recent calculations of line
broadening cross-sections for several multiplets of sodium by Leininger et al
(2000) are in substantial disagreement with cross-sections interpolated from
the tables of Anstee and O'Mara (1995) and Barklem and O'Mara (1997). The
discrepancy is as large as a factor of three for the 3p-4d multiplet. The two
theories are tested by using the results of each to synthesize lines in the
solar spectrum. It is found that generally the data from the theory of Anstee,
Barklem and O'Mara produce the best match to the observed solar spectrum. It is
found, using a simple model for reflection of the optical electron by the
potential barrier between the two atoms, that the reflection coefficient is too
large for avoided crossings with the upper states of subordinate lines to
contribute to line broadening, supporting the neglect of avoided ionic
crossings by Anstee, Barklem and O'Mara for these lines. The large
discrepancies between the two sets of calculations is a result of an
approximate treatment of avoided ionic crossings for these lines by Leininger
et al (2000).Comment: 18 pages, 5 ps figures included, to appear in J Phys B: At. Mol. Opt.
Phy
First-Digit Law in Nonextensive Statistics
Nonextensive statistics, characterized by a nonextensive parameter , is a
promising and practically useful generalization of the Boltzmann statistics to
describe power-law behaviors from physical and social observations. We here
explore the unevenness of the first digit distribution of nonextensive
statistics analytically and numerically. We find that the first-digit
distribution follows Benford's law and fluctuates slightly in a periodical
manner with respect to the logarithm of the temperature. The fluctuation
decreases when increases, and the result converges to Benford's law exactly
as approaches 2. The relevant regularities between nonextensive statistics
and Benford's law are also presented and discussed.Comment: 11 pages, 3 figures, published in Phys. Rev.
Optimal General Matchings
Given a graph and for each vertex a subset of the
set , where denotes the degree of vertex
in the graph , a -factor of is any set such that
for each vertex , where denotes the number of
edges of incident to . The general factor problem asks the existence of
a -factor in a given graph. A set is said to have a {\em gap of
length} if there exists a natural number such that and . Without any restrictions the
general factor problem is NP-complete. However, if no set contains a gap
of length greater than , then the problem can be solved in polynomial time
and Cornuejols \cite{Cor} presented an algorithm for finding a -factor, if
it exists. In this paper we consider a weighted version of the general factor
problem, in which each edge has a nonnegative weight and we are interested in
finding a -factor of maximum (or minimum) weight. In particular, this
version comprises the minimum/maximum cardinality variant of the general factor
problem, where we want to find a -factor having a minimum/maximum number of
edges.
We present an algorithm for the maximum/minimum weight -factor for the
case when no set contains a gap of length greater than . This also
yields the first polynomial time algorithm for the maximum/minimum cardinality
-factor for this case
The Carina Project. V. The impact of NLTE effects on the iron content
We have performed accurate iron abundance measurements for 44 red giants
(RGs) in the Carina dwarf spheroidal (dSph) galaxy. We used archival,
high-resolution spectra (R~38,000) collected with UVES at ESO/VLT either in
slit mode (5) or in fiber mode (39, FLAMES/GIRAFFE-UVES). The sample is more
than a factor of four larger than any previous spectroscopic investigation of
stars in dSphs based on high-resolution (R>38,000) spectra. We did not impose
the ionization equilibrium between neutral and singly-ionized iron lines. The
effective temperatures and the surface gravities were estimated by fitting
stellar isochrones in the V, B-V color-magnitude diagram. To measure the iron
abundance of individual lines we applied the LTE spectrum synthesis fitting
method using MARCS model atmospheres of appropriate metallicity. We found
evidence of NLTE effects between neutral and singly-ionized iron abundances.
Assuming that the FeII abundances are minimally affected by NLTE effects, we
corrected the FeI stellar abundances using a linear fit between FeI and FeII
stellar abundance determinations.
We found that the Carina metallicity distribution based on the corrected FeI
abundances (44 RGs) has a weighted mean metallicity of [Fe/H]=-1.80 and a
weighted standard deviation of sigma=0.24 dex. The Carina metallicity
distribution based on the FeII abundances (27 RGs) gives similar estimates
([Fe/H]=-1.72, sigma=0.24 dex). The current weighted mean metallicities are
slightly more metal poor when compared with similar estimates available in the
literature. Furthermore, if we restrict our analysis to stars with the most
accurate iron abundances, ~20 FeI and at least three FeII measurements (15
stars), we found that the range in iron abundances covered by Carina RGs (~1
dex) agrees quite well with similar estimates based on high-resolution spectra.Comment: Accepted for publication in PASP, 16 pages, 7 figures, 3 tables, 1 MR
table Note: the electronic version of Table1 is included, but commented, in
the tex fil
Isolation and characterization of the major oligosaccharide of human platelet membrane glycoprotein GPIb
Stellar Iron Abundances: non-LTE Effects
We report new statistical equilibrium calculations for Fe I and Fe II in the
atmosphere of Late-Type stars. We used atomic models for Fe I and Fe II having
respectively 256 and 190 levels, as well as 2117 and 3443 radiative
transitions. Photoionization cross-sections are from the Iron Project. These
atomic models were used to investigate non-LTE effects in iron abundances of
Late-Type stars with different atmospheric parameters.
We found that most Fe I lines in metal-poor stars are formed in conditions
far from LTE. We derived metallicity corrections of about 0.3 dex with respect
to LTE values, for the case of stars with [Fe/H] ~ -3.0. Fe II is found not to
be affected by significant non-LTE effects. The main non-LTE effect invoked in
the case of Fe I is overionization by ultraviolet radiation, thus classical
ionization equilibrium is far to be satisfied. An important consequence is that
surface gravities derived by LTE analysis are in error and should be corrected
before final abundances corrections.
This apparently solves the observed discrepancy between spectroscopic surface
gravities derived by LTE analyses and those derived from Hipparcos parallaxes.
A table of non-LTE [Fe/H] and log g values for a sample of metal-poor late-type
stars is given.Comment: 22 pages, 9 figures, 1 table, ApJ style, accepte
Pharmacogene expression during progression of metabolic dysfunction-associated steatotic liver disease: Studies on mRNA and protein levels and their relevance to drug treatment
\ua9 2024. Metabolic dysfunction-associated steatotic liver disease (MASLD) is common worldwide. Genes and proteins contributing to drug disposition may show altered expression as MASLD progresses. To assess this further, we undertook transcriptomic and proteomic analysis of 137 pharmacogenes in liver biopsies from a large MASLD cohort. We performed sequencing on RNA from 216 liver biopsies (206 MASLD and 10 controls). Untargeted mass spectrometry proteomics was performed on a 103 biopsy subgroup. Selected RNA sequencing signals were replicated with an additional 187 biopsies. Comparison of advanced MASLD (fibrosis score 3/4) with milder disease (fibrosis score 0–2) by RNA sequencing showed significant alterations in expression of certain phase I, phase II and ABC transporters. For cytochromes P450, CYP2C19 showed the most significant decreased expression (30 % of that in mild disease) but significant decreased expression of other CYPs (including CYP2C8 and CYP2E1) also occurred. CYP2C19 also showed a significant decrease comparing the inflammatory form of MASLD (MASH) with non-MASH biopsies. Findings for CYP2C19 were confirmed in the replication cohort. Proteomics on the original discovery cohort confirmed decreased levels of several CYPs as MASLD advanced but this decrease was greatest for CYP2C19 where levels fell to 40 % control. This decrease may result in decreased CYP2C19 activity that could be problematic for prescription of drugs activated or metabolized by CYP2C19 as MASLD advances. More limited decreases for other P450s suggest fewer issues with non-CYP2C19 drug substrates. Negative correlations at RNA level between CYP2C19 and several cytokine genes provided initial insights into the mechanism underlying decreased expression
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