The effect of <i>OPRM1, ABCB1, IL1B, PTGS2, LOC 541472</i> gene polymorphism on the variability of chronic pain syndrome in patients with pancreatic cancer

Background. One of the obligate clinical manifestations of pancreatic cancer is chronic pain syndrome, which is realized in 80 % of patients with a progressive course of the disease. Studying the molecular genetic factors that influence the phenotypic realization of chronic pain syndrome in patients with pancreatic cancer is an important step towards personalizing the roadmap.Aims. To study the associative effect of single nucleotide polymorphisms (SNPs) of the OPRM1, ABCB1, IL1B, PTGS2, LOC 541472 genes on the interindividual variability of chronic pain syndrome in patients with pancreatic cancer.Materials and methods. The study included 81 patients aged 18 to 75 years with histological verification, promptly treated for prostate cancer according to the main criterion for inclusion in the study. Molecular genetic studies were performed to determine the allelic variants of rs1799971 of the OPRM1 gene, rs1045642, rs2032582, rs1128503 of the ABCB1 gene, rs1143627 of the IL1B gene, rs5275 of the PTGS2 gene, rs1800795 of the LOC gene 541472. Statistical processing of the results was carried out using the Statistica 10.0 program.Results. Carriers of the homozygous AA genotype of the OPRM1 gene prevailed among the observed patients of the Krasnoyarsk Territory with pancreatic cancer. Genotype AG IL1B showed an increase in the chances of chronic pain by 18,46 times in patients with pancreatic cancer. Carriers of the GG genotypes of the ABCB1 rs1045642 and AA genes of the ABCB1 rs2032582 gene constituted a risk group for the implementation of chronic pain in patients with pancreatic cancer.Conclusions. The study showed that the most significant in terms of increasing the chances of chronic pain in patients with pancreatic cancer are the homo- and heterozygous genotypes of the IL1B and LOC 541472 genes encoding IL-6

Polarization characteristics of light passed through a cholesteric layer with tangential-conical boundary conditions

The present work is devoted to the investigation of the polarization characteristics of light passed through the cholesteric layer with tangential-conical boundary conditions

A convenient synthetic approach to 5-(het)arylhydrazine substituted 1,2,4‑triazines

Received: 09.09.2020. Accepted: 20.12.2020. Published:30.12.2020.A convenient synthesis of 1,2,4‑triazines bearing the moieties of (hetero) arylhydrazines at the position of C5 of the 1,2,4‑triazine core is reported

Reaction of 3-(Pyridin-2-yl)-1,2,4-triazine-5-carbonitriles with 2-Amino-4-aryl-1,3-oxazoles in Anhydrous Medium

Abstract: We previously reported the solvent-free reaction of 5-aryl-3-(pyridin-2-yl)-1,2,4-triazine-5-carbo-nitriles with 2-amino-4-aryl-1,3-oxazoles, which afforded 4,5-diaryl-3-hydroxy-2,2′-bipyridine-6-carbonitriles. Similar reaction in anhydrous medium led to the formation of two products, previously described 4,5-diaryl-3-hydroxy-2,2′-bipyridine-6-carbonitriles (up to 44%) and 4,5-diaryl-2,2′-bipyridine-6-carbonitriles (up to 32%). © 2023, The Author(s).Council on grants of the President of the Russian Federation: MK-320.2021.1.3This study was financially supported by the Council for Grants at the President of the Russian Federation (project no. MK-320.2021.1.3)

REACTIONS OF 1, 2, 4-TRIAZINES WITH 4, 5-DIMETHYL-1, 2-DEHYDROBENZENE

Arynes are known intermediates in reactions with azaheterocycles. However, the reactions of fist ones with 1, 2, 4-trriazines are not well studied so far. In continuation of our studies on interactions of 3, 5-substituted-1, 2, 4-triazines with arynes we wish to report herein our results observed in reactions of these heterocycles with 4, 5-dimethyl-1, 2-dehydrobenzene. This dimethyl-aryne was generated in situ from the corresponding anthranilic acid as precursor by the reaction with iso-Amyl-ONO in 1, 4-dioxane and the following reaction with 5, 6-diaryl-3-(pyridyl-2)-1, 2, 4-trazines 1 in refluxed toluene for 2 hours. In all the cases the reaction afforded the domino-products, namely pyrido[1, 2-a]indoles 2, as major products, while the “classical” ID Diels-Alder products, such as iso-quinolines 3, were obtained only in trace amounts.This work was supported by Russian Science Foundation (Grant # 18-13-00365) and Russian Foundation for Basic Researches (Grant # 19-53-55002)

An Effective Synthetic Approach to of 2-([5'-Aryl-2,2'-bipyridin]-6-yl)-5-aryl-1,3,4-oxadiazoles

Abstract: A convenient synthetic approach to 2-(2,2'-bipyridin-6-yl)-1,3,4-oxadiazole derivatives is proposed, which involves the preparation of 5-aryl-2,2'-bipyridine-6-carboxylic acid esters by the “1,2,4-triazine” methodology and the subsequent construction of the 1,3,4-oxadiazole ring via the modification of the ester group. © 2023, The Author(s).Russian Science Foundation, RSF: 18-73-10119-PThe work was financially supported by the Russian Science Foundation (project no. 18-73-10119-P)

Transperineal saturation biopsy of the prostate: methods, results and complications

According to the results of clinical and pathological studies saturation biopsy are more accurate in comparison with standard techniques. However, the use of this technique as a primary technique is impractical. Clinical relevance with negative initial biopsy results and steady increase in PSA levels and I or the presence of foci according to transrectal ultrasound, and the presence of atypia (ASAP). Increasing the number of biopsies to determine the stage of disease as true. At the same time, a clear positioning of tumor focus is also an important factor. Using a template coordinate system with locking arrangement biopsy cores is a promising technique in the diagnosis of prostate cancer.По результатам клинического и патологического исследования биопсии насыщения являются более точными по сравнению со стандартными методами. Однако использование этого метода в качестве основного метода является непрактичным. Клиническая значимость с отрицательной начальной результаты биопсии и постоянного увеличения уровня ПСА и / или наличия очагов в соответствии с трансректальное УЗИ, и наличием атипии (ASAP). Увеличение количества биопсий для определения стадии заболевания, как правда. В то же время, четкое позиционирование опухолевого очага также является важным фактором. Использование системы координат шаблон с блокировкой ядра аранжировки биопсии является перспективным методом в диагностике рака предстательной железы

Клинико-фармакологические особенности лекарственных взаимодействий опиоидов у пациентов с хроническим болевым синдромом в практической онкологии

The aim of the review was to analyze published studies on the impact of opioid drug-drug interactions on the choice of analgesic therapy regimens.Material and methods. A systematic literature search was conducted using PubMed, Scopus, Web of Science, and E-library databases.Results. The review showed a clinical significance of pharmacokinetic interactions of opioids with other drugs in cancer pain treatment. The problems of individual choice of analgesics from different groups under conditions of co-morbidity and concomitant medication were discussed to ensure the effectiveness/safety of the treatment strategy affecting the quality of life of cancer patients.Conclusion. A comprehensive assessment of factors in patients receiving opioid analgesics is a predictor of effective and safe analgesic therapy.Цель исследования - анализ отечественной и зарубежной литературы о влиянии лекарственных взаимодействий опиоидов на индивидуальный выбор схем анальгетической терапии в онкологии.Материал и методы. Поиск источников производился в системах PubMed, Scopus, Web of Science, E-library.Результаты. В обзоре показано клиническое значение фармакокинетических взаимодействий опиоидов с другими лекарственными средствами в рамках анальгетической терапии хронического болевого синдрома в онкологии. Освещаются вопросы индивидуального выбора анальгетиков разных групп в условиях коморбидности и сопутствующей лекарственной терапии с целью обеспечения эффективности/безопасности стратегии лечения, влияющей на качество жизни пациентов со злокачественными новообразованиями.Заключение. Комплексная оценка факторов у пациентов, получающих опиоидные анальгетики, является предиктором эффективной и безопасной анальгетической терапии

Brachytherapy in patients undergoing transurethral resection of the prostate

The article is devoted to the brachytherapy peculiarities after TURP in patients with prostate cancer. The study includes 47 patients with prostate cancer T1c-T2b, undergone TURP prior the brachytherapy. The results of the study showed that brachytherapy in combination with TURP is an effective and safety method of localized prostate cancer treatment, causing no reduction of life quality.Научная работа посвящена особенностям выполнения брахитерапии больным раком предстательной железы после перенесенной ТУР простаты. В исследование включено 47 пациентов с диагнозом рак предстательной железы в стадиях Т1с-Т2Ь, которым была выполнена трансуретральная резекция предстательной железы и в последующем брахитерапия. Результаты проведенного исследования показали, что применение брахитерапии в комбинации с парциальной трансуретральной резекцией предстательной железы в лечении локализованных форм рака простаты является эффективным и безопасным методом лечения с отсутствием снижения качества жизни

On the results of early diagnosis and treatment of patients with localized prostate cancer in a large industrial region

The main indicators of organization of urological care in Sverdlovsk region were analyzed. The structure of urological and oncourological morbidity in dynamic from 2000 to 2018 was presented. The data of the personnel structure and bed stock of urological service was shown. The effective methods of men treatment with prostate cancer in the year of 45-80 by the modern methods of SOKB №1: brachytherapy, robot-assisted operations, ultrasound ablation HiFU, radical prostatectomy, laser ablation, hormonotherapy – allow us to prove for the soon improvement and use in regions of Sverdlovsk region (Governor’s program “Urological men’s health» in Sverdlovsk region)Проанализированы основные показатели организации урологической помощи в Свердловской области. Представлена структура урологической и онкоурологической заболеваемости в динамике с 2000 по 2018 гг. Приведены данные о кадровом составе и коечном фонде урологической службы. эффективные методы. Лечения мужчин больных раком простаты в возрасте 45-80 лет современными методами СокБ№1: брахитерапия, робот-ассистированные операции, ультразвуковая абляция HiFU, радикальная простатэктомия, лазерная абляция, гормонотерапия и др. позволяют рассчитывать на их скорейшее развитие и внедрение в районах нашей области (Губернаторская программа «Урологическое здоровье мужчины» в Свердловской области)