1,528 research outputs found
Time-bin entangled photon holes
The general concept of entangled photon holes is based on a correlated
absence of photon pairs in an otherwise constant optical background. Here we
consider the specialized case when this background is confined to two
well-defined time bins, which allows the formation of time-bin entangled photon
holes. We show that when the typical coherent state background is replaced by a
true single-photon (Fock state) background, the basic time-bin entangled
photon-hole state becomes equivalent to one of the time-bin entangled
photon-pair states. We experimentally demonstrate these ideas using a
parametric down-conversion photon-pair source, linear optics, and
post-selection to violate a Bell inequality with time-bin entangled photon
holes.Comment: 6 pages, 5 figure
Genetic Variation and Antioxidant Response Gene Expression in the Bronchial Airway Epithelium of Smokers at Risk for Lung Cancer
Prior microarray studies of smokers at high risk for lung cancer have demonstrated that heterogeneity in bronchial airway epithelial cell gene expression response to smoking can serve as an early diagnostic biomarker for lung cancer. As a first step in applying functional genomic analysis to population studies, we have examined the relationship between gene expression variation and genetic variation in a central molecular pathway (NRF2-mediated antioxidant response) associated with smoking exposure and lung cancer. We assessed global gene expression in histologically normal airway epithelial cells obtained at bronchoscopy from smokers who developed lung cancer (SC, n=20), smokers without lung cancer (SNC, n=24), and never smokers (NS, n=8). Functional enrichment analysis showed that the NRF2-mediated, antioxidant response element (ARE)-regulated genes, were significantly lower in SC, when compared with expression levels in SNC. Importantly, we found that the expression of MAFG (a binding partner of NRF2) was correlated with the expression of ARE genes, suggesting MAFG levels may limit target gene induction. Bioinformatically we identified single nucleotide polymorphisms (SNPs) in putative ARE genes and to test the impact of genetic variation, we genotyped these putative regulatory SNPs and other tag SNPs in selected NRF2 pathway genes. Sequencing MAFG locus, we identified 30 novel SNPs and two were associated with either gene expression or lung cancer status among smokers. This work demonstrates an analysis approach that integrates bioinformatics pathway and transcription factor binding site analysis with genotype, gene expression and disease status to identify SNPs that may be associated with individual differences in gene expression and/or cancer status in smokers. These polymorphisms might ultimately contribute to lung cancer risk via their effect on the airway gene expression response to tobacco-smoke exposure.Intramural Research Program of the National Institute of Environmental Health Sciences; National Institutes of Health (Z01 ES100475, U01ES016035, R01CA124640
Quantum interference by two temporally distinguishable pulses
We report a two-photon interference effect, in which the entangled photon
pairs are generated from two laser pulses well-separated in time. In a single
pump pulse case, interference effects did not occur in our experimental scheme.
However, by introducing a second pump pulse delayed in time, quantum
interference was then observed. The visibility of the interference fringes
shows dependence on the delay time between two laser pulses. The results are
explained in terms of indistinguishability of biphoton amplitudes which
originated from two temporally separated laser pulses.Comment: two-column, 4pages, submitted to PRA, minor change
Stigmatizedâ Identity Cues: Threats as Opportunities for Consumer Psychology
Peer Reviewedhttps://deepblue.lib.umich.edu/bitstream/2027.42/146893/1/jcpy1076_am.pdfhttps://deepblue.lib.umich.edu/bitstream/2027.42/146893/2/jcpy1076.pd
All-Optical Switching Demonstration using Two-Photon Absorption and the Classical Zeno Effect
Low-contrast all-optical Zeno switching has been demonstrated in a silicon
nitride microdisk resonator coupled to a hot atomic vapor. The device is based
on the suppression of the field build-up within a microcavity due to
non-degenerate two-photon absorption. This experiment used one beam in a
resonator and one in free-space due to limitations related to device physics.
These results suggest that a similar scheme with both beams resonant in the
cavity would correspond to input power levels near 20 nW.Comment: 4 pages, 5 figure
A Delayed Choice Quantum Eraser
This paper reports a "delayed choice quantum eraser" experiment proposed by
Scully and Dr\"{u}hl in 1982. The experimental results demonstrated the
possibility of simultaneously observing both particle-like and wave-like
behavior of a quantum via quantum entanglement. The which-path or both-path
information of a quantum can be erased or marked by its entangled twin even
after the registration of the quantum.Comment: twocolumn, 4pages, submitted to PR
Role of entanglement in two-photon imaging
The use of entangled photons in an imaging system can exhibit effects that
cannot be mimicked by any other two-photon source, whatever the strength of the
correlations between the two photons. We consider a two-photon imaging system
in which one photon is used to probe a remote (transmissive or scattering)
object, while the other serves as a reference. We discuss the role of
entanglement versus correlation in such a setting, and demonstrate that
entanglement is a prerequisite for achieving distributed quantum imaging.Comment: 15 pages, 2 figure
Tight Finite-Key Analysis for Quantum Cryptography
Despite enormous progress both in theoretical and experimental quantum
cryptography, the security of most current implementations of quantum key
distribution is still not established rigorously. One of the main problems is
that the security of the final key is highly dependent on the number, M, of
signals exchanged between the legitimate parties. While, in any practical
implementation, M is limited by the available resources, existing security
proofs are often only valid asymptotically for unrealistically large values of
M. Here, we demonstrate that this gap between theory and practice can be
overcome using a recently developed proof technique based on the uncertainty
relation for smooth entropies. Specifically, we consider a family of
Bennett-Brassard 1984 quantum key distribution protocols and show that security
against general attacks can be guaranteed already for moderate values of M.Comment: 11 pages, 2 figure
JWST Detects Neon Line Variability in a Protoplanetary Disk
We report the first detection of variability in the mid-infrared neon line
emission of a protoplanetary disk by comparing a JWST MIRI MRS spectrum of SZ
Cha taken in 2023 with a Spitzer IRS SH spectrum of this object from 2008. We
measure the [Ne III]-to-[Ne II] line flux ratio, which is a diagnostic of the
high-energy radiation field, to distinguish between the dominance of EUV- or
X-ray-driven disk photoevaporation. We find that the [Ne III]-to-[Ne II] line
flux ratio changes significantly from in 2008 to in 2023.
This points to a switch from EUV-dominated to X-ray-dominated photoevaporation
of the disk. We present contemporaneous ground-based optical spectra of the
Halpha emission line that show the presence of a strong wind in 2023. We
propose that this strong wind prevents EUV radiation from reaching the disk
surface while the X-rays permeate the wind and irradiate the disk. We speculate
that at the time of the Spitzer observations, the wind was suppressed and EUV
radiation reached the disk. These observations confirm that the MIR neon
emission lines are sensitive to changes in high-energy radiation reaching the
disk surface. This highlights the [Ne III]-to-[Ne II] line flux ratio as a tool
to gauge the efficiency of disk photoevaporation in order to provide
constraints on the planet-formation timescale. However, multiwavelength
observations are crucial to interpret the observations and properly consider
the star-disk connection.Comment: Accepted to ApJ
Conditional generation of arbitrary multimode entangled states of light with linear optics
We propose a universal scheme for the probabilistic generation of an
arbitrary multimode entangled state of light with finite expansion in Fock
basis. The suggested setup involves passive linear optics, single photon
sources, strong coherent laser beams, and photodetectors with single-photon
resolution. The efficiency of this setup may be greatly enhanced if, in
addition, a quantum memory is available.Comment: 7 pages, 5 figure
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