Short-term variation in central corneal thick- ness and intraocular pressure using the Tono-Pachymeter NT530P (Tonopachy™)

Measurements of central corneal thickness (CCT) and intra-ocular pressure (IOP) are important for both diagnostic and therapeutic purposes. The aim of this study was to investigate the short-term variation and intra-subject repeatability of CCT and IOP measurements made with the Tono-Pachymeter NT530P (Tonopachy™). Fifty one consecutive automatic measurements of CCT and IOP were taken for the right eyes of 15 subjects (11 females and 4 males) aged 20 to 57 years (mean = 32.3 ± 13.5 years). The measured values (CCT and IOP) were compared against each other to establish the intra-subject repeatability and bias of each individual measurement with respect to the means, standard deviations and variances. Three different  statistical tests of normality: Kolmogorov-Smirnov (K-S),Lilliefors and Shapiro-Wilks (SW) tests suggested that most of the data was normally distributed,with a few exceptions. The inter-subject or overall mean values and standard deviations for the CCT and IOP samples were 528.2 ± 27.4 μm and 14.4 ±4.3 mmHg respectively. Although possible outliers increased the variability of the measurements of both parameters (CCT and IOP), the data generally showed good repeatability. The results of this study suggest that over short periods of time, the Tonopachy™ gives precise and repeatable measures of CCT and IOP. (S Afr Optom 2012 71(1) 12-21

REV-ERBα Participates in Circadian SREBP Signaling and Bile Acid Homeostasis

The nuclear receptor REV-ERBα shapes the daily activity profile of Sterol Response Element Binding Protein (SREBP) and thereby participates in the circadian control of cholesterol and bile acid synthesis in the liver