A case report of eosinophilic enterocolitis

A 13-year-old boy was admitted with complaints of abdominal pain and loose stools. Abdomen was distended. Laboratory tests on admission revealed neutrophilic leukocytosis and a peripheral smear done showed severe eosinophilia (33%) and leukocytosis. CT abdomen revealed ascites. Ascitic fluid tapping was done and 1.5 L of straw colored ascitic fluid drained. Ascitic fluid study was suggestive of high protein low SAAG ascites. The possibility of eosinophilic enterocolitis was considered. For confirmation endoscopy and sigmoidoscopy were done and a segmental biopsy was taken. Biopsy was suggestive of significant mucosal eosinophilia of duodenum, stomach, rectum, and eosinophilic abscess in the muscularis layer in the duodenum, stomach, and descending colon

Enteric fever resembling Malawi-Mozambique outbreak

A 47-year-old male with no known co-morbidities presented with hematochezia and multiple episodes of vomiting. He had a history of high-grade fever with chills, rigor, vomiting, and abdominal pain 3 weeks ago, for which he was treated with 5 days of IV antibiotics in another hospital. Examination revealed tremor, rigidity, hyperreflexia, bradykinesia, and hypophonic monotonous speech. Colonoscopy showed ileocolonic ulcers. Widal came positive. Treated as a case of Enteric fever with neurological complications such as parkinsonism, UMN signs, and gastrointestinal bleeding secondary to an ileal ulcer

Salmonella-related mycotic aneurysm: a rare but fatal condition

Salmonella species commonly causes gastrointestinal infection in humans. Occasionally they lead to serious complications such as mycotic aneurysms which are rare but potentially fatal. Mortality is high without timely intervention. The clinical presentation is variable and early diagnosis requires a high degree of clinical alertness. Here, we reported a case of mycotic aneurysm secondary to Salmonella enteritidis infection. The case highlights the need to evaluate all elderly patients with non-typhoid Salmonella bacteremia for possible endovascular infections

Indoor rowing machine with training data analysis system

Indoor rowing machines and training facilities for rowing are developed to simulate movements performed during the on-water rowing aiming to get results as close as possible to real rowing. The paper presents the novel indoor rowing machine equipped with loading measuring devices and software for training parameters recording and analysi

Indoor rowing machine with training data analysis system

Indoor rowing machines and training facilities for rowing are developed to simulate movements performed during the on-water rowing aiming to get results as close as possible to real rowing. The paper presents the novel indoor rowing machine equipped with loading measuring devices and software for training parameters recording and analysi

Socio-economic status of horse owners vis-a-vis horse feeding and management in Rajasthan

Aim: To study the socio-economic status, horse feeding and management adopted by horse owners of Rajasthan. Materials and Methods: Primary data was collected through specially structured proforma by personal interview method from the horse owners of Hanumangarh (50), Churu (42), Jhunjhunu (30) and Jalore (40) districts of Rajasthan, India. Results: The district (Churu and Jhunjhunu) is mostly rain fed, Hanumangarh is canal-irrigated whereas Jalore is tube well irrigated. Majority of respondents engaged in horse rearing were of other backward class (OBC) & general category. Literacy (%) among the horse owners was more than 80% in Hanumangarh and Jhunjhunu districts, whereas it was less than 50% in Churu and Jalore districts. Majority of the respondents were maintaining other livestock along with the horses. The average dry roughages provided were 4.82±0.22, 8.143±0.348, 5.267±0.69 and 6.105±0.196kg per horse in Hanumangarh, Churu, Jhunjhunu and Jalore, respectively. The average concentrate offered was 2.81±0.138, 2.452±0.145, 2.933±0.160 and 1.950±0.200kg per horse in Hanumangarh, Churu, Jhunjhunu and Jalore, respectively. It was observed that horse owners were providing green fodder, dry roughages and concentrate depending up on the availability/production of these items in that region. Majority of horse owners were allowing covering of estrus mares between 3rd and 5th day of estrus. Paucity of quality stallions for covering the mares was observed throughout the area surveyed. The respondents had to pay between Rs. 1100/- to 5100/- as covering fee with no guarantee of conception. Most of mares were rebred during foal heat and majority of the respondents were not aware about the symptoms of estrus mare. Vaccination, insurance and use of disinfectants were not adopted in the study indicating the least awareness among the horse owners about the importance of vaccination, insurance and disinfectants. Conclusion: Horses were being maintained for ceremonial purposes and breeding, their feeding in terms of fodder (green & dry) and concentrate were observed area specific and were fulfilling the minimum nutrient requirements. There was paucity of true to breed stallions in the areas studied. [Vet World 2013; 6(8.000): 470-475

Combination chemotherapy with or without s.c. IL-2 and IFN-α: results of a prospectively randomized trial of the Cooperative Advanced Malignant Melanoma Chemoimmunotherapy Group (ACIMM)

The purpose of this randomized trial was to evaluate the efficacy of combination chemoimmunotherapy compared with chemotherapy alone. A total of 124 patients were randomized to receive intravenous cisplatin (35 mg m−2, days 1–3), carmustine (150 mg m−2, day 1, cycles 1 and 3 only), dacarbacine (220 mg m−2, days 1–3) and oral tamoxifen (20 mg m−2, daily) in combination with (n=64) or without (n=60) sequential subcutaneous IL-2 and IFN-α. In those patients who received sequential immunotherapy, each cycle of chemotherapy was followed by outpatient s.c. IL-2 (10×106 IU m−2, days 3–5, week 4; 5×106 IU m−2, days 1, 3, 5, week 5) and s.c. IFN-α (5×106 IU m−2, day 1, week 4; days 1, 3, 5, week 5). The overall response rate of patients treated with the combination of chemotherapy and IL-2/IFN-α was 34.3% with seven complete responses (10.9%) and 15 partial responses (23.4%). In patients treated with chemotherapy, only, the overall response rate was 29.9% with eight complete responses (13.3%) and 10 partial responses (16.6%). There was no significant difference in median progression free survival (0 months vs 4 months) and in median overall survival (12 months vs 13 months) for combined chemoimmunotherapy and for chemotherapy, respectively

Some reproductive parameters of Zanskari mares reared in an organized farm under tropical climate

The present study was undertaken to record the data on duration of estrus, estrus cycle length, size of the follicle at ovulation, period of gestation and estrus after foaling (foal heat) in respect of Zanskari mares for 4 consecutive breeding seasons (2010–2014). The mares were closely monitored with transrectal ultrasonography for their follicle size variation and to determine size of the follicle at ovulation. The mares were inseminated with frozen thawed semen from Zanskari stallions. This is the first time ever that Zanskari stallion semen was cryopreserved successfully and viable foals were produced by using frozen semen via artificial insemination. The reproductive parameters of the mares of Zanskari breed in India are poorly investigated and thus no reports are available on reproductive characteristics of Zanskari breed till today in the literature. Our results can be useful as a ready reference for some of the reproductive characteristics and traits of Zanskari breed as well as indigenous horses reared under tropical region. The reproductive parameters analysed in the present study are fitting within the characteristics of the other Indian horse breeds reared under this region and the differences may be caused by breed effect and other environmental factors

Tumor markers in breast cancer - European Group on Tumor Markers recommendations

Recommendations are presented for the routine clinical use of serum and tissue-based markers in the diagnosis and management of patients with breast cancer. Their low sensitivity and specificity preclude the use of serum markers such as the MUC-1 mucin glycoproteins ( CA 15.3, BR 27.29) and carcinoembryonic antigen in the diagnosis of early breast cancer. However, serial measurement of these markers can result in the early detection of recurrent disease as well as indicate the efficacy of therapy. Of the tissue-based markers, measurement of estrogen and progesterone receptors is mandatory in the selection of patients for treatment with hormone therapy, while HER-2 is essential in selecting patients with advanced breast cancer for treatment with Herceptin ( trastuzumab). Urokinase plasminogen activator and plasminogen activator inhibitor 1 are recently validated prognostic markers for lymph node-negative breast cancer patients and thus may be of value in selecting node-negative patients that do not require adjuvant chemotherapy. Copyright (C) 2005 S. Karger AG, Basel

Development and characterization of CD22-targeted pegylated-liposomal doxorubicin (IL-PLD)

Non-Hodgkin’s lymphoma (NHL) is the sixth most common cause of cancer deaths in the U.S. Most NHLs initially respond well to chemotherapy, but relapse is common and treatment is often limited due to the toxicity of chemotherapeutic agents. Pegylated-liposomal doxorubicin (PLD, Ben Venue Laboratories, Inc), a produces less myelotoxicity than non-liposomal (NL) doxorubicin. To further enhance efficacy and NHL targeting and to decrease toxicity, we conjugated an anti-CD22 monoclonal antibody (HB22.7) to the surface of PLD, thereby creating CD22-targeted immunoliposomal PLD (IL-PLD). HB22.7 was successfully conjugated to PLD and the resulting IL-PLD exhibits specific binding to CD22-expressing cells as assessed by immunofluorescence staining. IL-PLD exhibits more cytotoxicity than PLD in CD22 positive cell lines but does not increase killing of CD22 negative cells. The IC50 of IL-PLD is 3.1 to 5.4 times lower than that of PLD in CD22+ cell lines while the IC50 of IL-PLD is equal to that of PLD in CD22- cells. Furthermore, IL-PLD remained bound to the CD22+ cells after washing and continued to exert cytotoxic effects, while PLD and NL- doxorubicin could easily be washed from these cells