Photometry of Proxima Centauri and Barnard's Star Using HST Fine Guidance Sensor 3: A Search for Periodic Variations

We have observed Proxima Centauri and Barnard's Star with Hubble Space Telescope Fine Guidance Sensor 3. Proxima Centauri exhibits small-amplitude, periodic photometric variations. Once several sources of systematic photometric error are corrected, we obtain 2 milli-magnitude internal photometric precision. We identify two distinct behavior modes over the past four years: higher amplitude, longer period; smaller amplitude, shorter period. Within the errors one period (P ~ 83d) is twice the other. Barnard's Star shows very weak evidence for periodicity on a timescale of approximately 130 days. If we interpret these periodic phenomena as rotational modulation of star spots, we identify three discrete spots on Proxima Cen and possibly one spot on Barnard's Star. We find that the disturbances change significantly on time scales as short as one rotation period.Comment: 39 pages, 17 figure

Interferometric Astrometry of Proxima Centauri and Barnard's Star Using Hubble Space Telescope Fine Guidance Sensor 3: Detection Limits for sub-Stellar Companions

We report on a sub-stellar companion search utilizing interferometric fringe-tracking astrometry acquired with Fine Guidance Sensor 3 (FGS 3) on the Hubble Space Telescope. Our targets were Proxima Centauri and Barnard's Star. We obtain absolute parallax values for Proxima Cen pi_{abs} = 0.7687 arcsecond and for Barnard's Star pi_{abs} = 0.5454 arcsecond. Once low-amplitude instrumental systematic errors are identified and removed, our companion detection sensitivity is less than or equal to one Jupiter mass for periods longer than 60 days for Proxima Cen. Between the astrometry and the radial velocity results we exclude all companions with M > 0.8M_{Jup} for the range of periods 1 < P < 1000 days. For Barnard's Star our companion detection sensitivity is less than or equal to one Jupiter mass for periods long er than 150 days. Our null results for Barnard's Star are consistent with those of Gatewood (1995).Comment: 35 pages, 13 figures, to appear in August 1999 A

The Distance To The Hyades Cluster Based On Hubble Space Telescope Fine Guidance Sensor Parallaxes

Trigonometric parallax observations made with the Hubble Space Telescope (HST) Fine Guidance Sensor (FGS) 3 of seven Hyades members in six fields of view have been analyzed along with their proper motions to determine the distance to the cluster. Knowledge of the convergent point and mean proper motion of the Hyades is critical to the derivation of the distance to the center of the cluster. Depending on the choice of the proper-motion system, the derived cluster center distance varies by 9%. Adopting a reference distance of 46.1 pc or m - M = 3.32, which is derived from the ground-based parallaxes in the General Catalogue of Trigonometric Stellar Parallaxes (1995 edition), the FK5/PPM proper-motion system yields a distance 4% larger, while the Hanson system yields a distance 2% smaller. The HST FGS parallaxes reported here yield either a 14% or 5% larger distance, depending on the choice of the proper-motion system. Orbital parallaxes (Torres et al.) yield an average distance 4% larger than the reference distance. The variation in the distance derived from the HST data illustrates the importance of the proper-motion system and the individual proper motions to the derivation of the distance to the Hyades center; therefore, a full utilization of the HST FGS parallaxes awaits the establishment of an accurate and consistent proper-motion system.NASA HST GTO, HF-1042.01-93A, HF-1046.01-93A, NAS526555Astronom

Astrometry with Hubble Space Telescope: A Parallax of the Fundamental Distance Calibrator RR Lyrae

We present an absolute parallax and relative proper motion for the fundamental distance scale calibrator, RR Lyr. We obtain these with astrometric data from FGS 3, a white-light interferometer on HST. We find $\pi_{abs} = 3.82 \pm 0.2$ mas. Spectral classifications and VRIJHKT$_2$M and DDO51 photometry of the astrometric reference frame surrounding RR Lyr indicate that field extinction is low along this line of sight. We estimate =0.07\pm0.03 for these reference stars. The extinction suffered by RR Lyr becomes one of the dominant contributors to the uncertainty in its absolute magnitude. Adopting the average field absorption, =0.07 \pm 0.03, we obtain M_V^{RR} = 0.61 ^{-0.11}_{+0.10}. This provides a distance modulus for the LMC, m-M = 18.38 - 18.53^{-0.11}_{+0.10} with the average extinction-corrected magnitude of RR Lyr variables in the LMC, , remaining a significant uncertainty. We compare this result to more than 80 other determinations of the distance modulus of the LMC.Comment: Several typos corrected. To appear in The Astronomical Journal, January 200

School-based high-intensity interval training programs in children and adolescents: A systematic review and meta-analysis

Purpose1) To investigate the effectiveness of school-based high-intensity interval training (HIIT) interventions in promoting health outcomes of children and adolescents compared with either a control group or other exercise modality; and 2) to explore the intervention characteristics and process outcomes of published school-based HIIT interventions.MethodsWe searched Medline, Embase, CINAHL, SPORTDiscus, and Web of Science from inception until 31 March 2021. Studies were eligible if 1) participants aged 5–17 years old; 2) a HIIT intervention within a school setting ≥ 2 weeks duration; 3) a control or comparative exercise group; 4) health-related, cognitive, physical activity, nutrition, or program evaluation outcomes; and 5) original research published in English. We conducted meta-analyses between HIIT and control groups for all outcomes with ≥ 4 studies and meta-regressions for all outcomes with ≥ 10 studies. We narratively synthesised results between HIIT and comparative exercise groups.ResultsFifty-four papers met eligibility criteria, encompassing 42 unique studies (35 randomised controlled trials; 36 with a high risk of bias). Meta-analyses indicated significant improvements in waist circumference (mean difference (MD) = -2.5cm), body fat percentage (MD = -1.7%), body mass index (standardised mean difference (SMD) = -1.0), cardiorespiratory fitness (SMD = +1.0), resting heart rate (MD = -5bpm), homeostatic model assessment–insulin resistance (MD = -0.7), and low-density lipoprotein cholesterol (SMD = -0.9) for HIIT compared to the control group. Our narrative synthesis indicated mixed findings between HIIT and other comparative exercise groups.ConclusionSchool-based HIIT is effective for improving several health outcomes. Future research should address the paucity of information on physical activity and nutrition outcomes and focus on the integration and long-term effectiveness of HIIT interventions within school settings

Astrometry with The \u3cem\u3eHubble Space Telescope\u3c/em\u3e: A Parallax of the Central Star of the Planetary Nebula NGC 6853

We present an absolute parallax and relative proper motion for the central star of the planetary nebula NGC 6853 (the Dumbbell). We obtain these with astrometric data from the Fine Guidance Sensor 3, a white-light interferometer on the Hubble Space Telescope. Spectral classifications and VRIJHKT2M and DDO51 photometry of the stars making up the astrometric reference frame provide spectrophotometric estimates of their absolute parallaxes. Introducing these into our model as observations with error, we find πabs = 2.10 ± 0.48 mas for the DAO central star of NGC 6853. A weighted average with a previous ground-based USNO determination yields πabs = 2.40 ± 0.32. We assume that the extinction suffered by the reference stars nearest (in angular separation and distance) to the central star is the same as for the central star. Correcting for color differences, we find AV = 0.30 ± 0.06 for the central star, hence, an absolute magnitude MV = 5.48. A recent determination of the central star effective temperature aided in estimating the central star radius, R* = 0.055 ± 0.02 R⊙, a star that may be descending to the white dwarf cooling track

Genetic variation at MECOM, TERT, JAK2 and HBS1L-MYB predisposes to myeloproliferative neoplasms

Clonal proliferation in myeloproliferative neoplasms (MPN) is driven by somatic mutations in JAK2, CALR or MPL, but the contribution of inherited factors is poorly characterized. Using a three-stage genome-wide association study of 3,437 MPN cases and 10,083 controls, we identify two SNPs with genome-wide significance in JAK2V617F-negative MPN: rs12339666 (JAK2; meta-analysis P=1.27 × 10−10) and rs2201862 (MECOM; meta-analysis P=1.96 × 10−9). Two additional SNPs, rs2736100 (TERT) and rs9376092 (HBS1L/MYB), achieve genome-wide significance when including JAK2V617F-positive cases. rs9376092 has a stronger effect in JAK2V617F-negative cases with CALR and/or MPL mutations (Breslow–Day P=4.5 × 10−7), whereas in JAK2V617F-positive cases rs9376092 associates with essential thrombocythemia (ET) rather than polycythemia vera (allelic χ2 P=7.3 × 10−7). Reduced MYB expression, previously linked to development of an ET-like disease in model systems, associates with rs9376092 in normal myeloid cells. These findings demonstrate that multiple germline variants predispose to MPN and link constitutional differences in MYB expression to disease phenotype

Precise Masses for Wolf 1062 AB from Hubble Space Telescope Interferometric Astrometry and McDonald Observatory Radial Velocities

We present an analysis of astrometric data from FGS 3, a white-light interferometer on {\it HST}, and of radial velocity data from two ground-based campaigns. We model the astrometric and radial velocity measurements simultaneously to obtain parallax, proper motion and component masses for Wolf 1062 = Gl 748 AB (M3.5V). To derive the mass fraction, we relate FGS 3 fringe scanning observations of the science target to a reference frame provided by fringe tracking observations of a surrounding star field. We obtain an absolute parallax $\pi_{abs} = 98.0 \pm 0.4$ milliseconds of arc, yielding {\cal M}_A = 0.379 \pm 0.005{\cal M}_{\sun} and {\cal M}_B= 0.192 \pm 0.003 {\cal M}_{\sun}, high quality component masses with errors of only 1.5%.Comment: 13 pages, 7 figures. To appear in AJ March 200