1,149 research outputs found

    Cells of the synovium in rheumatoid arthritis. Macrophages

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    The multitude and abundance of macrophage-derived mediators in rheumatoid arthritis and their paracrine/autocrine effects identify macrophages as local and systemic amplifiers of disease. Although uncovering the etiology of rheumatoid arthritis remains the ultimate means to silence the pathogenetic process, efforts in understanding how activated macrophages influence disease have led to optimization strategies to selectively target macrophages by agents tailored to specific features of macrophage activation. This approach has two advantages: (a) striking the cell population that mediates/amplifies most of the irreversible tissue destruction and (b) sparing other cells that have no (or only marginal) effects on joint damage

    Improved Prediction of Atmospheric Heating and Cooling Rates

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    The demands of accurate predictions of radiative transfer for climate applications are well-documented. While much effort is being devoted to evaluating the accuracy of the GCM radiative transfer schemes, the problem of developing accurate, computationally efficient schemes for climate models still remains. This paper discusses our efforts in developing accurate and fast computational methods for global and regional climate models

    Comparisons of downwelling radiation to model predictions based on groundbased measurements during FIRE 1991

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    Surface radiation measurements and simultaneous ground-based measurements of the atmosphere during the FIRE'91 cirrus field experiment provided an opportunity to identify crucial measurements and parameterization deficiencies in current cloud-radiation models. Comparisons between measured and calculated broadband surface fluxes with only a small data subset already reveal these needs: accurate humidity and aerosol vertical profiles for clear cases, accurate vertical extinction profiles and dimensions for clouds, and understanding of the (solar) scattering properties of cirrus
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