4,417 research outputs found
Plasmon Evolution and Charge-Density Wave Suppression in Potassium Intercalated Tantalum Diselenide
We have investigated the influence of potassium intercalation on the
formation of the charge-density wave (CDW) instability in 2H-tantalum
diselenide by means of Electron Energy-Loss Spectroscopy and density functional
theory. Our observations are consistent with a filling of the conduction band
as indicated by a substantial decrease of the plasma frequency in experiment
and theory. In addition, elastic scattering clearly points to a destruction of
the CDW upon intercalation as can be seen by a vanishing of the corresponding
superstructures. This is accompanied by a new superstructure, which can be
attributed to the intercalated potassium. Based on the behavior of the c-axis
upon intercalation we argue in favor of interlayer-sites for the alkali-metal
and that the lattice remains in the 2H-modification
Human endogenous retrovirus K106 (HERV-K106) was infectious after the emergence of anatomically modern humans.
HERV-K113 and HERV-K115 have been considered to be among the youngest HERVs because they are the only known full-length proviruses that are insertionally polymorphic and maintain the open reading frames of their coding genes. However, recent data suggest that HERV-K113 is at least 800,000 years old, and HERV-K115 even older. A systematic study of HERV-K HML2 members to identify HERVs that may have infected the human genome in the more recent evolutionary past is lacking. Therefore, we sought to determine how recently HERVs were exogenous and infectious by examining sequence variation in the long terminal repeat (LTR) regions of all full-length HERV-K loci. We used the traditional method of inter-LTR comparison to analyze all full length HERV-Ks and determined that two insertions, HERV-K106 and HERV-K116 have no differences between their 5' and 3' LTR sequences, suggesting that these insertions were endogenized in the recent evolutionary past. Among these insertions with no sequence differences between their LTR regions, HERV-K106 had the most intact viral sequence structure. Coalescent analysis of HERV-K106 3' LTR sequences representing 51 ethnically diverse individuals suggests that HERV-K106 integrated into the human germ line approximately 150,000 years ago, after the emergence of anatomically modern humans
Recovery of Hippocampal-Dependent Learning Despite Blunting Reactive Adult Neurogenesis after Alcohol Dependence
Background:
The excessive alcohol drinking that occurs in alcohol use disorder (AUD) causes neurodegeneration in regions such as the hippocampus, though recovery may occur after a period of abstinence. Mechanisms of recovery are not clear, though reactive neurogenesis has been observed in the hippocampal dentate gyrus following alcohol dependence and correlates to recovery of granule cell number.
Objective:
We investigated the role of neurons born during reactive neurogenesis in the recovery of hippocampal learning behavior after 4-day binge alcohol exposure, a model of an AUD. We hypothesized that reducing reactive neurogenesis would impair functional recovery.
Methods:
Adult male rats were subjected to 4-day binge alcohol exposure and two approaches were tested to blunt reactive adult neurogenesis, acute doses of alcohol or the chemotherapy drug, temozolomide (TMZ).
Results:
Acute 5âg/kg doses of EtOH gavaged T6 and T7 days post binge did not inhibit significantly the number of Bromodeoxyuridine-positive (BrdU+) proliferating cells in EtOH animals receiving 5âg/kg EtOH versus controls. A single cycle of TMZ inhibited reactive proliferation (BrdU+ cells) and neurogenesis (NeuroD+ cells) to that of controls. However, despite this blunting of reactive neurogenesis to basal levels, EtOH-TMZ rats were not impaired in their recovery of acquisition of the Morris water maze (MWM), learning similarly to all other groups 35 days after 4-day binge exposure.
Conclusions:
These studies show that TMZ is effective in decreasing reactive proliferation/neurogenesis following 4-day binge EtOH exposure, and baseline levels of adult neurogenesis are sufficient to allow recovery of hippocampal function
Shifting a Quantum Wire through a Disordered Crystal: Observation of Conductance Fluctuations in Real Space
A quantum wire is spatially displaced by suitable electric fields with
respect to the scatterers inside a semiconductor crystal. As a function of the
wire position, the low-temperature resistance shows reproducible fluctuations.
Their characteristic temperature scale is a few hundred millikelvin, indicating
a phase-coherent effect. Each fluctuation corresponds to a single scatterer
entering or leaving the wire. This way, scattering centers can be counted one
by one.Comment: 4 pages, 3 figure
Active pixel sensor having intra-pixel charge transfer with analog-to-digital converter
An imaging device formed as a monolithic complementary metal oxide semiconductor Integrated circuit in an industry standard complementary metal oxide semiconductor process, the integrated circuit including a focal plane array of pixel cells, each one of the cells including a photogate overlying the substrate for accumulating photo-generated charge in an underlying portion of the substrate, a readout circuit including at least an output field effect transistor formed in the substrate, and a charge coupled device section formed on the substrate adjacent the photogate having a sensing node connected to the output transistor and at least one charge coupled device stage for transferring charge from the underlying portion of the substrate to the sensing node and an analog-to-digital converter formed in the substrate connected to the output of the readout circuit
Active pixel sensor having intra-pixel charge transfer with analog-to-digital converter
An imaging device formed as a monolithic complementary metal oxide semiconductor integrated circuit in an industry standard complementary metal oxide semiconductor process, the integrated circuit including a focal plane array of pixel cells, each one of the cells including a photogate overlying the substrate for accumulating photo-generated charge in an underlying portion of the substrate, a readout circuit including at least an output field effect transistor formed in the substrate, and a charge coupled device section formed on the substrate adjacent the photogate having a sensing node connected to the output transistor and at least one charge coupled device stage for transferring charge from the underlying portion of the substrate to the sensing node and an analog-to-digital converter formed in the substrate connected to the output of the readout circuit
Embedding language across the university and through the curriculum: implementing the EEL project
New magnetic dipole transition of the oxygen molecule: BÊč³ΠgâXâ³Σgâ»(0,0)
Through the use of isotopically pure gas at a temperature of 77 K, a weak photoabsorption band of Âčâ¶Oâ is found near 1856 Ă
, underlying the stronger SchumannâRunge (SR) band B³ΣâuâX³Σâg(8,0). The location, structure, and intensity of this new band are consistent with expectation for the magnetic dipole transitionBâČâ³ΠgâX³Σâg(0,0), where the designation BâČ is chosen to represent the IIâ³Πg valence state. This electronic transition contributes to the âexcess absorptionâ underlying the SR bands [B. R. Lewis, S. T. Gibson, and E. H. Roberts, J. Chem. Phys. 115, 245 (2001)]
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