An In Vivo Study Of A Locally-Manufactured Hydroxyapatite -Based Material As Bone Replacement Material.

Synthetic HA has excellent biocompatibility, but it has limited application due to its low toughness and flexural strength. In order to improve the mechanical properties (impact resistance, and tensile strength), metals and other elements were added to HA

Respiratory dysfunction in myotonic dystrophy type 1: A systematic review

Myotonic dystrophy type 1 (DM1) is one of the most common muscular dystrophies in adults. This review summarises the current literature regarding the natural history of respiratory dysfunction in DM1, the role of central respiratory drive and peripheral respiratory muscle involvement and its significance in respiratory function, and investigates the relationship between genetics (CTG repeat length) and respiratory dysfunction. The review included all articles that reported spirometry on 10 or more myotonic dystrophy patients. The final review included 55 articles between 1964 and 2017. The major conclusions of this review were (1) confirmation of the current consensus that respiratory dysfunction, predominantly a restrictive ventilatory pattern, is common in myotonic dystrophy and is associated with alveolar hypoventilation, chronic hypercapnia, and sleep disturbance in the form of sleep apnoea and sleep related disordered breathing; (2) contrary to commonly held belief, there is no consensus in the literature regarding the relationship between CTG repeat length and severity of respiratory dysfunction and a relationship has not been established; (3) the natural history and time-course of respiratory functional decline is very poorly understood in the current literature; (4) there is a consensus that there is a significant involvement of central respiratory drive in this alveolar hypoventilation however the current literature does not identify the mechanism for this

ASSIMILATING GEOSPATIAL METAMODEL AND INVENTORY MAPPING FOR NON-STRUCTURAL MITIGATION OF LANDSLIDE

In Malaysia, issues related to disaster management are always given attention in society and by the responsible parties. However, in general, citizen do not think of the consequential impact of disaster due to less of knowledge regarding the early phase in disaster management. Therefore, citizen in those areas will be more vulnerable to landslide as the citizen face difficulties in identifying specific areas with the tendency of landslides. This paper presents a geospatial metamodel approach for non-structural mitigation of landslide using data from airborne LiDAR and aerial photograph. Disaster management metamodel with geospatial element combines activity for managing disaster along with geospatial database that makes it handy for appreciating the metamodel. On the other hand, the digital terrain model (DTM) from LiDAR and aerial photograph is required to produce landslide inventory mapping. The case study area is located in Kundasang, Sabah, where landslides occur frequently. In order to get better visual in identifying landslides in the study area, three types of data are required to carry out image interpretation. The three types of data are hillshade, topographic openness and colour composite. The result of the landslide inventory map shows that there are five types of landslide, which is debris flow, debris fall, mud flow, deep-seated landslide and shallow landslide. Finally, the result of landslide inventory map will be integrated into the developed metamodel for presentation to the users. This landslide inventory map is used as a non-structural mitigation step in one of disaster management phases that is suitable to prepare and use in mitigating the landslide hazard impact

Effect of Surface Hardness on Joint Contact Forces during Barefoot Running: A Pilot Study

This paper presents an experimental pilot study on the effect of different surface hardness to the joint contact force during barefoot running. Peak joint contact forces during the stance phase of a male subject that running barefoot on three types of surface with different hardness level (concrete, artificial grass and rubber) were investigated experimentally. Differences in peak joint contact force at the ankle, medial tibiofemoral, lateral tibiofemoral, hip and patellofemoral due to surface effects were analysed using Freebody (Version2.1) software. The result showed that the pattern of peak joint contact force was similar for ankle with medial tibiofemoral and hip with lateral patellofemoral. The joint contact force was varied in the varying of the surface hardness. The correlation between various surface hardness and joint contact force was found at the ankle and medial tibiofemoral joint. However, the findings of this pilot study provide the insight into the method and approach selected for the experiment be suitable for an actual experiment for more subjects

GEOSPATIAL APPROACH FOR LANDSLIDE ACTIVITY ASSESSMENT AND MAPPING BASED ON VEGETATION ANOMALIES

Remote sensing has been widely used for landslide inventory mapping and monitoring. Landslide activity is one of the important parameters for landslide inventory and it can be strongly related to vegetation anomalies. Previous studies have shown that remotely sensed data can be used to obtain detailed vegetation characteristics at various scales and condition. However, only few studies of utilizing vegetation characteristics anomalies as a bio-indicator for landslide activity in tropical area. This study introduces a method that utilizes vegetation anomalies extracted using remote sensing data as a bio-indicator for landslide activity analysis and mapping. A high-density airborne LiDAR, aerial photo and satellite imagery were captured over the landslide prone area along Mesilau River in Kundasang, Sabah. Remote sensing data used in characterizing vegetation into several classes of height, density, types and structure in a tectonically active region along with vegetation indices. About 13 vegetation anomalies were derived from remotely sensed data. There were about 14 scenarios were modeled by focusing in 2 landslide depth, 3 main landslide types with 3 landslide activities by using statistical approach. All scenarios show that more than 65% of the landslides are captured within 70% of the probability model indicating high model efficiency. The predictive model rate curve also shows that more than 45% of the independent landslides can be predicted within 30% of the probability model. This study provides a better understanding of remote sensing data in extracting and characterizing vegetation anomalies induced by hillslope geomorphology processes in a tectonically active region in Malaysia

Seatbelt use and risk of major injuries sustained by vehicle occupants during motor-vehicle crashes: A systematic review and meta-analysis of cohort studies

BackgroundIn 2004, a World Health Report on road safety called for enforcement of measures such as seatbelt use, effective at minimizing morbidity and mortality caused by road traffic accidents. However, injuries caused by seatbelt use have also been described. Over a decade after publication of the World Health Report on road safety, this study sought to investigate the relationship between seatbelt use and major injuries in belted compared to unbelted passengers.MethodsCohort studies published in English language from 2005 to 2018 were retrieved from seven databases. Critical appraisal of studies was carried out using the Scottish Intercollegiate Guidelines Network (SIGN) checklist. Pooled risk of major injuries was assessed using the random effects meta-analytic model. Heterogeneity was quantified using I-squared and Tau-squared statistics. Funnel plots and Egger's test were used to investigate publication bias. This review is registered in PROSPERO (CRD42015020309).ResultsEleven studies, all carried out in developed countries were included. Overall, the risk of any major injury was significantly lower in belted passengers compared to unbelted passengers (RR 0.47; 95%CI, 0.29 to 0.80; I-2=99.7; P=0.000). When analysed by crash types, belt use significantly reduced the risk of any injury (RR 0.35; 95%CI, 0.24 to 0.52). Seatbelt use reduces the risk of facial injuries (RR=0.56, 95% CI=0.37 to 0.84), abdominal injuries (RR=0.87; 95% CI=0.78 to 0.98) and, spinal injuries (RR=0.56, 95% CI=0.37 to 0.84). However, we found no statistically significant difference in risk of head injuries (RR=0.49; 95% CI=0.22 to 1.08), neck injuries (RR=0.69: 95%CI 0.07 to 6.44), thoracic injuries (RR 0.96, 95%CI, 0.74 to 1.24), upper limb injuries (RR=1.05, 95%CI 0.83 to 1.34) and lower limb injuries (RR=0.77, 95%CI 0.58 to 1.04) between belted and non-belted passengers.ConclusionIn sum, the risk of most major road traffic injuries is lower in seatbelt users. Findings were inconclusive regarding seatbelt use and susceptibility to thoracic, head and neck injuries during road traffic accidents. Awareness should be raised about the dangers of inadequate seatbelt use. Future research should aim to assess the effects of seatbelt use on major injuries by crash type

Factors affecting commencement and cessation of smoking behaviour in Malaysian adults

<p>Abstract</p> <p>Background</p> <p>Tobacco consumption peak in developed countries has passed, however, it is on the increase in many developing countries. Apart from cigarettes, consumption of local hand-rolled cigarettes such as <it>bidi </it>and <it>rokok daun </it>are prevalent in specific communities. Although factors associated with smoking initiation and cessation has been investigated elsewhere, the only available data for Malaysia is on prevalence. This study aims to investigate factors associated with smoking initiation and cessation which is imperative in designing intervention programs.</p> <p>Methods</p> <p>Data were collected from 11,697 adults by trained recording clerks on sociodemographic characteristics, practice of other risk habit and details of smoking such as type, duration and frequency. Smoking commencement and cessation were analyzed using the Kaplan-Meier estimates and log-rank tests. Univariate and multivariate Cox proportional hazard regression models were used to calculate the hazard rate ratios.</p> <p>Results</p> <p>Males had a much higher prevalence of the habit (61.7%) as compared to females (5.8%). Cessation was found to be most common among the Chinese and those regularly consuming alcoholic beverages. Kaplan-Meier plot shows that although males are more likely to start smoking, females are found to be less likely to stop. History of betel quid chewing and alcohol consumption significantly increase the likelihood of commencement (p < 0.0001), while cessation was least likely among Indians, current quid chewers and kretek users (p < 0.01).</p> <p>Conclusions</p> <p>Gender, ethnicity, history of quid chewing and alcohol consumption have been found to be important factors in smoking commencement; while ethnicity, betel quid chewing and type of tobacco smoked influences cessation.</p