1,133 research outputs found
Multivalent Recognition of Peptides by Modular Self-Assembled Receptors
Developing nontraditional approaches to the synthesis and characterization of multivalent compounds is critical to our efforts to study and interface with biological systems and to build new noncovalent materials. This paper demonstrates a biomimetic approach to the construction of discrete, modular, multivalent receptors via molecular self-assembly in aqueous solution. Scaffolds presenting 1â3 viologen groups recruit a respective 1â3 copies of the synthetic host, cucurbit[8]uril, in a noncooperative manner and with a consistent equilibrium association constant (Ka) value of 2 Ă 106 Mâ1 per binding site. The assembled mono-, di-, and trivalent receptors bind to their cognate target peptides containing 1â3 Trp residues with Ka values in the range 1.7 Ă 104â4.7 Ă 106 Mâ1 and in predetermined mono- or multivalent binding modes with 31â280-fold enhancements in affinity and additive enthalpies due to multivalency. The extent of valency was determined directly by measuring the visible charge-transfer absorptivity due to the viologenâindole pair. The predictable behavior of this system and its ease of synthesis and analysis make it well suited to serve as a model for multivalent binding and for the multivalent recognition of peptides by design
Life table analysis of Diaphorina citri (Hemiptera: Psyllidae) infesting sweet orange (Citrus sinensis) in SĂŁo Paulo
An ecological life table for eggs and nymphs of Diaphorina citri Kuwayama (Hemiptera:
Psyllidae) was constructed with data obtained from orange orchards (Citrus sinensis Osbeck) in 2 regions of the State of SĂŁo Paulo, over 4 generations in the period from XI-2006
to V-2007, comprising spring, summer, and fall seasons. Young growing shoots with D. citri
eggs present were identifed, and live individuals were counted until adult emergence. No
predatory arthropods were observed in association with D. citri eggs and nymphs during
the study. The mean parasitism of fourth- and ffth-instar nymphs by Tamarixia radiata
Waterston (Hymenoptera: Eulophidae) was 2.3%. The durations of the eggâadult period
were similar among the 4 generations, ranging from 18.0 to 24.7 d (at mean temperatures
ranging from 21.6 to 26.0 °C) and followed the temperature requirement models obtained
in the laboratory for D. citri. However, survival from the egg to the adult stage for the same
period varied considerably from 1.7 to 21.4%; the highest mortalities were observed in the
egg and small nymphal (frst- to thirdinstar) stages, which were considered to be key phases
for population growth of the pest.Uma tabela de vida ecolĂłgica foi construĂda para ovos e ninfas de Diaphorina citri Kuwayama (Hemiptera: Psyllidae) com dados obtidos em pomares de laranja (Citrus sinensis Osbeck) em 2 regiĂ”es do estado de SĂŁo Paulo, com 4 geraçÔes, no perĂodo de novembro de 2006
a maio de 2007, compreendendo as estaçÔes de primavera, verão e outono. Ramos jovens
em crescimento com a presença de ovos de D. citri foram identificados e os indivĂduos vivos
foram contados atĂ© a emergĂȘncia dos adultos. Nenhum predador foi observado associado a
ovos e ninfas de D. citri durante o estudo. A taxa média de parasitismo de ninfas de quarto
e quinto Ănstares por Tamarixia radiata Waterson (Hymenoptera: Eulophidae) foi de 2.3%.
A duração do perĂodo de ovo a adulto foi semelhante entre as quatro geraçÔes, variando de
18.0 a 24.7 dias (com temperaturas médias de 21.6 a 26.0 °C) e seguiram os modelos de
exigencias térmicas obtidas em laboratório para D. citri. Todavia, a sobrevivencia de ovo
atĂ© o estĂĄgio adulto variou consideravelmente para o mesmo perĂodo, de 1.7 a 21.4%, sendo
que as maiores mortalidades foram observadas nos estĂĄgios de ovos e ninfas pequenas (de
primeiro a terceiro Ănstares), as quais foram consideradas fases chaves para o crescimento
populacional desta praga.info:eu-repo/semantics/publishedVersio
âEngage the Worldâ: examining conflicts of engagement in public museums
Public engagement has become a central theme in the mission statements of many cultural institutions, and in scholarly research into museums and heritage. Engagement has emerged as the go-to-it-word for generating, improving or repairing relations between museums and society at large. But engagement is frequently an unexamined term that might embed assumptions and ignore power relationships. This article describes and examines the implications of conflicting and misleading uses of âengagementâ in relation to institutional dealings with contested questions about culture and heritage. It considers the development of an exhibition on the Dead Sea Scrolls by the Royal Ontario Museum, Toronto in 2009 within the new institutional goal to âEngage the Worldâ. The chapter analyses the motivations, processes and decisions deployed by management and staff to âEngage the Worldâ, and the degree to which the museum was able to re-think its strategies of public engagement, especially in relation to subjects,issues and publics that were more controversial in nature
Elastic scattering and breakup of 17^F at 10 MeV/nucleon
Angular distributions of fluorine and oxygen produced from 170 MeV 17^F
incident on 208^Pb were measured. The elastic scattering data are in good
agreement with optical model calculations using a double-folding potential and
parameters similar to those obtained from 16^O+208^Pb. A large yield of oxygen
was observed near \theta_lab=36 deg. It is reproduced fairly well by a
calculation of the (17^F,16^O) breakup, which is dominated by one-proton
stripping reactions. The discrepancy between our previous coincidence
measurement and theoretical predictions was resolved by including core
absorption in the present calculation.Comment: 9 pages, 5 figure
Collective Flow from the Intranuclear Cascade Model
The phenomenon of collective flow in relativistic heavy ion collisions is
studied using the hadronic cascade model ARC. Direct comparison is made to data
gathered at the Bevalac, for Au+Au at GeV/c. In contrast to the
standard lore about the cascade model, collective flow is well described
quantitatively without the need for explicit mean field terms to simulate the
nuclear equation of state. Pion collective flow is in the opposite direction to
nucleon flow as is that of anti-nucleons and other produced particles. Pion and
nucleon flow are predicted at AGS energies also, where, in light of the higher
baryon densities achieved, we speculate that equation of state effects may be
observable.Comment: 9 pages, 2 figures include
Looking backward, looking forward: the city region of the mid-21st century
Emerging as a serious tool of analysis in the United States around 1950, the city region concept was increasingly applied in a European context after 1980. Since 2000, it has evolved further with recognition of the polycentric mega-city region, first recognised in Eastern Asia but now seen as an emerging urban form both in Europe and the United States. The paper speculates on the main changes that may impact on the growth and development of such complex urban regions in the first half of the 21st century, concluding that achieving the goal of polycentric urban development may prove more complex than at first it may seem
Delays Associated with Elementary Processes in Nuclear Reaction Simulations
Scatterings, particularly those involving resonances, and other elementary
processes do not happen instantaneously. In the context of semiclassical
nuclear reaction simulations, we consider delays associated with an interaction
for incident quantum wave-packets. As a consequence, we express delays
associated with elementary processes in terms of elements of the scattering
matrix and phase shifts for elastic scattering. We show that, to within the
second order in density, the simulation must account for delays in scattering
consistently with the mean field in order to properly model thermodynamic
properties such as pressure and free-energy density. The delays associated with
nucleon-nucleon and pion-nucleon scattering in free space are analysed with
their nontrivial energy dependence. Finally, an example of s-channel scattering
of massless partons is studied, and scattering schemes in nuclear reaction
simulations are investigated in the context of scattering delays.Comment: 45 pages, 5 uuencoded Postscript figure
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