73 research outputs found
Vasopressin modulates social recognition-related activity in the left temporoparietal junction in humans
The neuropeptide vasopressin is a key molecular mediator of social behavior in animals and humans, implicated in anxiety and autism. Social recognition, the ability to assess the familiarity of others, is essential for appropriate social interactions and enhanced by vasopressin; however, the neural mechanisms mediating this effect in humans are unknown. Using functional magnetic resonance imaging (fMRI) and an implicit social recognition matching task, we employed a double-blinded procedure in which 20 healthy male volunteers self-administered 40 UI of vasopressin or placebo intranasally, 45βmin before performing the matching task in the scanner. In a random-effects fMRI analysis, we show that vasopressin induces a regionally specific alteration in a key node of the theory of mind network, the left temporoparietal junction, identifying a neurobiological mechanism for prosocial neuropeptide effects in humans that suggests novel treatment strategies
The Vehicle, Fall 1984
Vol. 26, No. 1
Table of Contents
Thoughts on I-57Jim Caldwellpage 3
A Night Between Lonely and BlindJennifer K. Soulepage 4
What is Unnatural is Sometimes MagicAngelique Jenningspage 4
Cutting ClosenessBecky Lawsonpage 5
PhotoBrian Ormistonpage 6
The Sensuality of Corn One Week in AugustMichelle Mitchellpage 7
American MusicJim Caldwellpage 7
Water is WaitingMichael Kuopage 8
WhereJennifer K. Soulepage 8
The Fishing HoleJan Kowalskipage 9
Miller\u27s PondSue Gradypage 9
PhotoCathy Stonerpage 11
Young Man Reading To His LoverMaggie Kennedypage 11
ShellsChristopher R. Albinpage 12
In The ShadeJohn Fehrmannpage 12
FallLynanne Feilenpage 13
IndecisionDave L. Brydenpage 13
Dark Falls SoftlyAngelique Jenningspage 14
Not a Parked \u2757 Chevy in the Summer in the CountryMichelle Mitchellpage 20
BirdAnnie Heisepage 20
Clouds Created Only For Poets And Certain WomenJennifer K. Soulepage 21
SandGraham Lewispage 22
PhotoFred Zwickypage 23
Judgment CallCathy Moepage 23
I was hip that night Dan Hintzpage 24
A Sight Of WindDan Von Holtenpage 25
Tillard Isabel M. Parrottpage 26
The WidowMaggie Kennedypage 27
The SeparationMichelle Mitchellpage 27
The Garden Hose TrialMaggie Kennedypage 28
InterruptionsJennifer K. Soulepage 28
On Happening Across Jesus While Cleaning the BasementMaggie Kennedypage 29
GileonMichelle Mitchellpage 30
If My Father Were A Writer, He Would Still BuildAngelique Jenningspage 36
A Visit to Grandpa Gib\u27s HouseTammy Veachpage 37
For Having SeenAngelique Jenningspage 38
PhotoJudy Klancicpage 39
The Earth in BlueSusan J. Bielskypage 39
Things I Could Have SaidAngelique Jenningspage 40
AcrosticsAnnie Heisepage 40https://thekeep.eiu.edu/vehicle/1044/thumbnail.jp
The Vehicle, Fall 1984
Vol. 26, No. 1
Table of Contents
Thoughts on I-57Jim Caldwellpage 3
A Night Between Lonely and BlindJennifer K. Soulepage 4
What is Unnatural is Sometimes MagicAngelique Jenningspage 4
Cutting ClosenessBecky Lawsonpage 5
PhotoBrian Ormistonpage 6
The Sensuality of Corn One Week in AugustMichelle Mitchellpage 7
American MusicJim Caldwellpage 7
Water is WaitingMichael Kuopage 8
WhereJennifer K. Soulepage 8
The Fishing HoleJan Kowalskipage 9
Miller\u27s PondSue Gradypage 9
PhotoCathy Stonerpage 11
Young Man Reading To His LoverMaggie Kennedypage 11
ShellsChristopher R. Albinpage 12
In The ShadeJohn Fehrmannpage 12
FallLynanne Feilenpage 13
IndecisionDave L. Brydenpage 13
Dark Falls SoftlyAngelique Jenningspage 14
Not a Parked \u2757 Chevy in the Summer in the CountryMichelle Mitchellpage 20
BirdAnnie Heisepage 20
Clouds Created Only For Poets And Certain WomenJennifer K. Soulepage 21
SandGraham Lewispage 22
PhotoFred Zwickypage 23
Judgment CallCathy Moepage 23
I was hip that night Dan Hintzpage 24
A Sight Of WindDan Von Holtenpage 25
Tillard Isabel M. Parrottpage 26
The WidowMaggie Kennedypage 27
The SeparationMichelle Mitchellpage 27
The Garden Hose TrialMaggie Kennedypage 28
InterruptionsJennifer K. Soulepage 28
On Happening Across Jesus While Cleaning the BasementMaggie Kennedypage 29
GileonMichelle Mitchellpage 30
If My Father Were A Writer, He Would Still BuildAngelique Jenningspage 36
A Visit to Grandpa Gib\u27s HouseTammy Veachpage 37
For Having SeenAngelique Jenningspage 38
PhotoJudy Klancicpage 39
The Earth in BlueSusan J. Bielskypage 39
Things I Could Have SaidAngelique Jenningspage 40
AcrosticsAnnie Heisepage 40https://thekeep.eiu.edu/vehicle/1044/thumbnail.jp
The Oxytocin Receptor (OXTR) Contributes to Prosocial Fund Allocations in the Dictator Game and the Social Value Orientations Task
Background: Economic games observe social decision making in the laboratory that involves real money payoffs. Previously we have shown that allocation of funds in the Dictator Game (DG), a paradigm that illustrates costly altruistic behavior, is partially determined by promoter-region repeat region variants in the arginine vasopressin 1a receptor gene (AVPR1a). In the current investigation, the gene encoding the related oxytocin receptor (OXTR) was tested for association with the DG and a related paradigm, the Social Values Orientation (SVO) task. Methodology/Principal Findings: Association (101 male and 102 female students) using a robust-family based test between 15 single tagging SNPs (htSNPs) across the OXTR was demonstrated with both the DG and SVO. Three htSNPs across the gene region showed significant association with both of the two games. The most significant association was observed with rs1042778 (p = 0.001). Haplotype analysis also showed significant associations for both DG and SVO. Following permutation test adjustment, significance was observed for 2β5 locus haplotypes (p,0.05). A second sample of 98 female subjects was subsequently and independently recruited to play the dictator game and was genotyped for the three significant SNPs found in the first sample. The rs1042778 SNP was shown to be significant for the second sample as well (p = 0.004, Fisherβs exact test). Conclusions: The demonstration that genetic polymorphisms for the OXTR are associated with human prosocial decisio
Progestin Receptor-Mediated Reduction of Anxiety-Like Behavior in Male Rats
BACKGROUND: It is well known progesterone can have anxiolytic-like effects in animals in a number of different behavioral testing paradigms. Although progesterone is known to influence physiology and behavior by binding to classical intracellular progestin receptors, progesterone's anxiety reducing effects have solely been attributed to its rapid non-genomic effects at the GABA A receptor. This modulation occurs following the bioconversion of progesterone to allopregnanolone. Seemingly paradoxical results from some studies suggested that the function of progesterone to reduce anxiety-like behavior may not be entirely clear; therefore, we hypothesized that progesterone might also act upon progestin receptors to regulate anxiety. METHODOLOGY/PRINCIPAL FINDINGS: To test this, we examined the anxiolytic-like effects of progesterone in male rats using the elevated plus maze, a validated test of anxiety, and the light/dark chamber in the presence or absence of a progestin receptor antagonist, RU 486. Here we present evidence suggesting that the anxiolytic-like effects of progesterone in male rats can be mediated, in part, by progestin receptors, as these effects are blocked by prior treatment with a progestin receptor antagonist. CONCLUSION/SIGNIFICANCE: This indicates that progesterone can act upon progestin receptors to regulate anxiety-like behavior in the male rat brain
Long-Lasting Consequences of Neonatal Maternal Separation on Social Behaviors in Ovariectomized Female Mice
Maternal separation (MS) stress is known to induce long-lasting alterations in emotional and anxiety-related behaviors, but effects on social behaviors are not well defined. The present study examined MS effects on female social behaviors in the social investigation (SIT) and social preference (SPT) tests, in addition to non-social behaviors in the open-field (OFT) and light-dark transition (LDT) tests in C57BL/6J mice. All females were tested as ovariectomized to eliminate confounding effects of endogenous estrogen during behavioral testing. Daily MS (3 hr) from postnatal day 1 to 14 did not affect anxiety levels in LDT, but were elevated in OFT with modified behavioral responses to the novel environment. Furthermore, MS altered social investigative behaviors and preference patterns toward unfamiliar stimulus mice in SIT and short- and long-term SPT paradigms. In SIT, MS reduced social investigation duration and increased number of stretched approaches towards both female and male unfamiliar stimulus mice, suggesting increased social anxiety levels in MS females. Similarly, MS heightened levels of social anxiety during short-term SPT but no MS effect on social preference was found. On the other hand, MS females displayed a distinctive preference for female stimuli, unlike control females, when tested for long-term SPT over a prolonged period of 5 days. Evaluation of FosB expression in the paraventricular nucleus, medial and central amygdala following stimulus exposure demonstrated greater number of FosB immunopositive cells in all three brain regions in MS females compared to control females. These results suggest that MS females might differ in neuroendocrine responses toward unfamiliar female and male opponents, which may be associated with modifications in social behaviors found in the present study. Taken together, this study provides new evidence that early life stress modifies female social behaviors by highlighting alterations in behavioral responses to situations involving social as well as non-social novelty
Neural Circuits Underlying Rodent Sociality: A Comparative Approach
All mammals begin life in social groups, but for some species, social relationships persist and develop throughout the course of an individualβs life. Research in multiple rodent species provides evidence of relatively conserved circuitry underlying social behaviors and processes such as social recognition and memory, social reward, and social approach/avoidance. Species exhibiting different complex social behaviors and social systems (such as social monogamy or familiarity preferences) can be characterized in part by when and how they display specific social behaviors. Prairie and meadow voles are closely related species that exhibit similarly selective peer preferences but different mating systems, aiding direct comparison of the mechanisms underlying affiliative behavior. This chapter draws on research in voles as well as other rodents to explore the mechanisms involved in individual social behavior processes, as well as specific complex social patterns. Contrasts between vole species exemplify how the laboratory study of diverse species improves our understanding of the mechanisms underlying social behavior. We identify several additional rodent species whose interesting social structures and available ecological and behavioral field data make them good candidates for study. New techniques and integration across laboratory and field settings will provide exciting opportunities for future mechanistic work in non-model species
Genetic Overexpression of NR2B Subunit Enhances Social Recognition Memory for Different Strains and Species
The ability to learn and remember conspecifics is essential for the establishment and maintenance of social groups. Many animals, including humans, primates and rodents, depend on stable social relationships for survival. Social learning and social recognition have become emerging areas of interest for neuroscientists but are still not well understood. It has been established that several hormones play a role in the modulation of social recognition including estrogen, oxytocin and arginine vasopression. Relatively few studies have investigated how social recognition might be improved or enhanced. In this study, we investigate the role of the NMDA receptor in social recognition memory, specifically the consequences of altering the ratio of the NR2BβΆNR2A subunits in the forebrain regions in social behavior. We produced transgenic mice in which the NR2B subunit of the NMDA receptor was overexpressed postnatally in the excitatory neurons of the forebrain areas including the cortex, amygdala and hippocampus. We investigated the ability of both our transgenic animals and their wild-type littermate to learn and remember juvenile conspecifics using both 1-hr and 24-hr memory tests. Our experiments show that the wild-type animals and NR2B transgenic mice preformed similarly in the 1-hr test. However, transgenic mice showed better performances in 24-hr tests of recognizing animals of a different strain or animals of a different species. We conclude that NR2B overexpression in the forebrain enhances social recognition memory for different strains and animal species
Multiple Organ System Defects and Transcriptional Dysregulation in the Nipbl+/β Mouse, a Model of Cornelia de Lange Syndrome
Cornelia de Lange Syndrome (CdLS) is a multi-organ system birth defects disorder linked, in at least half of cases, to heterozygous mutations in the NIPBL gene. In animals and fungi, orthologs of NIPBL regulate cohesin, a complex of proteins that is essential for chromosome cohesion and is also implicated in DNA repair and transcriptional regulation. Mice heterozygous for a gene-trap mutation in Nipbl were produced and exhibited defects characteristic of CdLS, including small size, craniofacial anomalies, microbrachycephaly, heart defects, hearing abnormalities, delayed bone maturation, reduced body fat, behavioral disturbances, and high mortality (75β80%) during the first weeks of life. These phenotypes arose despite a decrease in Nipbl transcript levels of only βΌ30%, implying extreme sensitivity of development to small changes in Nipbl activity. Gene expression profiling demonstrated that Nipbl deficiency leads to modest but significant transcriptional dysregulation of many genes. Expression changes at the protocadherin beta (Pcdhb) locus, as well as at other loci, support the view that NIPBL influences long-range chromosomal regulatory interactions. In addition, evidence is presented that reduced expression of genes involved in adipogenic differentiation may underlie the low amounts of body fat observed both in Nipbl+/β mice and in individuals with CdLS
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