327 research outputs found
Microwave Penetration Depth and Quasiparticle Conductivity in PrFeAsO_1-y Single Crystals : Evidence for a Full-Gap Superconductor
In-plane microwave penetration depth and quaiparticle
conductivity at 28 GHz are measured in underdoped single crystals of the
Fe-based superconductor PrFeAsO ( K) by using a
sensitive superconducting cavity resonator. shows flat
dependence at low temperatures, which is incompatible with the presence of
nodes in the superconducting gap . The temperature dependence
of the superfluid density demonstrates that the gap is non-zero
() all over the Fermi surface. The microwave
conductivity below exhibits an enhancement larger than the coherence
peak, reminiscent of high- cuprate superconductors.Comment: 4 pages, 3 figures. Version accepted for publication in Phys. Rev.
Lett. For related results of hole-doped 122 system, see arXiv:0810.350
Microwave Surface-Impedance Measurements of the Magnetic Penetration Depth in Single Crystal Ba1-xKxFe2As2 Superconductors: Evidence for a Disorder-Dependent Superfluid Density
We report high-sensitivity microwave measurements of the in-plane penetration
depth and quasiparticle scattering rate in several
single crystals of hole-doped Fe-based superconductor
BaKFeAs (). While power-law temperature
dependence of with the power is found in crystals with
large , we observe exponential temperature dependence of superfluid
density consistent with the existence of fully opened two gaps in the cleanest
crystal we studied. The difference may be a consequence of different level of
disorder inherent in the crystals. We also find a linear relation between the
low-temperature scattering rate and the density of quasiparticles, which shows
a clear contrast to the case of d-wave cuprate superconductors with nodes in
the gap. These results demonstrate intrinsically nodeless order parameters in
the Fe-arsenides.Comment: 4 pages, 4 figures, 1 table. Accepted for publication in Phys. Rev.
Lett. Changed title as suggested by the PRL editor
Structural properties and superconductivity of SrFe2As2-xPx and CaFe2As2-yPy
The SrFe2As2-xPx and CaFe2As2-yPy materials were prepared by a solid state
reaction method. X-ray diffraction measurements indicate the single-phase
samples can be successfully obtained for SrFe2As2-xPx and CaFe2As2-yPy samples.
Clear contraction of the lattice parameters are clearly determined due to the
relatively smaller P ions substation for As. The SDW instability associated
with tetragonal to orthorhombic phase transition is suppressed visibly in both
systems following with the increase of P contents. The highest superconducting
transitions are respectively observed at about 27 K in SrFe2As1.3P0.7 and at
about 13 K in CaFe2As1.7P0.3.Comment: 11 pages, 5 figures, 2 table
A genistein derivative, ITB-301, induces microtubule depolymerization and mitotic arrest in multidrug-resistant ovarian cancer
PURPOSE: To investigate the mechanistic basis of the anti-tumor effect of the compound ITB-301. METHODS: Chemical modifications of genistein have been introduced to improve its solubility and efficacy. The anti-tumor effects were tested in ovarian cancer cells using proliferation assays, cell cycle analysis, immunofluorescence, and microscopy. RESULTS: In this work, we show that a unique glycoside of genistein, ITB-301, inhibits the proliferation of SKOv3 ovarian cancer cells. We found that the 50% growth inhibitory concentration of ITB-301 in SKOv3 cells was 0.5Ā Ī¼M. Similar results were obtained in breast cancer, ovarian cancer, and acute myelogenous leukemia cell lines. ITB-301 induced significant time- and dose-dependent microtubule depolymerization. This depolymerization resulted in mitotic arrest and inhibited proliferation in all ovarian cancer cell lines examined including SKOv3, ES2, HeyA8, and HeyA8-MDR cells. The cytotoxic effect of ITB-301 was dependent on its induction of mitotic arrest as siRNA-mediated depletion of BUBR1 significantly reduced the cytotoxic effects of ITB-301, even at a concentration of 10Ā Ī¼M. Importantly, efflux-mediated drug resistance did not alter the cytotoxic effect of ITB-301 in two independent cancer cell models of drug resistance. CONCLUSION: These results identify ITB-301 as a novel anti-tubulin agent that could be used in cancers that are multidrug resistant. We propose a structural model for the binding of ITB-301 to Ī±- and Ī²-tubulin dimers on the basis of molecular docking simulations. This model provides a rationale for future work aimed at designing of more potent analogs
Multi-Layered Films Containing a Biomimetic Stimuli-Responsive Recombinant Protein
Electrostatic self-assembly was used to fabricate new smart multi-layer coatings, using a recombinant elastin-like polymer (ELP) and chitosan as the counterion macromolecule. The ELP was bioproduced, purified and its purity and expected molecular weight were assessed. Aggregate size measurements, obtained by light scattering of dissolved ELP, were performed as a function of temperature and pH to assess the smart properties of the polymer. The build-up of multi-layered films containing ELP and chitosan, using a layer-by-layer methodology, was followed by quartz-crystal microbalance with dissipation monitoring. Atomic force microscopy analysis permitted to demonstrate that the topography of the multi-layered films could respond to temperature. This work opens new possibilities for the use of ELPs in the fabrication of biodegradable smart coatings and films, offering new platforms in biotechnology and in the biomedical area
Crucial Differences in the Hydrolytic Degradation between Industrial Polylactide and Laboratory-Scale Poly(L-lactide)
Reconstruction of abdominal wall defects using small intestinal submucosa coated with gelatin hydrogel incorporating basic fibroblast growth factor
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