Biermann Mechanism in Primordial Supernova Remnant and Seed Magnetic Fields

We study generation of magnetic fields by the Biermann mechanism in the pair-instability supernovae explosions of first stars. The Biermann mechanism produces magnetic fields in the shocked region between the bubble and interstellar medium (ISM), even if magnetic fields are absent initially. We perform a series of two-dimensional magnetohydrodynamic simulations with the Biermann term and estimate the amplitude and total energy of the produced magnetic fields. We find that magnetic fields with amplitude $10^{-14}-10^{-17}$ G are generated inside the bubble, though the amount of magnetic fields generated depend on specific values of initial conditions. This corresponds to magnetic fields of $10^{28}-10^{31}$ erg per each supernova remnant, which is strong enough to be the seed magnetic field for galactic and/or interstellar dynamo.Comment: 12 pages, 3 figure

Effect of Primordial Magnetic Field on Seeds for Large Scale Structure

Magnetic field plays a very important role in many astronomical phenomena at various scales of the universe. It is no exception in the early universe. Since the energy density, pressure, and tension of the primordial magnetic field affect gravitational collapses of plasma, the formation of seeds for large scale structures should be influenced by them. Here we numerically investigate the effects of stochastic primordial magnetic field on the seeds of large scale structures in the universe in detail. We found that the amplitude ratio between the density spectra with and without PMF ($|P(k)/P_0(k)|$ at $k>0.2$ Mpc$^{-1}$) lies between 75% and 130% at present for the range of PMF strengths 0.5 nG $< B_\lambda < 1.0$ nG, depending on the spectral index of PMF and the correlation between the matter density and the PMF distributions.Comment: 20 pages, 5 figures, submitted to PRD 23 Jan 2006, Revised 02 Oct 2006, accepted for publication in PR

MFGE8 does not influence chorio-retinal homeostasis or choroidal neovascularization in vivo

Purpose: Milk fat globule-epidermal growth factor-factor VIII (MFGE8) is necessary for diurnal outer segment phagocytosis and promotes VEGF-dependent neovascularization. The prevalence of two single nucleotide polymorphisms (SNP) in MFGE8 was studied in two exsudative or “wet” Age-related Macular Degeneration (AMD) groups and two corresponding control groups. We studied the effect of MFGE8 deficiency on retinal homeostasis with age and on choroidal neovascularization (CNV) in mice. Methods: The distribution of the SNP (rs4945 and rs1878326) of MFGE8 was analyzed in two groups of patients with “wet” AMD and their age-matched controls from Germany and France. MFGE8-expressing cells were identified in Mfge8+/− mice expressing ß-galactosidase. Aged Mfge8+/− and Mfge8−/− mice were studied by funduscopy, histology, electron microscopy, scanning electron microscopy of vascular corrosion casts of the choroid, and after laser-induced CNV. Results: rs1878326 was associated with AMD in the French and German group. The Mfge8 promoter is highly active in photoreceptors but not in retinal pigment epithelium cells. Mfge8−/− mice did not differ from controls in terms of fundus appearance, photoreceptor cell layers, choroidal architecture or laser-induced CNV. In contrast, the Bruch's membrane (BM) was slightly but significantly thicker in Mfge8−/− mice as compared to controls. Conclusions: Despite a reproducible minor increase of rs1878326 in AMD patients and a very modest increase in BM in Mfge8−/− mice, our data suggests that MFGE8 dysfunction does not play a critical role in the pathogenesis of AMD

The interrelation between the generation of large-scale electric fields and that of large-scale magnetic fields during inflation

The interrelation between the generation of large-scale electric fields and that of large-scale magnetic fields due to the breaking of the conformal invariance of the electromagnetic field in inflationary cosmology is studied. It is shown that if large-scale magnetic fields with a sufficiently large amplitude are generated during inflation, the generation of large-scale electric fields is suppressed, and vice versa. Furthermore, a physical interpretation of the result and its cosmological significance are considered.Comment: 12 pages, no figure, title changed, typos correcte

Primordial magnetic fields from second-order cosmological perturbations: Tight coupling approximation

We explore the possibility of generating large-scale magnetic fields from second-order cosmological perturbations during the pre-recombination era. The key process for this is Thomson scattering between the photons and the charged particles within the cosmic plasma. To tame the multi-component interacting fluid system, we employ the tight coupling approximation. It is shown that the source term for the magnetic field is given by the vorticity, which signals the intrinsically second-order quantities, and the product of the first order perturbations. The vorticity itself is sourced by the product of the first-order quantities in the vorticity evolution equation. The magnetic fields generated by this process are estimated to be $\sim 10^{-29}$Gauss on the horizon scale at the recombination epoch. Although our rough estimate suggests that the current generation mechanism can work even on smaller scales, more careful investigation is needed to make clear whether it indeed works in a wide range of spatial scales.Comment: 10pages, minor corrections, accepted for publication in Class. Quant. Gra

MFG-E8 Regulates the Immunogenic Potential of Dendritic Cells Primed with Necrotic Cell-Mediated Inflammatory Signals

Dendritic cells (DC) manipulate tissue homeostasis by recognizing dying cells and controlling immune functions. However, the precise mechanisms by which DC recognize different types of dying cells and devise distinct immunologic consequences remain largely obscure. Herein, we demonstrate that Milk-fat globule-EGF VIII (MFG-E8) is a critical mediator controlling DC immunogenicity in inflammatory microenvironments. MFG-E8 restrains DC-mediated uptake and recognition of necrotic cells. The MFG-E8-mediated suppression of necrotic cell uptake by DC resulted in the decreased proinflammatory cytokines production and activated signal components such as STAT3 and A20, which are critical to maintain tolerogenic properties of DC. Furthermore, the DC-derived MFG-E8 negatively regulates the cross-priming and effector functions of antigen-specific T cells upon recognition of necrotic cells. MFG-E8 deficiency enhances an ability of necrotic cell-primed DC to stimulate antitumor immune responses against established tumors. Our findings define what we believe to a novel mechanism whereby MFG-E8 regulates the immunogenicity of DC by modulating the modes of recognition of dying cells. Manipulating MFG-E8 levels in DC may serve as a useful strategy for controlling inflammatory microenvironments caused by various pathological conditions including cancer and autoimmunity

Identification of Novel Genes Selectively Expressed in the Follicle-Associated Epithelium from the Meta-Analysis of Transcriptomics Data from Multiple Mouse Cell and Tissue Populations

The follicle-associated epithelium (FAE) overlying the Peyer’s patches and the microfold cells (M cells) within it are important sites of antigen transcytosis across the intestinal epithelium. Using a meta-analysis approach, we identified a transcriptional signature that distinguished the FAE from a large collection of mouse cells and tissues. A co-expressed cluster of 21 FAE-specific genes was identified, and the analysis of the transcription factor binding site motifs in their promoter regions indicated that these genes shared an underlying transcriptional programme. This cluster contained known FAE- (Anxa10, Ccl20, Psg18 and Ubd) and M-cell-specific (Gp2) genes, suggesting that the others were novel FAE-specific genes. Some of these novel candidate genes were expressed highly by the FAE and M cells (Calcb, Ces3b, Clca2 and Gjb2), and others only by the FAE (Ascl2, Cftr, Fgf15, Gpr133, Kcna1, Kcnj15,Mycl1, Pgap1 and Rps6kl). We also identified a subset of novel FAE-related genes that were induced in the intestinal epithelium after receptor activatorof nuclear factor (NF)-kB ligand stimulation. These includedMfge8whichwas specific to FAE enter-ocytes. This studyprovides new insight into the FAE transcriptome. Furthercharacterizationof the candidate genes identified here will aid the identification of novel regulators of cell function in the FAE