Shape Coexistence and the Effective Nucleon-Nucleon Interaction

The phenomenon of shape coexistence is discussed within the self-consistent Hartree-Fock method and the nuclear shell model. The occurrence of the coexisting configurations with different intrinsic shapes is traced back to the properties of the effective Hamiltonian.Comment: 40 pages (16 text, 24 figures). The file may also be retrieved at http://csep2.phy.ornl.gov/theory_group/people/dean/shape_coex/shapes.htm

Evidence for bystander signalling between human trophoblast cells and human embryonic stem cells

Maternal exposure during pregnancy to toxins can occasionally lead to miscarriage and malformation. It is currently thought that toxins pass through the placental barrier, albeit bilayered in the first trimester, and damage the fetus directly, albeit at low concentration. Here we examined the responses of human embryonic stem (hES) cells in tissue culture to two metals at low concentration. We compared direct exposures with indirect exposures across a bi-layered model of the placenta cell barrier. Direct exposure caused increased DNA damage without apoptosis or a loss of cell number but with some evidence of altered differentiation. Indirect exposure caused increased DNA damage and apoptosis but without loss of pluripotency. This was not caused by metal ions passing through the barrier. Instead the hES cells responded to signalling molecules (including TNF-α) secreted by the barrier cells. This mechanism was dependent on connexin 43 mediated intercellular ‘bystander signalling’ both within and between the trophoblast barrier and the hES colonies. These results highlight key differences between direct and indirect exposure of hES cells across a trophoblast barrier to metal toxins. It offers a theoretical possibility that an indirectly mediated toxicity of hES cells might have biological relevance to fetal development

FGF4 Independent Derivation of Trophoblast Stem Cells from the Common Vole

The derivation of stable multipotent trophoblast stem (TS) cell lines from preimplantation, and early postimplantation mouse embryos has been reported previously. FGF4, and its receptor FGFR2, have been identified as embryonic signaling factors responsible for the maintenance of the undifferentiated state of multipotent TS cells. Here we report the derivation of stable TS-like cell lines from the vole M. rossiaemeridionalis, in the absence of FGF4 and heparin. Vole TS-like cells are similar to murine TS cells with respect to their morphology, transcription factor gene expression and differentiation in vitro into derivatives of the trophectoderm lineage, and with respect to their ability to invade and erode host tissues, forming haemorrhagic tumours after subcutaneous injection into nude mice. Moreover, vole TS-like cells carry an inactive paternal X chromosome, indicating that they have undergone imprinted X inactivation, which is characteristic of the trophoblast lineage. Our results indicate that an alternative signaling pathway may be responsible for the establishment and stable proliferation of vole TS-like cells

Концептуальные модели и возможные пути поиска залежей углеводородов в доюрском комплексе Томской области: сборник научных трудов открытой научной конференции, Томск, 6, 21 июня 2018 г.

В сборнике представлены материалы, посвященные вопросам изучения отложений доюрского комплекса передовых ученых Томской и Новосибирской областей. Сборник содержит краткий очерк истории изучения доюрского комплекса Западной Сибири, а также практические рекомендации по поиску залежей нефти и газа в доюрском комплексе Томской области. Сборник подготовлен в рамках распоряжения Правительства РФ от 14 января 2015 года о создании инновационного территориального центра «ИНО Томск» по освоению ТРИЗ с участием ООО "Газпромнефть-Восток" и проекта "Палеозой" по освоению нефтегазоносных доюрских образований Томской области с реализацией на базе Томского политехнического университета. Предназначен для студентов, аспирантов, молодых ученых, начавших свой научный путь в изучении сложного вопроса поиска залежей в доюрском комплексе, а также для геологов и инженеров, непосредственно связанных с изучением данного вопроса на производстве