365 research outputs found
Statistics in the Landscape of Intersecting Brane Models
An approach towards a statistical survey of four dimensional supersymmetric
vacua in the string theory landscape is described and illustrated with three
examples of ensembles of intersecting D-brane models. The question whether it
is conceivable to make predictions based on statistical distributions is
discussed. Especially interesting in this context are possible correlations
between low energy observables. As an example we look at correlations between
properties of the gauge sector of intersecting D-brane models and Gepner model
constructions.Comment: Submitted for the SUSY07 proceedings, 4 pages, 2 figure
Diversity in the Tail of the Intersecting Brane Landscape
Techniques are developed for exploring the complete space of intersecting
brane models on an orientifold. The classification of all solutions for the
widely-studied T^6/Z_2 x Z_2 orientifold is made possible by computing all
combinations of branes with negative tadpole contributions. This provides the
necessary information to systematically and efficiently identify all models in
this class with specific characteristics. In particular, all ways in which a
desired group G can be realized by a system of intersecting branes can be
enumerated in polynomial time. We identify all distinct brane realizations of
the gauge groups SU(3) x SU(2) and SU(3) x SU(2) x U(1) which can be embedded
in any model which is compatible with the tadpole and SUSY constraints. We
compute the distribution of the number of generations of "quarks" and find that
3 is neither suppressed nor particularly enhanced compared to other odd
generation numbers. The overall distribution of models is found to have a long
tail. Despite disproportionate suppression of models in the tail by K-theory
constraints, the tail in the distribution contains much of the diversity of
low-energy physics structure.Comment: 48 pages, 8 figure
Yukawa couplings and masses of non-chiral states for the Standard Model on D6-branes on T6/Z6'
The perturbative leading order open string three-point couplings for the
Standard Model with hidden USp(6) on fractional D6-branes on T6/Z6' from
arXiv:0806.3039 [hep-th], arXiv:0910.0843 [hep-th] are computed. Physical
Yukawa couplings consisting of holomorphic Wilsonian superpotential terms times
a non-holomorphic prefactor involving the corresponding classical open string
Kaehler metrics are given, and mass terms for all non-chiral matter states are
derived. The lepton Yukawa interactions are at leading order flavour diagonal,
while the quark sector displays a more intricate pattern of mixings. While N=2
supersymmetric sectors acquire masses via only two D6-brane displacements -
which also provide the hierarchies between up- and down-type Yukawas within one
quark or lepton generation -, the remaining vector-like states receive masses
via perturbative three-point couplings to some Standard Model singlet fields
with vevs along flat directions. Couplings to the hidden sector and messengers
for supersymmetry breaking are briefly discussed.Comment: 52 pages (including 8p. appendix); 5 figures; 14 tables; v2:
discussion in section 4.1.3 extended, footnote 5 added, typos corrected,
accepted by JHE
Selection Of A Novel Aptamer Against Vitronectin Using Capillary Electrophoresis And Next Generation Sequencing
Breast cancer (BC) results in â40,000 deaths each year in the United States and even among survivors treatment of the disease may have devastating consequences, including increased risk for heart disease and cognitive impairment resulting from the toxic effects of chemotherapy. Aptamer-mediated drug delivery can contribute to improved treatment outcomes through the selective delivery of chemotherapy to BC cells, provided suitable cancer-specific antigens can be identified. We report here the use of capillary electrophoresis in conjunction with next generation sequencing to develop the first vitronectin (VN) binding aptamer (VBA-01; Kd 405 nmol/l, the first aptamer to vitronectin (VN; Kd = 405 nmol/l), a protein that plays an important role in wound healing and that is present at elevated levels in BC tissue and in the blood of BC patients relative to the corresponding nonmalignant tissues. We used VBA-01 to develop DVBA-01, a dimeric aptamer complex, and conjugated doxorubicin (Dox) to DVBA-01 (7:1 ratio) using pH-sensitive, covalent linkages. Dox conjugation enhanced the thermal stability of the complex (60.2 versus 46.5°C) and did not decrease affinity for the VN target. The resulting DVBA-01-Dox complex displayed increased cytotoxicity to MDA-MB-231 BC cells that were cultured on plasticware coated with VN (1.8âĂâ10â»â¶mol/l) relative to uncoated plates (2.4âĂâ10â»â¶ mol/l), or plates coated with the related protein fibronectin (2.1âĂâ10â»â¶ mol/l). The VBA-01 aptamer was evaluated for binding to human BC tissue using immunohistochemistry and displayed tissue specific binding and apparent association with BC cells. In contrast, a monoclonal antibody that preferentially binds to multimeric VN primarily stained extracellular matrix and vessel walls of BC tissue. Our results indicate a strong potential for using VN-targeting aptamers to improve drug delivery to treat BC
Free Fermionic Heterotic Model Building and Root Systems
We consider an alternative derivation of the GSO Projection in the free
fermionic construction of the weakly coupled heterotic string in terms of root
systems, as well as the interpretation of the GSO Projection in this picture.
We then present an algorithm to systematically and efficiently generate input
sets (i.e. basis vectors) in order to study Landscape statistics with minimal
computational cost. For example, the improvement at order 6 is approximately
10^{-13} over a traditional brute force approach, and improvement increases
with order. We then consider an example of statistics on a relatively simple
class of models.Comment: Standard Latex, 12 page
Intersecting D-Branes on Shift Z2 x Z2 Orientifolds
We investigate Z2 x Z2 orientifolds with group actions involving shifts. A
complete classification of possible geometries is presented where also previous
work by other authors is included in a unified framework from an intersecting
D-brane perspective. In particular, we show that the additional shifts not only
determine the topology of the orbifold but also independently the presence of
orientifold planes. In the second part, we work out in detail a basis of
homological three cycles on shift Z2 x Z2 orientifolds and construct all
possible fractional D-branes including rigid ones. A Pati-Salam type model with
no open-string moduli in the visible sector is presented.Comment: 36 pages, 4 figures, refs. adde
Merging Heterotic Orbifolds and K3 Compactifications with Line Bundles
We clarify the relation between six-dimensional Abelian orbifold
compactifications of the heterotic string and smooth heterotic K3
compactifications with line bundles for both SO(32) and E_8 x E_8 gauge groups.
The T^4/Z_N cases for N=2,3,4 are treated exhaustively, and for N=6 some
examples are given. While all T^4/Z_2 and nearly all T^4/Z_3 models have a
simple smooth match involving one line bundle only, this is only true for some
T^4/Z_4 and T^4/Z_6 cases. We comment on possible matchings with more than one
line bundle for the remaining cases. The matching is provided by comparisons of
the massless spectra and their anomalies as well as a field theoretic analysis
of the blow-ups.Comment: 49 pages, 1 figure; v2: references adde
DBI Inflation using a One-Parameter Family of Throat Geometries
We demonstrate the possibility of examining cosmological signatures in the
DBI inflation setup using the BGMPZ solution, a one-parameter family of
geometries for the warped throat which interpolate between the Maldacena-Nunez
and Klebanov-Strassler solutions. The warp factor is determined numerically and
subsequently used to calculate cosmological observables including the scalar
and tensor spectral indices, for a sample point in the parameter space. As one
moves away from the KS solution for the throat the warp factor is qualitatively
different, which leads to a significant change for the observables, but also
generically increases the non-Gaussianity of the models. We argue that the
different models can potentially be differentiated by current and future
experiments.Comment: 17 pages, 10 figures; v2: section 4 expanded, references added; v3:
typos fixe
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