Konsep Pengembangan Kawasan Desa Wisata di Desa Bandungan Kecamatan Pakong Kabupaten Pamekasan

Kawasan Desa Bandungan adalah salah satu potensi desa wisata yang dimiliki oleh Kabupaten Pamekasan yang terletak di Kecamatan Pakong, Desa Bandungan ini memiliki bentangan lahan perhatian yang luas yang bisa di manfaatkan sebagai objek wisata alam dan berbagi komoditi hasil tani. Selain itu, Desa Bandungan juga memiliki keaslian, keunikan, sifat khas dari segi bangunan, sosial dan budaya. Potensi ini masih belum di manfaatkan dan dikembangkan oleh masyarakat setempat sampai saat ini. Dalam penelitian ini dilakukan penentuan faktor-faktor yang dapat mendukung pengembangan kawasan desa wisata dan Perumusan konsep pengembangan kawasan desa wisata di Desa Bandungan. Tujuan penelitian ini adalah untuk menentukan konsep pengembangan kawasan desa wisata di Desa Bandungan Kecamatan Pakong, Kabupaten Pamekasan. Penelitian ini menggunakan pendekatan rasionalistik. Teknik analisa yang akan digunakan untuk mencapai tujuan dan sasaran antara lain pada sasaran pertama dengan menggunakan statistik deskriptif. Pada sasaran kedua menggunakan analisa skoring, dilanjutkan analisa delphi bertujuan untuk menentukan konsensus grup untuk faktor pendukung, pada sasaran keempat menggunakan analisis triangulasi untuk merumuskan konsep pengembangan. Penelitian ini menghasilkan konsep pengembangan secara spasial dan non spasial. Adapun konsep spasialnya dengan menyediakan rute perjalanan wisata, menyediakan sarana transportasi khusus menuju kawasan desa wisata dan menyediakan fasilitasw pendukung kegiatan wisata. Sedangkan konsep non spasialnya dengan menjadikan adat istiadat sebagai peraturan kegiatan wisata, mengembangkan kawasan desa wisata berbasis agrowisata, menyediakan fasilitas penginapan berkonsep tanean lanjheng, menyediakan toko souvenir, menyediakan fasilitas rumah makan, memberikan pelatihan kepada masyarakat, menyediakan tempat rekreasi, membuat web tentang kawasan desa wisata, melibatkan masyarakat dalam proses pengembangan dan menerapkan peraturan zonasi

Malignant melanoma and oral contraceptive use among women in California.

Women who had used oral contraceptives, particularly long-term users, were found to have higher rates of malignant melanoma and of a past history of skin cancer than those who had never used oral contraceptives. This excess was confined to lesions of the lower limb. The association between oral contraceptive use and melanoma was noted in 3 separate sets of data, although it was statistically significant only in one. The possibility that this relationship is indirect because, for example, oral contraceptive users are more likely than never-users to be exposed to sunlight and thus to develop malignant melanoma, cannot be excluded

Comparative in vitro evaluation of contact activity of fluralaner, spinosad, phoxim, propoxur, permethrin and deltamethrin against the northern fowl mite, Ornithonyssus sylviarum.

BackgroundNorthern fowl mites (Ornithonyssus sylviarum) are obligate hematophagous ectoparasites of both feral birds and poultry, particularly chicken layers and breeders. They complete their entire life-cycle on infested birds while feeding on blood. Infestations of O. sylviarum are difficult to control and resistance to some chemical classes of acaricides is a growing concern. The contact susceptibility of O. sylviarum to a new active ingredient, fluralaner, was evaluated, as well as other compounds representative of the main chemical classes commonly used to control poultry mite infestations in Europe and the USA.MethodsSix acaricides (fluralaner, spinosad, phoxim, propoxur, permethrin, deltamethrin) were dissolved and serially diluted in butanol:olive oil (1:1) to obtain test solutions used for impregnation of filter paper packets. A carrier-only control was included. Thirty adult northern fowl mites, freshly collected from untreated host chickens, were inserted into each packet for continuous compound exposure. Mite mortality was assessed after incubation of the test packets for 48 h at 75% relative humidity and a temperature of 22 °C.ResultsAdult mite LC50 /LC99 values were 2.95/8.09 ppm for fluralaner, 1587/3123 ppm for spinosad, 420/750 ppm for phoxim and 86/181 ppm for propoxur. Permethrin and deltamethrin LC values could not be calculated due to lack of mortality observed even at 1000 ppm.ConclusionsNorthern fowl mites were highly sensitive to fluralaner after contact exposure. They were moderately sensitive to phoxim and propoxur, and less sensitive to spinosad. Furthermore, the tested mite population appeared to be resistant to the pyrethroids, permethrin and deltamethrin, despite not being exposed to acaricides for at least 10 years

Social fragmentation, deprivation and urbanicity: relation to first-admission rates for psychoses

<i>Declaration</i> <i>of</i> <i>interest</i>: None. <i>Background</i>: Social disorganisation, fragmentation and isolation have long been posited as influencing the rate of psychoses at area level. Measuring such societal constructsis difficult. A census-based index measuring social fragmentation has been proposed. <i>Aims</i>: To investigate the association between first-admission rates for psychosis and area-based measures of social fragmentation, deprivation and urban/rural index. <i>Method</i>: We used indirect standardisation methods and logistic regression models to examine associations of social fragmentation, deprivation and urban/rural categories with first admissions for psychoses in Scotland for the 5-year period 1989–1993. <i>Results</i>: Areas characterised by high social fragmentation had higher first-ever admission rates for psychosis independent of deprivation and urban/rural status. There was a dose–response relationship between social fragmentation category and first-ever admission rates for psychosis. There was no statistically significant interaction between social fragmentation, deprivation and urban/rural index. <i>Conclusions</i>: First-admission rates are strongly associated with measures of social fragmentation, independent of material deprivation and urban/rural category

The Dilemma of Opioid-Induced Hyperalgesia and Tolerance in Chronic Opioid Therapy

N

Ureteral stent placement increases the risk for developing BK viremia after kidney transplantation.

The placement of ureteral stent (UrSt) at kidney transplantation reduces major urological complications but increases the risk for developing nephropathy from the BK virus. It is unclear whether UrSt placement increases nephropathy risk by increasing risk of precursor viral replication or by other mechanisms. We retrospectively investigated whether UrSt placement increased the risk for developing BK Viremia (BKVM) in adult and pediatric kidney transplants performed at the University of Florida between July 1, 2007, and December 31, 2010. In this period all recipients underwent prospective BKV PCR monitoring and were maintained on similar immunosuppression. Stent placement or not was based on surgeon preference. In 621 transplants, UrSt were placed in 295 (47.5%). BKVM was seen in 22% versus 16% without UrSt (P=0.05). In multivariate analyses, adjusting for multiple transplant covariates, only UrSt placement remained significantly associated with BKVM (P=0.04). UrSt placement significantly increased the risk for BKVM. Routine UrSt placement needs to be revaluated, since benefits may be negated by the need for more BK PCR testing and potential for graft survival-affecting nephritis

Effect of Styrene Butadiene Rubber Latex on Mechanical Properties of Eco Concrete: Limestone Powder Concrete

To make concrete a truly green material, viable cement substitutes are available. This experimental investigation is performed to study the effect of using limestone powder (LSP) and styrene butadiene rubber (SBR) latex in the concrete mix. In this work, a concrete with 1:1.8:3 cementitious material:sand:gravel and water/cement ratio w/c of 0.5 is produced. First, LSP is used with 0, 5, 10, 15, and 20% replacements by weight of cements. The fineness of the LSP is measured using sieve No. 200 and showed about 30% pass. Second, and to improve the matrix of concrete due to the dilution effect, four ratios of SBR latex (0, 5, 10, and 15%) are added by weight of cements to the mix for each LSP ratio. Compressive strength at ages of 3, 7, 14, 28, and 90 days is tested for the concrete specimens mixed with LSP only to examine its effect on concrete strength’s development with time, whereas strengths are recorded at the age of 28 days for the other concretes. Three prisms were cast for each ratio and tested at 28 days. The results show general improvements in terms of compressive and flexural strengths

Renormalized energy concentration in random matrices

We define a "renormalized energy" as an explicit functional on arbitrary point configurations of constant average density in the plane and on the real line. The definition is inspired by ideas of [SS1,SS3]. Roughly speaking, it is obtained by subtracting two leading terms from the Coulomb potential on a growing number of charges. The functional is expected to be a good measure of disorder of a configuration of points. We give certain formulas for its expectation for general stationary random point processes. For the random matrix $\beta$-sine processes on the real line (beta=1,2,4), and Ginibre point process and zeros of Gaussian analytic functions process in the plane, we compute the expectation explicitly. Moreover, we prove that for these processes the variance of the renormalized energy vanishes, which shows concentration near the expected value. We also prove that the beta=2 sine process minimizes the renormalized energy in the class of determinantal point processes with translation invariant correlation kernels.Comment: last version, to appear in Communications in Mathematical Physic