14 research outputs found
Where Does the Alignment Score Distribution Shape Come from?
Alignment algorithms are powerful tools for searching for homologous proteins in databases, providing a score for each sequence present in the database. It has been well known for 20 years that the shape of the score distribution looks like an extreme value distribution. The extremely large number of times biologists face this class of distributions raises the question of the evolutionary origin of this probability law
Variable selection for large p small n regression models with incomplete data: Mapping QTL with epistases
<p>Abstract</p> <p>Background</p> <p>Identifying quantitative trait loci (QTL) for both additive and epistatic effects raises the statistical issue of selecting variables from a large number of candidates using a small number of observations. Missing trait and/or marker values prevent one from directly applying the classical model selection criteria such as Akaike's information criterion (AIC) and Bayesian information criterion (BIC).</p> <p>Results</p> <p>We propose a two-step Bayesian variable selection method which deals with the sparse parameter space and the small sample size issues. The regression coefficient priors are flexible enough to incorporate the characteristic of "large <it>p </it>small <it>n</it>" data. Specifically, sparseness and possible asymmetry of the significant coefficients are dealt with by developing a Gibbs sampling algorithm to stochastically search through low-dimensional subspaces for significant variables. The superior performance of the approach is demonstrated via simulation study. We also applied it to real QTL mapping datasets.</p> <p>Conclusion</p> <p>The two-step procedure coupled with Bayesian classification offers flexibility in modeling "large p small n" data, especially for the sparse and asymmetric parameter space. This approach can be extended to other settings characterized by high dimension and low sample size.</p
Utilization of brewers dried grains (BDG) in growing-finishing pigs
International audienc
Adhesion, resistivity and structural, optical properties of molybdenum on steel sheet coated with barrier layer done by sol-gel for CIGS solar cells
Dielectric and diffusion barrier multilayer for Cu(In,Ga)Se solar cells integration on stainless steel sheet
Improved Model Selection Method for a Regression Function with Dependent Noise
Model selection, Nonparametric estimation, Spherically symmetric distribution, Spherically symmetric regression model,