Organs from animals for man

In the following review some of the problems of xenotransplantation shall be discussed, based on the few experimental data available so far and on reports in the literature describing investigations which may be of importance for xenotransplantation. The impact of gravity on the upright posture of man versus almost all other mammals, the dysfunction between enzymes and hormones in different species and the lack of interactions between interleukins, cytokines and vasoactive substances will be taken into consideration. The question must be asked whether different levels of carrier molecules or serum proteins play a role in the physiological network. Even though the development of transgenic animals or other imaginative manipulations may lead to the acceptance of any type of xenografted organ, it has to be established for how long the products of the xenografts are able to act in the multifactorial orchestra. We are far from understanding xenogeneic molecular mechanisms involved in toxicity, necrosis and apoptosis or even reperfusion injury and ischemia in addition to the immediate mechanisms of the hyperacute xenogeneic rejection. Here, cell adhesion, blood clotting and vasomotion collide and bring micro-and macrocirculation to a standstill. All types of xenogeneic immunological mechanisms studied so far were found to have a more serious impact than those seen in allogeneic transplantation. In addition we are now only beginning to understand that so-called immunological parameters in allogeneic mechanisms act also in a true physiological manner in the xenogeneic situation. These molecular mechanisms occur behind the curtain of hyperacute, accelerated, acute or chronic xenograft rejection of which only some folds have been lifted to allow glimpses of part of the total scene. Other obstacles are likely to arise when long-term survival is achieved. These obstacles include retroviral infections, transfer of prions and severe side effects of the massive immunosuppression which will be needed. Moral, ethical and religious concerns are under debate and the species-specific production of proteins of the foreign donor species developed for clinical use suddenly appears to be a greater problem than anticipated

How the Liquid-Liquid Transition Affects Hydrophobic Hydration in Deeply Supercooled Water

We determine the phase diagram of liquid supercooled water by extensive computer simulations using the TIP5P-E model [J. Chem. Phys. {\bf 120}, 6085 (2004)]. We find that the transformation of water into a low density liquid in the supercooled range strongly enhances the solubility of hydrophobic particles. The transformation of water into a tetrahedrally structured liquid is accompanied by a minimum in the hydration entropy and enthalpy. The corresponding change in sign of the solvation heat capacity indicates a loss of one characteristic signature of hydrophobic hydration. The observed behavior is found to be qualitatively in accordance with the predictions of the information theory model of Garde et al. [Phys. Rev. Lett. {\bf 77}, 4966 (1996)].Comment: 4 pages, 4 figures, twocolumn Revtex, modified text applied changes to figure 1, 2d, 3,

Radiation from a charged particle-in-flight from a laminated medium to vacuum

The radiation from a charged particle-in-flight from a semi-infinite laminated medium to vacuum and back,- from vacuum to the laminated medium, has been investigated. Expressions for the spectral-angular distribution of radiation energy in vacuum (at large distances from the boundary of laminated medium) were obtained for both the cases with no limitations on the amplitude and variation profile of the laminated medium permittivity. The results of appropriate numerical calculations are presented and possible applications of the obtained results are discussed.Comment: 8 pages, 6 figures, contribution to Proceedings of International Symposium RREPS-2009, 07-11 September, 2009, Zvenigorod, Russi

Probing Pauli Blocking Factors in Quantum Pumps with Broken Time-Reversal Symmetry

A recently demonstrated quantum electron pump is discussed within the framework of photon-assisted tunneling. Due to lack of time-reversal symmetry, different results are obtained for the pump current depending on whether or not final-state Pauli blocking factors are used when describing the tunneling process. Whilst in both cases the current depends quadratically on the driving amplitude for moderate pumping, a marked difference is predicted for the temperature dependence. With blocking factors the pump current decreases roughly linearly with temperature until k_B T ~ \hbar\omega is reached, whereas without them it is unaffected by temperature, indicating that the entire Fermi sea participates in the electronic transport.Comment: 4 pages in RevTex4 (beta4), 6 figures; status: to appear in PR

Reducing sample variance: halo biasing, non-linearity and stochasticity

Comparing clustering of differently biased tracers of the dark matter distribution offers the opportunity to reduce the cosmic variance error in the measurement of certain cosmological parameters. We develop a formalism that includes bias non-linearities and stochasticity. Our formalism is general enough that can be used to optimise survey design and tracers selection and optimally split (or combine) tracers to minimise the error on the cosmologically interesting quantities. Our approach generalises the one presented by McDonald & Seljak (2009) of circumventing sample variance in the measurement of $f\equiv d \ln D/d\ln a$. We analyse how the bias, the noise, the non-linearity and stochasticity affect the measurements of $Df$ and explore in which signal-to-noise regime it is significantly advantageous to split a galaxy sample in two differently-biased tracers. We use N-body simulations to find realistic values for the parameters describing the bias properties of dark matter haloes of different masses and their number density. We find that, even if dark matter haloes could be used as tracers and selected in an idealised way, for realistic haloes, the sample variance limit can be reduced only by up to a factor $\sigma_{2tr}/\sigma_{1tr}\simeq 0.6$. This would still correspond to the gain from a three times larger survey volume if the two tracers were not to be split. Before any practical application one should bear in mind that these findings apply to dark matter haloes as tracers, while realistic surveys would select galaxies: the galaxy-host halo relation is likely to introduce extra stochasticity, which may reduce the gain further.Comment: 21 pages, 13 figures. Published version in MNRA

Integration of remote sensing and surface geophysics in the detection of faults

Remote sensing was included in a comprehensive investigation of the use of geophysical techniques to aid in underground mine placement. The primary objective was to detect faults and slumping, features which, due to structural weakness and excess water, cause construction difficulties and safety hazards in mine construction. Preliminary geologic reconnaissance was performed on a potential site for an underground oil shale mine in the Piceance Creek Basin of Colorado. LANDSAT data, black and white aerial photography and 3 cm radar imagery were obtained. LANDSAT data were primarily used in optical imagery and digital tape forms, both of which were analyzed and enhanced by computer techniques. The aerial photography and radar data offered supplemental information. Surface linears in the test area were located and mapped principally from LANDSAT data. A specific, relatively wide, linear pointed directly toward the test site, but did not extend into it. Density slicing, ratioing, and edge enhancement of the LANDSAT data all indicated the existence of this linear. Radar imagery marginally confirmed the linear, while aerial photography did not confirm it