Nutritional Immunomodulation as an Approach to Decreasing the Negative Effects of Stress in Poultry Production

Stress can lead to changes in the immune response resulting in both increased and decreased resistance to opportunistic bacterial pathogens. Growth-promoting antibiotics have been a major tool in modulating hostpathogen interactions and limiting clinical and subclinical bacterial infection in confined animal production. Regulatory pressures to limit antibiotic use in poultry production and recent international marketing agreements that prohibit treating poultry with antibiotics have limited the disease-fighting tools available to poultry and livestock producers, particularly in Europe. There is a need to evaluate potential antibiotic alternatives to improve both production and disease resistance in high-intensity food animal production. Nutritional approaches to counteract the debilitating effects of stress and infection may provide producers with useful alternatives to antibiotics. Improving disease resistance in food animals, particularly in the absence of antibiotic treatment, is a key strategy in the effort to increase food safety. ARS research has demonstrated the efficacy of several nutritional immunomodulators, including vitamin D3 and yeast cell wall products, to protect against bacterial infection due to stress and challenge with opportunistic pathogens. These studies also provide an animal model for testing the efficacy of nutritional strategies that may affect the response to stress and related infection in humans

Comparison of jet Mach number decay data with a correlation and jet spreading contours for a large variety of nozzles

Small-scale circular, noncircular, single- and multi-element nozzles with flow areas as large as 122 sq cm were tested with cold airflow at exit Mach numbers from 0.28 to 1.15. The effects of multi-element nozzle shape and element spacing on jet Mach number decay were studied in an effort to reduce the noise caused by jet impingement on externally blown flap (EBF) STOL aircraft. The jet Mach number decay data are well represented by empirical relations. Jet spreading and Mach number decay contours are presented for all configurations tested

Low frequency noise in a quiet, clean, general aviation turbofan engine

A quiet, clean, general aviation, turbofan engine was instrumented to measure the fluctuating pressures in the combustor, turbine exit duct, engine nozzle and the far field. Both a separate flow nozzle and an internal mixer nozzle were tested. The fluctuating pressure data are presented in overall pressure and power levels and in spectral plots. The combustor data are compared to recent theory and found to be in excellent agreement. The results indicate that microphone correction procedures for elevated mean pressures are questionable. Ordinary coherence function analysis suggests the presence of an additional low frequency noise source downstream of the turbine that is due to the turbine itself. Low frequency narrowband data and coherence function analysis are presented

Nonlinearity and pixel shifting effects in HXRG infrared detectors

We study the nonlinearity (NL) in the conversion from charge to voltage in infrared detectors (HXRG) for use in precision astronomy. We present laboratory measurements of the NL function of a H2RG detector and discuss the accuracy to which it would need to be calibrated in future space missions to perform cosmological measurements through the weak gravitational lensing technique. In addition, we present an analysis of archival data from the infrared H1RG detector of the Wide Field Camera 3 in the Hubble Space Telescope that provides evidence consistent with the existence of a sensor effect analogous to the brighter-fatter effect found in Charge-Coupled Devices. We propose a model in which this effect could be understood as shifts in the effective pixel boundaries, and discuss prospects of laboratory measurements to fully characterize this effect.Comment: Accepted for publication in the Journal of Instrumentation (JINST). Part of "Precision Astronomy with Fully Depleted CCDs" (Dec 1-2, 2016), Brookhaven National Laboratory, Upton, NY, US

Peak axial-velocity decay with multi-element rectangular and triangular nozzles

The aircraft noise created by the impingement of engine exhaust jet of STOL aircraft with externally blown flaps is discussed. It was determined that the jet-flap interaction noise can be lowered by reducing the impinging velocity of the jet. The reduction must occur at a specific distance from the flap to be effective. The peak axial-velocity decay obtained with rectangular and triangular single element mixer nozzles is presented. Equations are developed for estimating the peak axial velocity decay curves for a wide range of nozzle configurations

A program to develop a high-energy density primary battery with a minimum of 200 watt hours per pound of total battery weight third quarterly report, jan. - mar. 1965

Electrochemical study of prospective electrode- electrolyte systems for high-energy primary battery with minimum of 200 watt hours per pound of total battery weigh

Critical Evaluation of Bacteriophage to Prevent and Treat Colibacillosis in Poultry

There is a continuing need to find alternatives to antibiotics in animal and human medicine. Bacteriophages are viruses that infect and kill bacteria, with no known activity to plant and animal cells. We have conducted research to critically evaluate the efficacy of bacteriophage to both prevent and treat colibacillosis in poultry. Bacteriophages lytic to an Escherichia coli pathogenic to poultry were isolated from municipal waste water treatment plants and poultry processing plants. Two bacteriophage isolates were selected to use in studies designed to determine the efficacy of these bacteriophage to prevent and treat severe colibacillosis in poultry. Colibacillosis was induced by injecting 6 X 104 cfu of E. coli into the thoracic airsac when the birds were 1 week of age. Initial studies demonstrated that mortality was significantly reduced when the challenge culture was mixed with bacteriophage prior to challenging the birds. In subsequent studies, we have shown that an aerosol spray of bacteriophage given to the birds prior to this E. coli challenge can prevent the disease, and that an intramuscular injection of bacteriophage provides an effective treatment of this disease. We have demonstrated that bacteriophage can be used to both prevent and treat colibacillosis in poultry and may provide an effective alternative to antibiotic use in animal and human medicine

A program to develop a high-energy density primary battery with a minimum of 200 watt hours per pound of total battery weight Fifth quarterly report, 1 Jul. - 30 Sep. 1965

High energy density primary battery development - electrochemical half-cell screening of anode- electrolyte combinations, cell discharge, and potential studie

Geometric factors affecting noise suppresion and thrust loss of divergent-lobe supersonic jet noise suppressor

The thrust loss and noise suppression of a divergent-lobe supersonic jet noise suppressor were experimentally determined over a range of nozzle pressure ratios of 1.5 to 4.0. These small-scale cold flow tests were made to determine the effect on thrust and noise of: suppressor length, rearward facing step height, suppressor divergence angle, and ejector shroud length and location. Noise suppression was achieved at nozzle pressure ratios of 2.5 and greater. Maximum lobe jet noise attenuation of 15 db with thrust loss differences of 1.5 percent compared to the convergent nozzle were obtained at a nozzle pressure ratio of 3.5 with an ejector shroud two nozzle diameters long. Without the ejector the attenuation was 13 db with thrust loss differences of 11 percent. Short suppressors approximately one primary nozzle throat diameter long performed as well as longer suppressors. Rearward facing step height had a significant effect on noise suppression. Ejector shrouds two nozzle diameters in length are feasible