Creating innovation in lymphoedema nursing through collaboration

Against a background of fiscal and regulatory pressure to rationalize and justify health-care interventions, there is an underlying political message that greater cooperation and collaboration would improve health-care for all. This article uses the specialism of lymphoedema to illustrate the developments and improvements in care which can be achieved by harnessing the knowledge and skills of the multi-disciplinary team, and those people with vision, who are prepared to innovate to improve patient care. The article argues that it is the experienced specialist who advances care both by innovation and by working to achieve consensus, which can then guide the less experienced generalist. Using specific examples of published research drawn from other specialities - leg ulcer management, varicose vein treatment and dermatology - the article shows how this supports the practice of lymphoedema practitioners

Migrant workers in the East Midlands labour market 2010

This report is an update of previous intelligence (Migrant Workers in the East Midlands Labour Market 2007) on the profile and economic impact of migrant labour in the East Midlands economy

New Cosmological Structures on Medium Angular Scales Detected with the Tenerife Experiments

We present observations at 10 and 15 GHz taken with the Tenerife experiments in a band of the sky at Dec.=+35 degrees. These experiments are sensitive to multipoles in the range l=10-30. The sensitivity per beam is 56 and 20 microK for the 10 and the 15 GHz data, respectively. After subtraction of the prediction of known radio-sources, the analysis of the data at 15 GHz at high Galactic latitude shows the presence of a signal with amplitude Delta Trms ~ 32 microK. In the case of a Harrison-Zeldovich spectrum for the primordial fluctuations, a likelihood analysis shows that this signal corresponds to a quadrupole amplitude Q_rms-ps=20.1+7.1-5.4 microK, in agreement with our previous results at Dec.+=40 degrees and with the results of the COBE DMR. There is clear evidence for the presence of individual features in the RA range 190 degrees to 250 degrees with a peak to peak amplitude of ~110 microK. A preliminary comparison between our results and COBE DMR predictions for the Tenerife experiments clearly indicates the presence of individual features common to both. The constancy in amplitude over such a large range in frequency (10-90 GHz) is strongly indicative of an intrinsic cosmological origin for these structures.Comment: ApJ Letters accepted, 13 pages Latex (uses AASTEX) and 4 encapsulated postscript figures

The Tenerife Cosmic Microwave Background Maps: Observations and First Analysis

The results of the Tenerife Cosmic Microwave Background (CMB) experiments are presented. These observations cover 5000 and 6500 square degrees on the sky at 10 and 15 GHz respectively centred around Dec.~ +35 degrees. The experiments are sensitive to multipoles l=10-30 which corresponds to the Sachs-Wolfe plateau of the CMB power spectra. The sensitivity of the results are ~31 and \~12 microK at 10 and 15 GHz respectively in a beam-size region (5 degrees FWHM). The data at 15 GHz show clear detection of structure at high Galactic latitude; the results at 10 GHz are compatible with these, but at lower significance. A likelihood analysis of the 10 and 15 GHz data at high Galactic latitude, assuming a flat CMB band power spectra gives a signal Delta T_l=30+10-8 microK (68 % C.L.). Including the possible contaminating effect due to the diffuse Galactic component, the CMB signal is Delta T_l=30+15-11 microK. These values are highly stable against the Galactic cut chosen. Assuming a Harrison-Zeldovich spectrum for the primordial fluctuations, the above values imply an expected quadrupole Q_RMS-PS=20+10-7 microK which confirms previous results from these experiments, and which are compatible with the COBE DMR.Comment: 17 pages, 7 figures. Submitted to Ap

K2P2^2 −- A photometry pipeline for the K2 mission

With the loss of a second reaction wheel, resulting in the inability to point continuously and stably at the same field of view, the NASA Kepler satellite recently entered a new mode of observation known as the K2 mission. The data from this redesigned mission present a specific challenge; the targets systematically drift in position on a ~6 hour time scale, inducing a significant instrumental signal in the photometric time series --- this greatly impacts the ability to detect planetary signals and perform asteroseismic analysis. Here we detail our version of a reduction pipeline for K2 target pixel data, which automatically: defines masks for all targets in a given frame; extracts the target's flux- and position time series; corrects the time series based on the apparent movement on the CCD (either in 1D or 2D) combined with the correction of instrumental and/or planetary signals via the KASOC filter (Handberg & Lund 2014), thus rendering the time series ready for asteroseismic analysis; computes power spectra for all targets, and identifies potential contaminations between targets. From a test of our pipeline on a sample of targets from the K2 campaign 0, the recovery of data for multiple targets increases the amount of potential light curves by a factor ${\geq}10$. Our pipeline could be applied to the upcoming TESS (Ricker et al. 2014) and PLATO 2.0 (Rauer et al. 2013) missions.Comment: 14 pages, 20 figures, Accepted for publication in The Astrophysical Journal (Apj

Differing calcification processes in cultured vascular smooth muscle cells and osteoblasts

© 2019 Published by Elsevier Inc.Arterial medial calcification (AMC) is the deposition of calcium phosphate mineral, often as hydroxyapatite, inthe medial layer of the arteries. AMC shares some similarities to skeletal mineralisation and has been associatedwith the transdifferentiation of vascular smooth muscle cells (VSMCs) towards an osteoblast-like phenotype. Thisstudy used primary mouse VSMCs and calvarial osteoblasts to directly compare the established and widely usedin vitromodels of AMC and bone formation. Significant differences were identified between osteoblasts andcalcifying VSMCs. First, osteoblasts formed large mineralised bone nodules that were associated with widespreaddeposition of an extracellular collagenous matrix. In contrast, VSMCs formed small discrete regions of calcifi-cation that were not associated with collagen deposition and did not resemble bone. Second, calcifying VSMCsdisplayed a progressive reduction in cell viability over time (≤7-fold), with a 50% increase in apoptosis,whereas osteoblast and control VSMCs viability remained unchanged. Third, osteoblasts expressed high levels ofalkaline phosphatase (TNAP) activity and TNAP inhibition reduced bone formation by to 90%. TNAP activity incalcifying VSMCs was∼100-fold lower than that of bone-forming osteoblasts and cultures treated withβ-gly-cerophosphate, a TNAP substrate, did not calcify. Furthermore, TNAP inhibition had no effect on VSMC calci-fication. Although, VSMC calcification was associated with increased mRNA expression of osteoblast-relatedgenes (e.g. Runx2, osterix, osteocalcin, osteopontin), the relative expression of these genes was up to 40-foldlower in calcifying VSMCs versus bone-forming osteoblasts. In summary, calcifying VSMCsin vitrodisplay somelimited osteoblast-like characteristics but also differ in several key respects: 1) their inability to form collagen-containing bone; 2) their lack of reliance on TNAP to promote mineral deposition; and, 3) the deleterious effectof calcification on their viability.Peer reviewedFinal Published versio

Advanced XPS characterization: XPS-based multi-technique analyses for comprehensive understanding of functional materials

X-ray photoelectron spectroscopy (XPS) has achieved maturity as an analytical technique in that it is a ubiquitous tool in the materials community, however as made apparent by recent reviews highlighting it's misuse as a means of chemical deduction, it is a practice which is greatly misunderstood even in its simplest form. Advanced XPS techniques, or a combination of XPS and a complementary surficial probe may elicit auxiliary information outside of the scope of the standard sphere of appreciation. This review aims to bring to the attention of the general materials audience a landscape of some atypical applications of lab-based XPS and combinatorial approaches of related surface analysis, such as ion scattering, ultraviolet photoelectron, electron energy loss and auger emission spectroscopies found on many lab-based instrument set-ups

The Low Surface Brightness Extent of the Fornax Cluster

We have used a large format CCD camera to survey the nearby Fornax cluster and its immediate environment for low luminosity low surface brightness galaxies. Recent observations indicate that these are the most dark matter dominated galaxies known and so they are likely to be a good tracer of the dark matter in clusters. We have identified large numbers of these galaxies consistent with a steep faint end slope of the luminosity function (alpha~ -2) down to MB ~ -12. These galaxies contribute almost the same amount to the total cluster light as the brighter galaxies and they have a spatial extent that is some four times larger. They satisfy two of the important predictions of N-body hierarchical simulations of structure formation using dark halos. The luminosity (mass ?) function is steep and the mass distribution is more extended than that defined by the brighter galaxies. We also find a large concentration of low surface brightness galaxies around the nearby galaxy NGC1291.Comment: 16 pages, 6 figure

Flux Expulsion - Field Evolution in Neutron Stars

Models for the evolution of magnetic fields of neutron stars are constructed, assuming the field is embedded in the proton superconducting core of the star. The rate of expulsion of the magnetic flux out of the core, or equivalently the velocity of outward motion of flux-carrying proton-vortices is determined from a solution of the Magnus equation of motion for these vortices. A force due to the pinning interaction between the proton-vortices and the neutron-superfluid vortices is also taken into account in addition to the other more conventional forces acting on the proton-vortices. Alternative models for the field evolution are considered based on the different possibilities discussed for the effective values of the various forces. The coupled spin and magnetic evolution of single pulsars as well as those processed in low-mass binary systems are computed, for each of the models. The predicted lifetimes of active pulsars, field strengths of the very old neutron stars, and distribution of the magnetic fields versus orbital periods in low-mass binary pulsars are used to test the adopted field decay models. Contrary to the earlier claims, the buoyancy is argued to be the dominant driving cause of the flux expulsion, for the single as well as the binary neutron stars. However, the pinning is also found to play a crucial role which is necessary to account for the observed low field binary and millisecond pulsars.Comment: 23 pages, + 7 figures, accepted for publication in Ap