115 research outputs found
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Thermal-Expansion and Fracture Toughness Properties ofParts made from Liquid Crystal Stereolithography Resins
Liquid crystal (LC) resins are a new kind ofstereolithography material that can produce
parts with structured or ordered morphologies instead ofthe amorphous morphologies that result
from standard resins. The LC molecules can be aligned before cure resulting in an anisotropic
crosslinked network when the laser induced polymerization "locks-in" the alignment. Previous
papers have explored liquid crystal orientation dynamics [1], the effects of orientation on viscoelastic and mechanical properties [2,3], and the processing ofLC resins by stereolithography [4].
This paper considers the effects ofmorphology on fracture toughness and thermal-expansion
properties. Both toughness and thermal-stability continue to be important issues for
stereolithography parts. The use ofLC resins may provide a way to significantly improve
performance in both ofthese areas, and in addition result in parts with high upper use .
temperatures.Mechanical Engineerin
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Solid Freeform Fabrication of Functional Silicon Nitride Ceramics by Laminated Object Manufacturing 1
The processing of silicon nitride (Si3N4) structural ceramics by Laminated Object
Manufacturing (LOM) using ceramic tape preforms was investigated. The key processing stages
involved green shape formation (which used the LOM process), followed by the burnout of all
organics, and final densification by pressureless sintering. Two material systems were
considered. These were a) monolithic Si3N4 and b) a preceramic polymer infiltrated Si3N4. The
raw materials for the process were tape preforms of Si3N4, which were fabricated by standard
tape casting techniques.
Mechanical property data obtained for the LOM processed Si3N4 showed high strength and
fracture toughness values. The room temperature and high temperature (1260 o
C) flexural
strengths were in the range of 700-900 MPa and 360-400 MPa, respectively. The fracture
toughness averaged from 5.5-7.5 MPa.m1/2. These strength and fracture toughness values are
comparable to those reported for conventionally prepared Si3N4 ceramics. Thus, this research
demonstrated that the LOM technique is a viable method for preparing functional Si3N4 ceramics
with good physical and mechanical properties.Mechanical Engineerin
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Effects of an Oxycodone Conjugate Vaccine on Oxycodone Self-Administration and Oxycodone-Induced Brain Gene Expression in Rats
Prescription opioid abuse is an increasing public health concern in the USA. A vaccine comprising a hapten (OXY) conjugated to the carrier protein keyhole limpet hemocyanin (OXY-KLH) has been shown to attenuate the antinociceptive effects of oxycodone. Here, the vaccine's ability to prevent acquisition of intravenous (i.v.) oxycodone self-administration was studied in rats. Effects of vaccination on oxycodone-induced changes in the expression of several genes within the mesolimbic system, which are regulated by chronic opiate use, were also examined. Vaccination with OXY-KLH reduced the proportion of rats acquiring i.v. self-administration of oxycodone under a fixed ratio (FR) 3 schedule of reinforcement compared to control rats immunized with the unconjugated KLH carrier protein. Vaccination significantly reduced the mean number of infusions at FR3, total number of infusions, and total oxycodone intake during the entire protocol. Compared to oxycodone self-administering control rats immunized with the carrier alone, rats vaccinated with the OXY-KLH immunogen showed increased levels of adenylate cyclase 5 (Adcy5) and decreased levels of early growth response protein 2 (Egr2) and the early immediate gene c-Fos in the striatum. These data suggest that vaccination with OXY-KLH can attenuate the reinforcing effects of oxycodone at a clinically-relevant exposure level. Analysis of mRNA expression identified some addiction-relevant markers that may be of interest in understanding oxycodone effects or the protection provided by vaccination
Prolonged High Fat Diet Reduces Dopamine Reuptake without Altering DAT Gene Expression
The development of diet-induced obesity (DIO) can potently alter multiple aspects of dopamine signaling, including dopamine transporter (DAT) expression and dopamine reuptake. However, the time-course of diet-induced changes in DAT expression and function and whether such changes are dependent upon the development of DIO remains unresolved. Here, we fed rats a high (HFD) or low (LFD) fat diet for 2 or 6 weeks. Following diet exposure, rats were anesthetized with urethane and striatal DAT function was assessed by electrically stimulating the dopamine cell bodies in the ventral tegmental area (VTA) and recording resultant changes in dopamine concentration in the ventral striatum using fast-scan cyclic voltammetry. We also quantified the effect of HFD on membrane associated DAT in striatal cell fractions from a separate group of rats following exposure to the same diet protocol. Notably, none of our treatment groups differed in body weight. We found a deficit in the rate of dopamine reuptake in HFD rats relative to LFD rats after 6 but not 2 weeks of diet exposure. Additionally, the increase in evoked dopamine following a pharmacological challenge of cocaine was significantly attenuated in HFD relative to LFD rats. Western blot analysis revealed that there was no effect of diet on total DAT protein. However, 6 weeks of HFD exposure significantly reduced the 50 kDa DAT isoform in a synaptosomal membrane-associated fraction, but not in a fraction associated with recycling endosomes. Our data provide further evidence for diet-induced alterations in dopamine reuptake independent of changes in DAT production and demonstrates that such changes can manifest without the development of DIO
AFM monitoring of the cut surface of a segmented polyurethane unveils a microtome-engraving induced growth process of oriented hard domains
We report on nanoscale order-disorder transitions of hard segments and their domains composed of 4,4′-methylenebis(phenyl isocyanate) - 1,4-butanediol (MDI-BD), in polycaprolactone-based (Mn = 2000 g/mol) polyurethanes (PCL-PUs), when the free surface is pre-oriented by cryo-microtoming of the material. Morphological variations of the hard domains as a function of temperature and the anisotropy of surface morphology features are captured by employing Atomic Force Microscopy (AFM) stiffness imaging by PeakForce Quantitative Nanomechanical Mapping (PF-QNM). The AFM imaging is supported by WAXS, SAXS, FTIR, and DSC measurements. The experimental results show that hard domains initially grown at the surface break apart at elevated temperatures (65 °C) and cannot be re-grown upon cooling. They require new microtoming to repeat the growth scenario. The detailed step-by-step submicron scale observations of the surfaces serve to show importance of the influence that microtoming and the time after its completion have on surface morphology, and that these shall be considered when studying polymer materials microscopically.</p
Development of a Curved Layer LOM Process for Monolithic Ceramics and Ceramic Matrix Composites
A novel rapid prototyping technology incorporating a curved layer building style was developed. The new process, based on Laminated Object Manufacturing (LOM), was designed for efficient fabrication of curved layer structures made from ceramics and fiber reinforced composites. A new LOM machine was created, referred to as Curved Layer LOM. This new machine uses ceramic tapes and fiber prepregs as feedstocks and fabricates curved structures on a curved-layer by curved-layer basis. The output of the process is a three dimensional green ceramic that is capable of being processed to a seamless, fully dense ceramic using traditional techniques. A detailed description is made of the necessary software and hardware for this new process. Also reviewed is the development of ceramic preforms and accompanying process technology for net shape ceramic fabrication. Monolithic ceramic (SiC) and ceramic matrix composite (SiC/SiC) articles were fabricated using both the flat layer and curved layer LOM processes. For making curved layer objects, the curved process afforded the advantages of eliminated stair step effect, increased build speed, reduced waste, reduced need for decubing, and maintenance of continuous fibers in the direction of curvature
The effects of Δ9-tetrahydrocannabinol on the dopamine system
Δ(9)-tetrahydrocannabinol (THC), the main psychoactive ingredient in cannabis, is a pressing concern to global mental health. Patterns of use are changing drastically due to legalisation, availability of synthetic analogues (‘spice’), cannavaping and aggrandizements in the purported therapeutic effects of cannabis. Many of THC’s reinforcing effects are mediated by the dopamine system. Due to complex cannabinoid-dopamine interactions there is conflicting evidence from human and animal research fields. Acute THC causes increased dopamine release and neuron activity, whilst long-term use is associated with blunting of the dopamine system. Future research must examine the long-term and developmental dopaminergic effects of the drug
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Novel Liquid Crystal Resins for Stereolithography: Mechanical and Physical Properties
This paper considers photocurable liquid crystal (LC) monomers which are a new class of
stereolithography resins. These resins form polymers with high upper-use temperatures. The rodlike
molecules can be aligned by an external force. When cured in an aligned state, the aligned
structure is "locked in" resulting in materials with anisotropic physical and mechanical
properties. FTIR spectroscopy, thermo-mechanical analysis (TMA), dynamic mechanical analysis
(DMA), and large strain mechanical tests were applied to liquid crystal photo-polymers, both in
the green state and after postcure. These measurements showed that the photo-polymerization
reaction locked in the molecular order. Elastic modulus in the glassy state, revealed
approximately a factor of two difference between the directions parallel and perpendicular to the
alignment. Thermal expansion measurements showed an anisotropic linear expansion that was
very small, and sometimes negative in the alignment direction. Finally, these resins demonstrated
high glass transition temperatures which could be advanced to as high as 150°C by postcuring.Mechanical Engineerin
Mechanical mapping and morphology across the length scales unveil structure-property relationships in polycaprolactone based polyurethanes
Segmented polyurethane elastomers for biomedical applications were synthesized and studied at macroscopic (by mechanical testing) and meso/nanoscopic length scales (by atomic force microscopy, AFM). The polyurethanes are composed of 4,4'-methylenebis(phenyl isocyanate), 1,4-butanediol and an ε-polycaprolactone diol. The stoichiometric ratio of the isocyanate and hydroxyl groups is constant, but the polymer diol to total diol—varies from 0 to 100 %. We show the representative features of the morphology from phase separation to mixed phases, how this is related to the mechanical properties in the bulk and locally, at exposed free surfaces and at the nanoscale. We propose a morphological model considering the molecular structure, the length of hard segments, and the dimensions of both the soft and the hard phases, respectively. Understanding such structure–property relations is pivotal to establishing designer materials and controlling the performance of the final product to achieve optimal properties in polyurethane based medical devices
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