Opioid receptors: Pinning down the opiate targets

AbstractRecent studies of knockout mice conclusively show that the mu opioid receptor mediates the analgesic effects of morphine; they further suggest that the mu opioid receptor also has a role in mediating the effects of other opioid agonists, and provide insights into the non-analgesic effects of mu opioids

Historic Notes and Documents: Life in Miami and the Keys: Two Reports and Map from the Monaco-Alana Mission, 1743

In 1743, some forty-five years after the Franciscans abandoned their disastrous mission to the Calusa, Jesuit Fathers Joseph Maria Monaco and Francisco Xavier Alaiia proposed Christianizing the Indians of the South Florida Keys.1 The natives had previously indicated that they wanted instruction, but when the priests arrived, the Indians rejected educational efforts and asked instead for supplies and whiskey. Despite the less than warm reception given the two priests, a fort was built for their protection. Alana returned to Havana to report on the expedition, leaving Monaco behind with twelve soldiers. The Governor of Cuba ordered their immediate return, however, and the stone, wood, and earthen fort was leveled to the ground so that the English could not appropriate it. In February of 1744, the Council of the Indies approved the leveling of the stockades arguing that a fort and mission would be too exposed and too expensive. Consequently, there appears to have been no more missions sent to these South Florida Indians.

Subgroups of the Torelli group

Let Mod(Sg) be the mapping class group of an orientable surface of genus g, Sg. The action of Mod(Sg) on the homology of Sg induces the well-known symplectic representation: Mod(Sg) ---\u3e Sp(2g, Z). The kernel of this representation is called the Torelli group, I(Sg). We will study two subgroups of I(Sg). First we will look at the subgroup generated by all SIP-maps, SIP(Sg). We will show SIP(Sg) is not I(Sg) and is in fact an infinite index subgroup of I(Sg). We will also classify which SIP-maps are in the kernel of the Johnson homomorphism and Birman-Craggs-Johnson homomorphism. Then we will look at the symmetric Torelli group, SI(Sg). More specifically, we will investigate the group generated by Dehn twists about symmetric separating curves denoted H(Sg). We will show the well-known Birman-Craggs-Johnson homomorphism is not able to distinguish among SI(Sg), H(Sg), or K(Sg), where K(Sg) is the subgroup generated by Dehn twists about separating curves. Elements of H(Sg) act naturally on the symmetric separating curve complex, CH(S). We will show that when g \u3e 4 Aut(CH(Sg)) = SMod^{+/-}(Sg) / \u3c i \u3e where SMod(Sg) is the symmetric mapping class group and i is a fixed hyperelliptic involution. Lastly we will give an algebraic characterization of Dehn twists about symmetric separating curves

Precision searches in dijets at the HL-LHC and HE-LHC

This paper explores the physics reach of the High-Luminosity Large Hadron Collider (HL-LHC) for searches of new particles decaying to two jets. We discuss inclusive searches in dijets and b-jets, as well as searches in semi-inclusive events by requiring an additional lepton that increases sensitivity to different aspects of the underlying processes. We discuss the expected exclusion limits for generic models predicting new massive particles that result in resonant structures in the dijet mass. Prospects of the Higher-Energy LHC (HE-LHC) collider are also discussed. The study is based on the Pythia8 Monte Carlo generator using representative event statistics for the HL-LHC and HE-LHC running conditions. The event samples were created using supercomputers at NERSC.Comment: 27 pages, 19 figure

Conflicting interests in the pathogen-host tug of war : fungal micronutrient scavenging versus mammalian nutritional immunity

Funding: The authors are supported by the European Research Council (STRIFE project funded on grant number ERC-2009-AdG-249793, http://erc.europa.eu). AJPB is also supported by the Wellcome Trust (grant numbers 080088, 097377, www.wellcome.ac.uk) and the UK Biotechnology and Biological Sciences Research Council (grant number BB/F00513X/1, www.bbsrc.ac.uk). The funders had no role in study design, data collection and analysis, decision to publish, or preparation of the manuscript.Peer reviewedPublisher PD

New Clox Systems for rapid and efficient gene disruption in Candida albicans

Acknowledgements: We are grateful to Janet Quinn, Lila Kastora, Joanna Potrykus, Michelle Leach, and others for sharing their experiences with the Clox cassettes. We thank Julia Kohler for her kind gift of the NAT1-flipper plasmid pJK863, Claudia Jacob for her advice with In-fusion cloning, and our colleagues in the Aberdeen Fungal Group for numerous stimulating discussions. Data Availability: The authors confirm that all data underlying the findings are fully available without restriction. The sequences of all Clox cassettes are available in GenBank: URA3-Clox (loxP-URA3-MET3p-cre-loxP): GenBank accession number KC999858. NAT1-Clox (loxP-NAT1-MET3p-cre-loxP): GenBank accession number KC999859. LAL (loxP-ARG4-loxP): GenBank accession number DQ015897. LHL (loxP-HIS1-loxP): GenBank accession number DQ015898. LUL (loxP-URA3-loxP): GenBank accession number DQ015899. Funding: This work was supported by the Wellcome Trust (www.wellcome.ac.uk): S.S., F.C.O., N.A.R.G., A.J.P.B. (080088); N.A.R.G., A.J.P.B. (097377). The authors also received support from the European Research Council [http://erc.europa.eu/]: DSC. ERB, AJPB (STRIFE Advanced Grant; C-2009-AdG-249793). The European Commission also provided funding [http://ec.europa.eu/research/fp7]: I.B., A.J.P.B. (FINSysB MC-ITN; PITN-GA-2008-214004). Also the UK Biotechnology and Biological Research Council provided support [www.bbsrc.ac.uk]: N.A.R.G., A.J.P.B. (Research Grant; BB/F00513X/1). The funders had no role in study design, data collection and analysis, decision to publish, or preparation of the manuscript.Peer reviewedPublisher PD

Keys to High Quality Lint and Seed with a Cotton Module Builder.

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