The X-ray surface brightness distribution from diffuse gas

We use simulations to predict the X-ray surface brightness distribution arising from hot, cosmologically distributed diffuse gas. The distribution is computed for two bands: 0.5-2 keV and 0.1-0.4 keV, using a cosmological-constant dominated cosmology that fits many other observations. We examine a number of numerical issues such as resolution, simulation volume and pixel size and show that the predicted mean background is sensitive to resolution such that higher resolution systematically increases the mean predicted background. Although this means that we can compute only lower bounds to the predicted level, these bounds are already quite restrictive. Since the observed extra-galactic X-ray background is mostly accounted for by compact sources, the amount of the observed background attributable to diffuse gas is tightly constrained. We show that without physical processes in addition to those included in the simulations (such as radiative cooling or non-gravitational heating), both bands exceed observational limits. In order to examine the effect of non-gravitational heating we explore a simple modeling of energy injection and show that substantial amounts of heating are required (i.e. 5 keV per particle when averaged over all baryons). Finally, we also compute the distribution of surface brightness on the sky and show that it has a well-resolved characteristic shape. This shape is substantially modified by non-gravitational heating and can be used as a probe of such energy injection.Comment: 11 pages, 11 figures, submitted to Ap

Extended treatment with MY-NEOVAX, personalized neoantigen-enhanced oncolytic viruses, for two end-stage cancer patients.

Neoantigen vaccines involving multi-peptides and poly-epitope-encoding RNA or DNA have undergone early phase clinical testing with modest reported antitumor effects [ 1]. The less-than-expected activity of these neoantigenic vaccines may correspond with the development of immune escape mechanisms. One permutation on neoantigen vaccines, which may counter or prevent these adaptive immune escape mechanisms, are 'personalized' oncolytic viruses that encode one or more tumor-specific transgenes. Herein, positive therapeutic effects for MY-NEOVAX™, personalized neoantigen-enhanced oncolytic adenoviruses, are described for two heavily pretreated end-stage patients, one with high-grade metastatic neuroendocrine carcinoma of the pancreas and the other with colorectal cancer metastatic to the brain, liver and lungs. To date, treatment benefit has exceeded 12 months without dose-limiting toxicities or related serious adverse events and with documented radiologic stabilization and improved performance status

The application of airborne imaging radars (L and X-band) to earth resources problems

For abstract, see N75-24064

Qualitative Communication Research Methods -2/E.

The second edition of Qualitative Communication Research Methodsbuids on the strengths of the first edition, taking readers through every step of the qualitative research process from the research idea to the finished report. Feature: • In depth discussion of research methods, designs, types of analysis, and writing strategies • Student exercise and helpful samples of field research texts and materials • Solutions to issues and problems of qualitative communication research • Progressive approach to qualitative research and its contribution to the knowledge of rapidly changing technological cultures • Examination of how new directions in critical and interpretive theory are influencing research practice in communicatio

The Specific Globular Cluster Frequencies of Dwarf Elliptical Galaxies from the Hubble Space Telescope

The specific globular cluster frequencies (S_N) for 24 dwarf elliptical (dE) galaxies in the Virgo and Fornax Clusters and the Leo Group imaged with the Hubble Space Telescope are presented. Combining all available data, we find that for nucleated dEs --- which are spatially distributed like giant ellipticals in galaxy clusters --- S_N(dE,N)=6.5 +- 1.2 and S_N increases with M_V, while for non-nucleated dEs --- which are distributed like late-type galaxies --- S_N(dE,noN)=3.1 +- 0.5 and there is little or no trend with M_V. The S_N values for dE galaxies are thus on average significantly higher than those for late-type galaxies, which have S_N < 1. This suggests that dE galaxies are more akin to giant Es than to late-type galaxies. If there are dormant or stripped irregulars hiding among the dE population, they are likely to be among the non-nucleated dEs. Furthermore, the similarities in the properties of the globular clusters and in the spatial distributions of dE,Ns and giant Es suggest that neither galaxy mass or galaxy metallicity is responsible for high values of S_N. Instead, most metal-poor GCs may have formed in dwarf-sized fragments that merged into larger galaxies.Comment: 12 pages (uses aaspp4.sty), 2 figures, 1 table, to appear in the Astrophysical Journa

RELIABILITY OF LOW-COST PORTABLE FORCE PLATFORMS FOR MEASURING VERTICAL STIFFNESS DURING RUNNING

Ground reaction force (GRF) can provide useful information such as vertical stiffness (Kvert) to practitioners working with runners and sprinters, but high equipment costs are hindering applied research. Low-cost portable force platforms may be a useful alternative to traditional biomechanical equipment. Moderately trained runners (n = 9) completed overground running trials at various speeds (2.15-5.78 m/s), Kvert was determined, and a linear regression was used to characterize the relationship between Kvert and running speed. The results showed moderate to high correlation (r2 = 0.54 to 0.87). At 3.9 m/s (14 km/h), the widest regression model confidence interval was 4.4%, which shows this procedure likely provides adequate reliability. Future research should continue to investigate the use of low-cost portable force platforms for measuring running GRF