741 research outputs found

    Journalism Portfolio

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    Tradicions - Abril (Sant Jordi

    Long-Term Landscape Changes in a Subalpine Spruce-Fir forest in Central Utah, USA

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    Background: In Western North America, increasing wildfire and outbreaks of native bark beetles have been mediated by warming climate conditions. Bioclimatic models forecast the loss of key high elevation species throughout the region. This study uses retrospective vegetation and fire history data to reconstruct the drivers of past disturbance and environmental change. Understanding the relationship among climate, antecedent disturbances, and the legacy effects of settlement-era logging can help identify the patterns and processes that create landscapes susceptible to bark beetle epidemics. Methods: Our analysis uses data from lake sediment cores, stand inventories, and historical records. Sediment cores were dated with radiometric techniques (14C and210Pb/137Cs) and subsampled for pollen and charcoal to maximize the temporal resolution during the historical period (1800 CE to present) and to provide environmental baseline data (last 10,500 years). Pollen data for spruce were calibrated to carbon biomass (C t/ha) using standard allometric equations and a transfer function. Charcoal samples were analyzed with statistical models to facilitate peak detection and determine fire recurrence intervals. Results: The Wasatch Plateau has been dominated by Engelmann spruce forests for the last ~10,500 years, with subalpine fir becoming more prominent since 6000 years ago. This landscape has experienced a dynamic fire regime, where burning events are more frequent and of higher magnitude during the last 3000 years. Two important disturbances have impacted Engelmann spruce in the historical period: 1) high-grade logging during the late 19th century; and (2) a high severity spruce beetle outbreak in the late 20th century that killed \u3e90 % of mature spruce (\u3e10 cm dbh). Conclusions: Our study shows that spruce-dominated forests in this region are resilient to a range of climate and disturbance regimes. Several lines of evidence suggest that 19th century logging promoted a legacy of simplified stand structure and composition such that, when climate became favorable for accelerated beetle population growth, the result was a landscape-scale spruce beetle outbreak. The lasting impacts of settlement-era landscape history from the Wasatch Plateau, UT may be relevant for other areas of western North America and Europe where sufficient host carrying capacity is important in managing for resistance and resilience to outbreaks

    Nanoliposomal Nitroglycerin Exerts Potent Anti-Inflammatory Effects.

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    Nitroglycerin (NTG) markedly enhances nitric oxide (NO) bioavailability. However, its ability to mimic the anti-inflammatory properties of NO remains unknown. Here, we examined whether NTG can suppress endothelial cell (EC) activation during inflammation and developed NTG nanoformulation to simultaneously amplify its anti-inflammatory effects and ameliorate adverse effects associated with high-dose NTG administration. Our findings reveal that NTG significantly inhibits human U937 cell adhesion to NO-deficient human microvascular ECs in vitro through an increase in endothelial NO and decrease in endothelial ICAM-1 clustering, as determined by NO analyzer, microfluorimetry, and immunofluorescence staining. Nanoliposomal NTG (NTG-NL) was formulated by encapsulating NTG within unilamellar lipid vesicles (DPhPC, POPC, Cholesterol, DHPE-Texas Red at molar ratio of 6:2:2:0.2) that were ~155 nm in diameter and readily uptaken by ECs, as determined by dynamic light scattering and quantitative fluorescence microscopy, respectively. More importantly, NTG-NL produced a 70-fold increase in NTG therapeutic efficacy when compared with free NTG while preventing excessive mitochondrial superoxide production associated with high NTG doses. Thus, these findings, which are the first to reveal the superior therapeutic effects of an NTG nanoformulation, provide the rationale for their detailed investigation for potentially superior vascular normalization therapies

    How Secure is Code Generated by ChatGPT?

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    In recent years, large language models have been responsible for great advances in the field of artificial intelligence (AI). ChatGPT in particular, an AI chatbot developed and recently released by OpenAI, has taken the field to the next level. The conversational model is able not only to process human-like text, but also to translate natural language into code. However, the safety of programs generated by ChatGPT should not be overlooked. In this paper, we perform an experiment to address this issue. Specifically, we ask ChatGPT to generate a number of program and evaluate the security of the resulting source code. We further investigate whether ChatGPT can be prodded to improve the security by appropriate prompts, and discuss the ethical aspects of using AI to generate code. Results suggest that ChatGPT is aware of potential vulnerabilities, but nonetheless often generates source code that are not robust to certain attacks

    Ion-beam mixing induced by atomic and cluster bombardment in the electronic stopping-power regime

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    Single crystals of magnesium oxide containing nanoprecipitates of sodium were bombarded with swift ions (∼GeV-Pb, U) or cluster beams (∼20 MeV-C60) to study the phase change induced by electronic processes at high stopping power (≳10 keV/nm). The sodium precipitates and the defect creation were characterized by optical absorption and transmission electron microscopy. The ion or cluster bombardment leads to an evolution of the Na precipitate concentration but the size distribution remains unchanged. The decrease in Na metallic concentration is attributed to mixing effects at the interfaces between Na clusters and MgO. In addition, optical-absorption measurements show a broadening of the absorption band associated with electron plasma oscillations in Na clusters. This effect is due to a decrease of the electron mean free path, which could be induced by defect creation in the metal. All these results show an influence of high electronic stopping power in materials known to be very resistant to irradiation with weak ionizing projectiles. The dependence of these effects on electronic stopping power and on various solid-state parameters is discussed
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