Extended treatment with MY-NEOVAX, personalized neoantigen-enhanced oncolytic viruses, for two end-stage cancer patients.

Neoantigen vaccines involving multi-peptides and poly-epitope-encoding RNA or DNA have undergone early phase clinical testing with modest reported antitumor effects [ 1]. The less-than-expected activity of these neoantigenic vaccines may correspond with the development of immune escape mechanisms. One permutation on neoantigen vaccines, which may counter or prevent these adaptive immune escape mechanisms, are 'personalized' oncolytic viruses that encode one or more tumor-specific transgenes. Herein, positive therapeutic effects for MY-NEOVAX™, personalized neoantigen-enhanced oncolytic adenoviruses, are described for two heavily pretreated end-stage patients, one with high-grade metastatic neuroendocrine carcinoma of the pancreas and the other with colorectal cancer metastatic to the brain, liver and lungs. To date, treatment benefit has exceeded 12 months without dose-limiting toxicities or related serious adverse events and with documented radiologic stabilization and improved performance status

Rice monitoring using ENVISAT-ASAR data: preliminary results of a case study in the Mekong River Delta, Vietnam

Vietnam is one of the world’s largest rice exporting countries, and the fertile Mekong River Delta at the southern tip of Vietnam accounts for more than half of the country’s rice production. Unfortunately, a large part of rice crop growing time coincides with a rainy season, resulting in a limited number of cloud-free optical remote sensing images for rice monitoring. Synthetic aperture radar (SAR) data allows for observations independent of weather conditions and solar illumination, and is potentially well suited for rice crop monitoring. The aim of the study was to apply new generation Envisat ASAR data with dual polarization (HH and VV) to rice cropping system mapping and monitoring in An Giang province, Mekong River Delta. Several sample areas were established on the ground, where selected rice parameters (e.g. rice height and biomass) are periodically being measured over a period of 12 months. A correlation analysis of rice parameters and radar imagery values is then being conducted to determine the significance and magnitude of the relationships. This paper describes a review of the previous research studies on rice monitoring using SAR data, the context of this on-going study, and some preliminary results that provide insights on how ASAR imagery could be useful for rice crop monitoring. More work is being done to develop algorithms for mapping and monitoring rice cropping systems, and to validate a rice yield prediction model for one year cycle using time-series SAR imagery

Identification of chromosomes involved in a Robertsonian translocation in cattle

Summary- The chromosomes involved in the robertsonian translocation described after classical Giemsa staining by Darre et al. (1974), were determined using G(GTG), R(RBA) and C(CBG) banding techniques. The chromosomes in question were identified as chromosomes 9 and 23. cattle- chromosome- robertsonian translocation Résumé- Les chromosomes impliqués dans une translocation robertsonienne décrite, tout d’abord, en coloration conventionnelle par Darre et al. (1974) ont été déterminés à l’aide des techniques de marquage G(GTG), R(RBA) et C(CBG). sont le 9 et le 23. boeuf- chromosome- translocation robertsonienne Les chromosomes concerné

Fabrication and mechanical testing of a new sandwich structure with carbon fiber network core

The aim is the fabrication and mechanical testing of sandwich structures including a new core material known as fiber network sandwich materials. As fabrication norms for such a material do not exist as such, so the primary goal is to reproduce successfully fiber network sandwich specimens. Enhanced vibration testing diagnoses the quality of the fabrication process. These sandwich materials possess low structural strength as proved by the static tests (compression, bending), but the vibration test results give high damping values, making the material suitable for vibro-acoustic applications where structural strength is of secondary importance e.g., internal panelling of a helicopter

Yb-Yb correlations and crystal-field effects in the Kondo insulator YbB12 and its solid solutions

We have studied the effect of Lu substitution on the spin dynamics of the Kondo insulator YbB12 to clarify the origin of the spin-gap response previously observed at low temperature in this material. Inelastic neutron spectra have been measured in Yb1-xLuxB12 compounds for four Lu concentrations x = 0, 0.25, 0.90 and 1.0. The data indicate that the disruption of coherence on the Yb sublattice primarily affects the narrow peak structure occurring near 15-20 meV in pure YbB12, whereas the spin gap and the broad magnetic signal around 38 meV remain almost unaffected. It is inferred that the latter features reflect mainly local, single-site processes, and may be reminiscent of the inelastic magnetic response reported for mixed-valence intermetallic compounds. On the other hand, the lower component at 15 meV is most likely due to dynamic short-range magnetic correlations. The crystal-field splitting in YbB12 estimated from the Er3+ transitions measured in a Yb0.9Er0.1B12 sample, has the same order of magnitude as other relevant energy scales of the system and is thus likely to play a role in the form of the magnetic spectral response.Comment: 16 pages in pdf format, 9 figures. v. 2: coauthor list updated; extra details given in section 3.2 (pp. 6-7); one reference added; fig. 5 axis label change

Damage analysis and fracture toughness evaluation in a thin woven composite laminate under static tension using infrared thermography

This work deals with the issue of damage growth in thin woven composite laminates subjected to tensile loading. The conducted tensile tests were monitored on-line with an infrared camera, and tested specimens were analysed using Scanning Electron Microscopy (SEM). Combined with SEM micrographs, observation of heat source fields enabled us to assess the damage sequence. Transverse weft cracking was confirmed to be the main damage mode and fiber breakage was the final damage leading to failure. For cracks which induce little variation of specimen stiffness, the classic “Compliance method” could not be used to compute energy release rate. Hence, we present here a new procedure based on the estimation of heat source fields to calculate the energy release rate associated with transverse weft cracking. The results are then compared to those computed with a simple 3D inverse model of the heat diffusion problem and those presented in the literature