Modeling the η Corvi debris disk from the sub-AU scale to its outermost regions

Dusty debris disks surrounding main sequence stars are thought to be analogues to thepopulations of small bodies of the Solar System (asteroids, comets/icy bodies and dust grains), however with often much higher masses and associated dust production rates. Mecanisms such as massive collisions or LHB-like events must therefore be invoked to justify their existence. This is especially striking for the nearby F2V star η Corvi that shows a very strong mid- and far-infrared excess despite an estimated age of ~1.4 Gyr (Lisse et al. 2012, Wyatt et al. 2005). We present new observations of the η Crv debris disk obtained in the far-infrared with Herschel/PACS and SPIRE and in the mid-infrared with the Keck Interferometer Nuller (Millan-Gabet et al. 2011). The Herschel/PACS images at 70, 100 and 160 μm reveal a well resolved belt of cold material at ~130 AU, as well as an unresolved component in the innermost parts of the system. This warmer counterpart is resolved in the mid-infrared as a strong null excess originating from within the ~2x4 AU field-of-view of the interferometer, which is reminiscent of the architecture of the Fomalhaut debris disk (Mennesson et al. 2012, Lebreton et al. 2013). The signature of warm silicate dust is also very clear in Spitzer/IRS high-resolution spectra (Chen et al. 2006) at intermediate wavelengths (10-35 μm). We undertake to establish a consistent model of the debris disk from the sub-AU scale to its outermost regions using the GRaTer radiative transfer code (Augereau et al. 1999a, Lebreton et al. 2013) by adjusting simultaneously the interferometric nulls, the resolved Herschel images and the spectro-photometric data against a large parameter space. Our analysis providesaccurate estimates of the fundamental parameters of the disk: its surface density profile, grain size distribution and mass, making it possible to unveil the origin of the dust and the relation between the cold (~50 K) Kuiper-like belt and the warm (~500 K) exo-zodiacal disk. We further discuss the possible existence of an additional dust population at intermediate temperatures and its nature. η Corvi will be of prime interest for future observations with the JWST. We finally make predictions of the ability of NIRCam and MIRI to image details in the disk at high contrast with both spatial and spectral resolution in order to obtain a better view of this complex planetary system

User assessment of Norditropin NordiFlex®,a new prefilled growth hormone pen:a Phase IV multicenter prospective study

Maith&eacute; Tauber,1 Delphine Jaquet,2 Monique Jesuran-Perelroizen,3 Marc Petrus,4 Anne Marie Bertrand,5 Regis Coutant6NordiFlex&reg; French Study Group1H&ocirc;pital des Enfants, Toulouse, 2Novo Nordisk, La D&eacute;fense C&eacute;dex, 3Cabinet d&rsquo;Endocrinologie P&eacute;diatrique, Toulouse, 4Centre Hospitalier de Bigorre, Tarbes, 5Centre Hospitalier Universitaire de Besan&ccedil;on, Besan&ccedil;on, 6Centre Hospitalier Universitaire Angers, Angers, FranceBackground/aim: In growth disorders, ensuring long-term growth hormone therapy (GHT) remains a challenge that might compromise the clinical outcome. Consequently, strategies aiming at alleviating the burden of daily injection might improve the treatment benefit. The study reported here was performed to assess the ease of use of Norditropin NordiFlex&reg; (Novo Nordisk, Princeton, NJ, USA) compared with that of the devices previously used in children treated with GHT with recombinant somatropin.Methods: This Phase IV prospective, multicenter, open-label study was conducted in France. All patients received Norditropin NordiFlex for 6 weeks. Oral questionnaires were administered by the physician to the patients and/or the parents at inclusion and at the final visit.Results: This study included 103 patients aged between 6 and 17 years. The patients assessed Norditropin NordiFlex as significantly easier to use than their previous device (median value = 7.5, P < 0.001). Almost three-quarters of patients (64.4%) preferred Norditropin NordiFlex to their previous device. Among physicians and nurses, 73% assessed Norditropin NordiFlex training as "very easy" and 26% as "easy." Norditropin NordiFlex improved patient autonomy, with 41% of patients able to self-inject the treatment.Conclusion: This study has shown that Norditropin NordiFlex is reliable, safe, and easy to use and most study patients preferred it to their previous device. These characteristics may improve the adherence to GHT.Keywords: growth hormone therapy, adherence, injection devices, preference, ease of us

PROGRESS OF CONSTRUCTION AND INSTALLATION OF THE SPIRAL2 ACCELERATOR

Officially approved in May 2005, the SPIRAL2 project is under construction at GANIL, with the active participation of French laboratories (CEA, CNRS) and international partners. This new facility is composed of a linear accelerator producing deuteron, proton and heavy ion beams in a wide range of energies and intensities, with two dedicated experimental areas in the fields of Neutron for Science (NFS) and very heavy and super heavy element production (S3). In a second step, the facility will also produce rare elements serving a low energy RIB experimental hall, or post-accelerated by means of the existing cyclotron CIME. This paper presents the performances of the main accelerator components, its construction status and the installation process into the SPIRAL2 building