Evaluating space and time oscillations of plasma radiant intensity by studying beam radial temperature

© Published under licence by IOP Publishing Ltd.Effects of space and time pulsations of non-stationary plasma on radiant intensity and the radial temperature of plasma are studied. The case, when plasma simultaneously non-stationary both in time and in space is examined. The influence of these perturbations on accuracy of definition of plasma optical features is shown

Quantum real-space transfer in a heterostructure overgrown on the cleaved edge of a superlattice

A dispersion relation for an electron in a two-layer (and also multilayer) quantum well (QW) is formed as a result of a certain combination of initial dispersion relations for each of the forming layers. Such a combination can be used to engineer new dispersion relations with desirable properties. The same relates to a two-dimensional electron gas (2DEG) induced in a multilayer medium. In this study, we consider first such a 2DEG in a specific two-layer structure where a superlattice (SL) plays the role of the second half-infinite layer, and electrons with large wave numbers along the SL vector spread from the first ordinary QW layer to this SL. As a result of such a quantum (dynamic) real-space transfer, electrons become heavier, and the dispersion relation achieves an additional negative effective mass (NEM) section. Such NEM dispersion relations were studied for several different material systems, including the two most interesting three-material systems: (1) an isomorphic Al0.15Ga0.85As//GaAs/Al0.5Ga0.5AsAl0.15Ga0.85As//GaAs/Al0.5Ga0.5As structure and (2) a strained In0.53Ga0.47As//InxGa1−xAs/InyAl1−yIn0.53Ga0.47As//InxGa1−xAs/InyAl1−y As structure (x>0.53,(x>0.53, y<0.52)y<0.52) with a strain-balanced InxGa1−xAs/InyAl1−yAsInxGa1−xAs/InyAl1−yAs SL. Most of the results were verified using a simplified 1D model, but some of them were verified by more complicated 2D-model calculations. © 2003 American Institute of Physics.Peer Reviewedhttp://deepblue.lib.umich.edu/bitstream/2027.42/70061/2/JAPIAU-93-1-330-1.pd

Influence of a dielectric medium on the phase state of carbon dioxide

The phase state of carbon dioxide gas dissolved in liquid n-heptane is determined by experimental investigations of the temperature dependences (180 < T < 250°K) of the spin-lattice relaxation time of protons, the coefficient of translational self-diffusion of n-heptane molecules and the nuclear magnetic resonance (NMR) linewidth of carbon13C. © 1987 Plenum Publishing Corporation

Treatment of the amyotrophic lateral sclerosis using of genetically modified umbilical cord blood mononuclear cells in the preclinical studies

Development of the fundamental and clinical «regenerative medicine» is based on the progress of gene, stem cell and gene-cell biotechnologies. However, the reliable preclinical investigations on animal models and more over clinical trials stay far away from the available nowadays gene and cell constructions. Neuroscience is one of the fast growing fields of knowledge in biology and medicine. Pioneer experiments in neuroscience promises breakthrough in the innovative methods for treatment of neurodegenerative diseases in near future. This review addresses strategies for gene-cell therapy of neurodegenerative diseases by the example of amyotrophic lateral sclerosis. Precisely gene modification of mononuclear fraction of umbilical cord blood cells (UCBC) by dual cassette plasmid vectors is observed. Based on our own results of transplantation of genetically modified UCBC overexpressing recombinant neural cell adhesion molecule L1, vascular endothelial growth factor, fibroblast growth factor 2, and glial derived neurotrophic factor in different combinations we provide the experimental data for usefulness of transplantation of gene modified UCBC for treating neurodegenerative diseases. In the review we discuss the efficacy of gene modification of UCBC not only for secretion of recombinant proteins, but in increasing of transplanted cells survivability, their migration possibilities and capability to differentiate in endothelial, microglial and macroglial cell types

New NIR-emissive tetranuclear Er(III) complexes with 4-hydroxo-2,1,3-benzothiadiazolate and dibenzoylmethanate ligands: synthesis and characterization

New tetranuclear heteroleptic complexes [Er4(dbm)6(O-btd)4(OH)2] (1) and [Er4(dbm)4(O-btd)6(OH)2] (2) (O-btd = 4-hydroxo-2,1,3-benzothiadiazolate and dbm = dibenzoylmethanide) and their solvates with toluene, THF and CH2Cl2 were prepared using two synthetic approaches. The structures of the products were confirmed by single-crystal X-ray diffraction. Magnetic properties of 1 and 2 are in good agreement with X-ray data. The effective magnetic moment (μeff) values at 300 K for 1 and 2 corresponds to a system of 4 non-interacting Er(III) ions in the ground state 4J15/2 with g = 6/5. At ambient temperature and upon excitation with λexc = 450 nm, complexes 1 and 2 exhibit luminescence at ∼1530 nm, i.e. in the near infra-red (NIR) region. The luminescence intensity grows with increasing the number of the (O-btd)−ligands in the complexes. This observation suggests (O-btd)− as a new efficient antenna ligand for the lanthanide-based NIR luminescence

Human umbilical cord blood mononuclear cells transfected with dual cassette plasmids (VEGF + neurotrophic factor) for the treatment of amyotrophic lateral sclerosis

To increase the viability of neural cells in neurodegenerative diseases, after neurotraumas and ischemic strokes the most important neurotrophic and neuroprotective factors, which can be used as therapeutic agents were identified in long-term studies in vitro and in vivo. These include brain-derived neurotrophic factor (BDNF), glial-derived neurotrophic factor (GDNF), insulin-like growth factor (IGF) and vascular endothelial growth factor (VEGF). One of the promising ways of the delivery of supporting neuron survival factors is considered to be transplantation of genetically modified cells overexpressing recombinant therapeutic genes. This article describes generation of cellular delivery vectors of therapeutic genes - human umbilical cord blood mononuclear cells genetically modified by dual cassette plasmids, expressing two therapeutic genes. Efficiency of transgene expression was confirmed in vitro using RT-PCR. Analysis of survival, migration, and phenotype of genetically modified cells was performed 2 weeks after transplantation into transgenic mice with amyotrophic lateral sclerosis phenotype

Micellization of alkylated 1.4-diazabicyclo[2.2.2]octane by nuclear magnetic resonance technique using pulsed gradient of static magnetic field

A phenomenon of micellization of 4-aza-1-tetradecyl-1-azoniabicyclo[2.2.2] octane bromide (AB-14) in aqueous solution has been studied by the methods of nuclear magnetic resonance using magnetic field pulse gradient and fluorimetry. The critical micelle concentration is determined; concentration dependences of percentage of free AB-14 molecules and those associated with micelles as well as radii of micelles and numbers of their aggregation are established. Effect of external and internal translational diffusion of molecules on lifetime of AB-14 molecules in micelles is investigated. © 2012 Elsevier B.V

Ультраструктура печени при действии малых доз фтора

In experiment on laboratory rats Wistars by a method of appearing through electronic microscopy of a liver it is established, that at action of small doses of fluorine (0,5 mg/kg of a fluorine-ions within 1 month) hepatocitys are exposed destructions by damp lyses, and endoteliocitys — apoptosis. A special kind destructions is migration mytochondris in kernels hepatocitys with the subsequent formation megaautohpagosomes and them lyses. In basalition to a membrane develops fibrosis and appear pathological message between space Disse and a gleam of sinusoidal capillaries. The conclusion that small doses of fluorine close to used at osteoporosis correction, cause destructive changes in a liver that does necessary to carry out the actions directed on inactivation of fluorine becomes.В эксперименте на лабораторных крысах линии Вистар методом просвечивающей электронной микроскопии печени установлено, что при действии малых доз фтора (0,5 мг фтор-ионов на 1 кг массы тела в течение 1 мес) гепатоциты подвергаются деструкции путем влажного лизиса, а эндотелиоциты — апоптозу. Особым видом деструкции является миграция митохондрий в ядра гепатоцитов с последующим образованием мегааутофагосом и их лизисом. В базальной мембране развивается фиброз и формируются патологические соустья между пространством Диссе и просветом синусоидальных капилляров. Делается вывод о том, что малые дозы фтора, близкие к используемым при коррекции остеопороза, вызывают деструктивные изменения в печени, что делает необходимым проводить мероприятия, направленные на инактивацию фтора