Electronic transport in a series of multiple arbitrary tunnel junctions

Monte Carlo simulations and an analytical approach within the framework of a semiclassical model are presented which permit the determination of Coulomb blockade and single electron charging effects for multiple tunnel junctions coupled in series. The Coulomb gap in the I(V) curves can be expressed as a simple function of the capacitances in the series. Furthermore, the magnitude of the differential conductivity at current onset is calculated in terms of the model. The results are discussed with respect to the number of junctions.Comment: 3 figures, revte

A new intense neutron generator and high-resolution detector for well logging applications

Advances in both ion source and gamma-ray detector technology at LBNL are being used to develop a new high-sensitivity neutron logging instrument. Up to 37 mA of current per 10-20 {mu}s pulse, 80-95% D{sup +}, has been produced by a 2 inch diameter pulsed multicusp ion source. A D-T neutron flux of 10{sup 9}-10{sup 10} n/s is projected from this data. CdZnTe is being developed as a possible gamma-ray detector because of its potential for good energy resolution and efficiency, and ability to operate at room temperature. 3-D time-dependent Monte Carlo calculations show the utility of this system for locating contaminants, especially chlorine-containing solvents, at remediation sites

MSF: Modulated Sub-graph Finder [version 3; peer review: 1 approved, 2 approved with reservations]

High throughput techniques such as RNA-seq or microarray analysis have proven to be invaluable for the characterizing of global transcriptional gene activity changes due to external stimuli or diseases. Differential gene expression analysis (DGEA) is the first step in the course of data interpretation, typically producing lists of dozens to thousands of differentially expressed genes. To further guide the interpretation of these lists, different pathway analysis approaches have been developed. These tools typically rely on the classification of genes into sets of genes, such as pathways, based on the interactions between the genes and their function in a common biological process. Regardless of technical differences, these methods do not properly account for cross talk between different pathways and most of the methods rely on binary separation into differentially expressed gene and unaffected genes based on an arbitrarily set p-value cut-off. To overcome this limitation, we developed a novel approach to identify concertedly modulated sub-graphs in the global cell signaling network, based on the DGEA results of all genes tested. To this end, expression patterns of genes are integrated according to the topology of their interactions and allow potentially to read the flow of information and identify the effectors. The described software, named Modulated Sub-graph Finder (MSF) is freely available at https://github.com/Modulated-Subgraph-Finder/MSF

Lung volume reduction surgery combined with cardiac interventions

Objective: Postoperative course and functional outcome were evaluated in patients who underwent lung volume reduction surgery (LVRS) or in combination with valve replacement (VR), percutaneous transluminal coronary angioplasty (PTCA), placement of a stent, or coronary artery bypass grafting (CABG). Methods: Patients with severe bronchial obstruction and hyperinflation due to pulmonary emphysema were evaluated for lung volume reduction surgery. Cardiac disorders were screened by history and physical examination and assessed by coronary angiography. Nine patients were accepted for LVRS in combination with an intervention for coronary artery disease (CAD). In addition, three patients with valve disease and severe emphysema were accepted for valve replacement (two aortic-, one mitral valve) only in combination with LVRS. Functional results over the first 6 months were analysed. Results: Pulmonary function testing demonstrates a significant improvement in postoperative FEV1 in patients who underwent LVRS combined with an intervention for CAD. This was reflected in reduction of overinflation (residual volume/total lung capacity (RV/TLC)), and improvement in the 12-min walking distance and dyspnea. Median hospital stay was 15 days (10-33). One patient in the CAD group died due to pulmonary edema on day 2 postoperatively. One of the three patients who underwent valve replacement and LVRS died on day 14 postoperatively following intestinal infarction. Both survivors improved in pulmonary function, dyspnea score and exercise capacity. Complications in all 12 patients included pneumothorax (n = 2), hematothorax (n = 1) and urosepsis (n = 1). Conclusion: Functional improvement after LVRS in patients with CAD is equal to patients without CAD. Mortality in patients who underwent LVRS after PTCA or CABG was comparable to patients without CAD. LVRS enables valve replacement in selected patients with severe emphysema otherwise inoperabl

Non Equilibrium Electronic Distribution in Single Electron Devices

The electronic distribution in devices with sufficiently small diemnsions may not be in thermal equilibrium with their surroundings. Systems where the occupancies of electronic states are solely determined by tunneling processes are analyzed. It is shown that the effective temperature of the device may be higher, or lower, than that of its environment, depending on the applied voltage and the energy dependence of the tunneling rates. The I-V characteristics become asymmetric. Comparison with recent experiments is made

Charge Solitons in 1-D Arrays of Serially Coupled Josephson Junctions

We study a 1-D array of Josephson coupled superconducting grains with kinetic inductance which dominates over the Josephson inductance. In this limit the dynamics of excess Cooper pairs in the array is described in terms of charge solitons, created by polarization of the grains. We analyze the dynamics of these topological excitations, which are dual to the fluxons in a long Josephson junction, using the continuum sine-Gordon model. We find that their classical relativistic motion leads to saturation branches in the I-V characteristic of the array. We then discuss the semi-classical quantization of the charge soliton, and show that it is consistent with the large kinetic inductance of the array. We study the dynamics of a quantum charge soliton in a ring-shaped array biased by an external flux through its center. If the dephasing length of the quantum charge soliton is larger than the circumference of the array, quantum phenomena like persistent current and coherent current oscillations are expected. As the characteristic width of the charge soliton is of the order of 100 microns, it is a macroscopic quantum object. We discuss the dephasing mechanisms which can suppress the quantum behaviour of the charge soliton.Comment: 26 pages, LaTex, 7 Postscript figure

Population Density and Seasonality Effects on Sin Nombre Virus Transmission in North American Deermice (Peromyscus maniculatus) in Outdoor Enclosures

Surveys of wildlife host-pathogen systems often document clear seasonal variation in transmission; conclusions concerning the relationship between host population density and transmission vary. In the field, effects of seasonality and population density on natural disease cycles are challenging to measure independently, but laboratory experiments may poorly reflect what happens in nature. Outdoor manipulative experiments are an alternative that controls for some variables in a relatively natural environment. Using outdoor enclosures, we tested effects of North American deermouse (Peromyscus maniculatus) population density and season on transmission dynamics of Sin Nombre hantavirus. In early summer, mid-summer, late summer, and fall 2007–2008, predetermined numbers of infected and uninfected adult wild deermice were released into enclosures and trapped weekly or bi-weekly. We documented 18 transmission events and observed significant seasonal effects on transmission, wounding frequency, and host breeding condition. Apparent differences in transmission incidence or wounding frequency between high- and low-density treatments were not statistically significant. However, high host density was associated with a lower proportion of males with scrotal testes. Seasonality may have a stronger influence on disease transmission dynamics than host population density, and density effects cannot be considered independent of seasonality

Why might a video game developer join a union?

This paper contributes to the union renewal literature by examining the union voting propensity of workers in the high-tech tertiary sector of videogame development toward different forms of unionization. We used exclusive data from a survey of videogame developers (VGD) working primarily in Anglo-Saxon countries. When looking at the factors related to voting propensity, our data indicated that the type of unionism matters and that industry/sectoral unionism is an increasingly salient model for project-based knowledge workers. This is an important policy dimension given that the legal structures and norms in Anglo-Saxon countries still tend to support decentralized enterprise-based unionism. It is also important for unions insofar as their organizing tactics remain geared toward a shop-by-shop approach or, at least, a localized geographical approach. Although additional work is required, our analyses lends support to the argument that high-commitment and high-involvement workplaces can engender a desire for collective representation and voice such as is offered through unionization. Whether this is because such workplaces step over a breaking-point line where the requirement for full alignment with employer goals becomes untenable and a source of discontent, whether this represents the existence of dual commitment where a representative agent like a union is seen as necessary to protect the work that people love, or whether there is a combination of these forces is not yet clear, but it is a critical area of future study for project-based knowledge workers

On Uniqueness of the Jump Process in Quantum Measurement Theory

We prove that, contrary to the standard quantum theory of continuous observation, in the formalism of Event Enhanced Quantum Theory the stochastic process generating individual sample histories of pairs (observed quantum system, observing classical apparatus) is unique. This result gives a rigorous basis to the previous heuristic argument of Blanchard and Jadczyk. Possible implications of this result are discussed.Comment: 31 pages, LaTeX, article; e-mail contact [email protected]